Acalypha wilkesiana flowers: Phenolic profiling, cytotoxic activity of their biosynthesized silver nanoparticles and molecular docking study for its constituents as Topoisomerase-I inhibitors

Green Silver Nanoparticles Based on the Chemical Constituents of Glinus lotoides L.: In Vitro Anticancer and Antiviral Evaluation

“…Peaks (29, 30 and 31) revealed molecular ion peaks at m/z (317, 301 and 299) and were corresponding to myricetin, quercetin and diosmetin, respectively, confirmed by the acid hydrolysis. In accordance with reported literature, peak (24) was tentatively identified as tetrahydroxy-octadecenoic acid, 52 while peak (25) was suggested to be trihydroxyoctadecenoic acid. 53 © 2020 the authors.…”

“…While, the keto group was disappeared but, the sp 2 carbon (C=C) stretch of aromatic split into two peaks and shifted into 1638 cm -1 and 1631 cm -1 . 17,24,27 These spectroscopic results described the reducing power of hydroxyl and amino groups present within the GLE and caused obvious shifts in the peaks frequencies.…”

“…It was noticed that as the increasing of G. lotoides concentration, the intensity of the SPR band increased and more Ag + ions are reduced to AgNPs. 24 TEM studies of the bio-synthesized AgNPs The prepared AgNPs shape and size were evaluated using the HRTEM technique ( Fig. 2 A-D), which reflects the image of the particle scattering for the prepared AgNPs in the solution and the capping action of the GLE in the preparation process.…”

<p>Green Synthesis of Silver Nanoparticles Using Extract of <em>Jasminum officinal</em> L. Leaves and Evaluation of Cytotoxic Activity Towards Bladder (5637) and Breast Cancer (MCF-7) Cell Lines</p>

“…The free phenylethanoids, phenolic acids and their glycosides were the major simple phenolic compounds identified in the JOLE, the identified phenyl ethanoids are salidroside hexoside (1), hydroxytyrosol hexoside (2), salidroside (3), hydroxytyrosol (4) and tyrosol (7). The identified phenolic acids are: protocatechuic acid (5), chlorogenic acid (6), phydroxy benzoic acid (8), p-coumaroyl hexoside (9), caffeoyl quinic acid (10), caftaric acid hexoside (12), dihydrosinapic acid hexoside (13), syringic acid hexoside (14), syringic acid (15), p-coumaric acid (16) and rosmarinic acid (17), as mentioned in Table 1.…”

“…12 Green synthesized silver nanoparticles differ in their biological activities according to the capping agent (plant extract) composition; silver nanoparticles (AgNPs) of Acalypha wilikesiana flowers exhibited potent cytotoxic activity against MCF-7 (breast carcinoma) and PC-3 (prostate carcinoma) cell lines, while the AgNPs of Caesalpinia gilliesii against MCF-7 showed moderate anticancer activity. 13,14 Therefore; detection of plant chemical composition tentatively by HPLC-PDA/MS/MS can identify the possible major molecular structures that play a role in green nanoparticles formation as mentioned in our previous study on other Jasminum species (Jasminum sambac). 15 In the present study, Jasminum officinale L. leaf extract (JOLE) was used for the biosynthesis of silver nanoparticles (AgNPs).…”