Acanthosis nigricans and diabetes mellitus in a patient with Klinefelter's syndrome: a reaction to methyltestosterone

Shuttleworth, D.; Weavind, G.P.; Graham‐Brown, R.A.C.

doi:10.1111/j.1365-2230.1987.tb01924.x

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…It is suggested that this effect is mediated through activation of receptors for other growth factors, particularly insulin-like growth factor (IGF) [72], for which insulin ]has a significant affinity [71]. Other possibilities are insulin like growth factors themselves, or androgens [73], which can produce acanthosis nigricans when given as replacement therapy [74].…”

Section: Acanthosis Nigricansmentioning

confidence: 99%

The skin in diabetes mellitus

Goodfield

Millard

1988

Diabetologia

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The skin, in common with most other organs, suffers the effects of the metabolic disturbance of diabetes meUitus. Indeed, if any two of the multiple cutaneous conditions said to be associated with diabetes are considered, 100% of patients have skin involvement [1]. We do not intend simply to list the many and varied dermatological manifestations of diabetes, but Table 1 gives a selection of the most important. Neither will we discuss in detail aspects of cutaneous infection which are common in diabetes, nor the specialised and often reviewed problem of the diabetic foot. Rather it is our intention to discuss the fundamental changes in cutaneous structure and function induced by diabetes, and the relationship of these to the pathogenesis of skin disorders. The effects of diabetes on the, skin

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Section: Acanthosis Nigricansmentioning

confidence: 99%

The skin in diabetes mellitus

Goodfield

Millard

1988

Diabetologia

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“…In literature, there was only one report indicating the relationship between methyl testosterone and acanthosis nigricans. 9 Our case is the first report showing that testosterone therapy may be related with hyperpigmentation. Drugs may rarely play a role in the etiology of drug-induced hyperpigmentation and acanthosis nigricans that should be considered in differential diagnosis.…”

Section: Discussionmentioning

confidence: 60%

A case of hyperpigmentation and acanthosis nigricans by testosterone injections

Kavala

Demir

et al. 2014

Hum Exp Toxicol

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Drug-related skin disorders may occur in many different ways. Despite pigmentary changes being less important for morbidity, these changes precipitate depressed mood and reduce self-confidence. Testosterone is a steroid hormone from the androgen group and primarily used for the treatment of hypogonadism in males. Testosterone replacement can cause skin problems like acne, hair loss, redness, pain, or infection at the injection site. The study was conducted on a 49-year-old man with adult onset idiopathic hypogonadotropic hypogonadism, which is an acquired form of isolated gonadotropin-releasing hormone deficiency. He was presented with lack of energy and decreased sexual function 10 years ago and was given an oil-based injectable blend of four esterized testosterone compounds as hormone replacement treatment in a urology polyclinic. He was referred to our polyclinic by endocrinologist because of progressive hyperpigmentation marked on his face and oral mucosa. In the present study, we report the first testosterone therapy-related facial and oral mucosal hyperpigmentation and acanthosis nigricans in the same patient.

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“…A total of 13 acanthosis nigricans-inducing drugs were identified from the systematic literature search. These drugs included nicotinic acid, [4][5][6][7][8][9][10][11][12] niacinamide, 13 insulin, [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] aripiprazole, 29 oral corticosteroids, 12,30,31 somatotrophin, 32 oral contraceptives, 33 diethylstilbestrol, [34][35][36] testosterone, 37,38 pituitary extract of β-Melanocyte stimulating hormone (β-MSH), 39 triazinate, 40 amprenavir, 41 palifermin, 42,43 and fusidic acid ointment. 44 We discuss each drug in detail below and provide a summary in Table 1 15 3 months, 15 1 year, 16 3 months, 18 4 months 22…”

Section: Study Selectionmentioning

confidence: 99%

“…37,38 A 43-year-old man with Klinefelter's syndrome treated with intramuscular methyltestosterone for testicular atrophy and low serum testosterone. 37 A 32 year-old-man with glioblastoma multiforme was treated on the same brain tumor protocol IV triazinate for 6 weeks. 40 After subsequent doses, brown pigmentation occurred in the groins which became more widespread, followed by velvety changes in the axillae and groins.…”

Section: Testosteronementioning

confidence: 99%

“…There are two reports suggesting that testosterone could be associated with development of AN. 37,38 A 43-year-old man with Klinefelter's syndrome treated with intramuscular methyltestosterone for testicular atrophy and low serum testosterone. 37 After years of treatment he presented with skin tags on his neck and axillae and pigmented axillary skin with a velvety surface.…”

Section: Testosteronementioning

confidence: 99%

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Drug‐induced acanthosis nigricans: A systematic review and new classification

Mourad

Haber

2021

Dermatologic Therapy

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Drug-induced acanthosis nigricans is an uncommon subtype of acanthosis nigricans and the data on this topic is not well understood by clinicians as it is presently limited in the literature. Previous reports of drug-induced acanthosis nigricans have simply consisted of a list of drugs possibly implicated in causing acanthosis nigricans. Several drugs listed are based on single case reports without biopsy confirmation, report of clearing on stopping the drug or reporting on whether acanthosis nigricans recurred with drug rechallenge. A comprehensive literature search was conducted using PubMed, EMBASE(Ovid), Cochrane Library, Scopus, and Web of Science electronic databases. The authors screened the initial result of the search strategy by title and abstract using the following inclusion criteria: eligible studies included those with patients who developed acanthosis nigricans secondary to a drug. This study is the first to comprehensively review the drugs that have been implicated in the development of acanthosis nigricans. A total of 38 studies were included in the systematic review, and a total of 13 acanthosis nigricans inducing drugs were identified. Nicotinic acid and insulin were the two most significant drugs that were reported to cause acanthosis nigricans. By using the results of this study, we created a revised classification system of drug-induced acanthosis nigricans which can be used as a concise framework for clinicians to refer to.

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Acanthosis nigricans and diabetes mellitus in a patient with Klinefelter's syndrome: a reaction to methyltestosterone

Abstract: Summary A patient with Klinefelter's syndrome, who developed acanthosis nigricans, diabetes mellitus and insulin resistance, is reported. The onset of these abnormalities occurred during therapy with methyltestosterone and we believe that this drug may have been responsible.

Cited by 8 publications

References 11 publications

The skin in diabetes mellitus

The skin in diabetes mellitus

A case of hyperpigmentation and acanthosis nigricans by testosterone injections

Drug‐induced acanthosis nigricans: A systematic review and new classification

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