Acanthamoeba Keratitis Associated with Contact Lens Wear in Singapore

Por, Yong Ming; Mehta, Jodhbir S.; Chua, Jocelyn; Koh, Tse-Hsien; Khor, Wei-Boon; Fong, Allan; Lim, Jimmy; Heng, Wee Jin; Loh, Raymond; Lim, Liangzhong; Tan, Donald

doi:10.1016/j.ajo.2009.02.030

Cited by 74 publications

(60 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study from Singapore, 15 (35.7%) of the 42 patients under study required corneal grafting, with 11 undergoing therapeutic DALK, two undergoing optical PKP, one undergoing optical DALK, and one undergoing therapeutic PKP. 5 In a study from England, 40 (16.5%) of 243 patients underwent surgery. 1 Illingwort et al 14 reported that PKP was performed in nine (39.1%) out of 23 eyes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Visual outcome in Japanese patients with Acanthamoeba keratitis

Yamazoe

Yamamoto

Shimazaki-Den

et al. 2012

Eye

View full text Add to dashboard Cite

Purpose To identify prognostic factors affecting visual outcome in Acanthamoeba keratitis (AK) treated with topical chlorhexidine gluconate (CHG). Methods A total of 35 eyes in 34 patients with AK were treated with 0.02% topical CHG. Patients were divided into two groups according to the final visual outcome: Group 1, final visual acuity (VA) of 20/25 or greater (22 eyes); Group 2, less than 20/25 (13 eyes). We compared these groups and evaluated the effectiveness of topical CHG compared with outcomes in previous reports. Results Ring infiltrate was observed more often in Group 2 (4.5% vs 61.5%, OR 33.6, 95% confidence interval (CI) 3.4-333.9, Po0.01). The duration between onset and diagnosis of AK was significantly longer (24.9 days vs 48.4 days, OR 1.03, 95% CI 1.00-1.06, P ¼ 0.04) and VA at initial examination (log MAR) significantly lower (0.47 vs 1.59, OR 25.5, 95% CI 3.4-186.7, Po0.01) in Group 2 (visual outcome o20/25). Multivariate analysis revealed that only VA at initial examination was independently associated with worse visual outcome (adjusted OR 24.5, 95% CI 1.9-312.6, P ¼ 0.01). Seventeen (85.0%) of the 20 eyes diagnosed within 1 month and 24 (82.8%) of 29 eyes diagnosed within 2 months achieved a VA of 20/40 or greater. Conclusion VA at initial examination was the most predictive factors for final visual outcome in AK. Topical CHG was comparably effective to other treatments, including polyhexamethyl biguanide and propamidine isethionate.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] However, specific treatment is not established, and there are some differences in the treatment between Western and Asian countries. In Japan, anti-fungal agents, corneal scraping, chlorhexidine gluconate (CHG), or some combination of these therapies are often used to treat AK.…”

Section: Introductionmentioning

confidence: 99%

Visual outcome in Japanese patients with Acanthamoeba keratitis

Yamazoe

Yamamoto

Shimazaki-Den

et al. 2012

Eye

View full text Add to dashboard Cite

show abstract

“…60 A year after the Fusarium outbreak, there was a similar pattern of increased reporting of contact lens-related keratitis in daily wear soft contact lens use due to Acanthamoeba. [61][62][63] Independent risk factors were established in two case control studies (Table 5) and both Unlike the previous outbreak, however, o60% of cases used this product. A worldwide recall of the product was initiated in May 2007, however, since that time the disease has persisted, 66 suggesting the contribution of additional unidentified risk factors.…”

Section: Recent Trendsmentioning

confidence: 99%

Contact lens-related microbial keratitis: how have epidemiology and genetics helped us with pathogenesis and prophylaxis

Stapleton

Carnt

2011

Eye

238

189

View full text Add to dashboard Cite

show abstract

“…Advantages of DLK in infectious keratitis include less risk of intraocular entry of infectious organisms at the time of surgery and the potential for improved graft survival rates caused by less endothelial rejection and failure. In patients with severe disease involving the visual axis, earlier surgery with DLK would allow debulking of the organisms as well as preservation of autogenous endothelial cell function (Parthasarathy & Tan, 2007;Por et al, 2009;Taenaka et al, 2007). In some cases enucleation or evisceration is needed, because of inflammation, infection or secundary glaucoma (Bacon et al, 1993;Radford et al, 1998;Reinhard & Sundmacher, 2000).…”

Section: Surgical Treatmentmentioning

confidence: 99%

“…Several authors (Awwad et al, 2005;Por et al, 2009) recommend observing for at least 3 months of clinical inactivity after completion of antiamoebic therapy before attempting PK. Most recently, Kitzmann et al (Kitzmann et al, 2009) compared outcomes of 22 eyes with Acanthamoeba keratitis undergoing emergency penetrating or anterior lamellar keratoplasty and 9 eyes undergoing optical penetrating or anterior lamellar keratoplasty.…”

Section: Therapeutic/optical Keratoplastymentioning

confidence: 99%