Acanthamoeba keratitis related to orthokeratology

Lee, Jieun; Hahn, Tae Won; Oum, Boo Sup; Choi, Hee Young; Yu, Hak Sun; Lee, Jong Soo

doi:10.1007/s10792-007-9055-8

Cited by 24 publications

(13 citation statements)

References 19 publications

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“…Therefore, PHMB is considered to be the first-choice therapy for Acanthamoeba keratitis. Numerous studies proved acanthamoebicidal efficacy and good clinical outcome with prompt local treatment [39,40,[88][89][90][91][92][93][94][95][96][97][98][99][100][101][102] . On the other hand, treat-22 ment failures have been reported, particularly when presentation was late, in cases of deep stromal infection, or in rare cases of primary PHMB resistance of Acanthamoeba strains [41,42,96,103] .…”

Section: Clinical Datamentioning

confidence: 99%

Review on the Efficacy, Safety and Clinical Applications of Polihexanide, a Modern Wound Antiseptic

Hübner

Krämer²

2010

Skin Pharmacol Physiol

189

152

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Infected wounds are still one of the great challenges in medicine. In the last decade, it has become increasingly clear that antimicrobial chemotherapy is limited by the spread of antimicrobial resistance. Fortunately, new, highly effective antiseptic substances with a broad antimicrobial spectrum are available, so local treatment is expected to get increasingly more important in wound therapy. This paper reviews the antiseptic agent polihexanide (polyhexamethylene biguanide, PHMB), one of the most promising substances available today, from a clinical point of view, focusing on efficacy, safety and clinical applications.

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Section: Clinical Datamentioning

confidence: 99%

Review on the Efficacy, Safety and Clinical Applications of Polihexanide, a Modern Wound Antiseptic

Hübner

Krämer²

2010

Skin Pharmacol Physiol

189

152

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“…Two patients had been daily wearing soft contact lenses for several years and the other had worn orthokeratology contact lenses for approximately 1.5 yr. Number of young people wearing contact lenses has been increasing in Korea for correction of myopia and even for cosmetic purpose [32,33]. More attention should be paid to hygienic maintenance of contact lenses care system for prevention of AK [34].…”

Section: A M a U R It A N Ie N S Is 1 6 5 2 A P A R A D Iv Io N Ementioning

confidence: 99%

Keratitis by Acanthamoeba triangularis: Report of Cases and Characterization of Isolates

et al. 2008

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Three Acanthamoeba isolates (KA/E9, KA/E17, and KA/E23) from patients with keratitis were identified as Acanthamoeba triangularis by analysis of their molecular characteristics, a species not previously recognized to be a corneal pathogen. Epidemiologic significance of A. triangularis as a keratopathogen in Korea has been discussed. Morphologic features of Acanthamoeba cysts were examined under a microscope with differential interference contrast (DIC) optics. Mitochondrial DNA (mtDNA) of the ocular isolates KA/E9, KA/E17, and KA/E23 were digested with restriction enzymes, and the restriction patterns were compared with those of reference strains. Complete nuclear 18S and mitochondrial (mt) 16S rDNA sequences were subjected to phylogenetic analysis and species identification. mtDNA RFLP of 3 isolates showed very similar patterns to those of SH621, the type strain of A. triangularis. 16S and 18S rDNA sequence analysis confirmed 3 isolates to be A. triangularis. 18S rDNA sequence differences of the isolates were 1.3% to 1.6% and those of 16S rDNA, 0.4% to 0.9% from A. triangularis SH621. To the best of our knowledge, this is the first report, confirmed by 18S and 16S rDNA sequence analysis, of keratitis caused by A. triangularis of which the type strain was isolated from human feces. Six isolates of A. triangularis had been reported from contaminated contact lens cases in southeastern Korea.

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“…1 The cornea becomes hypoxic with lid closure during sleep, leading to the epithelium becoming swollen and hence more prone to abrasion. 2,3 Most cases of orthokeratology-associated microbial keratitis were reported to be caused by Pseudomonas aeruginosa. 4 It is becoming apparent that Acanthamoeba is one of the primary causes of keratitis after orthokeratology.…”

mentioning

confidence: 99%

“…5 Especially, the risk of Acanthamoeba keratitis is increased in patients with .1-year duration of contact lens wearing. 3 Most reported cases of Acanthamoeba keratitis after orthokeratology have involved a wearing period of .1 week. [3][4][5][6][7] The authors report a case of bilateral Acanthamoeba keratitis after wearing orthokeratology lenses for only 5 days.…”

mentioning

confidence: 99%

“…3 Most reported cases of Acanthamoeba keratitis after orthokeratology have involved a wearing period of .1 week. [3][4][5][6][7] The authors report a case of bilateral Acanthamoeba keratitis after wearing orthokeratology lenses for only 5 days. This case was diagnosed by culture by using non-nutrient agar overlaid with viable Escherichia coli and was confirmed by inverted phase contrast microscope.…”

mentioning

confidence: 99%

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