Acanthosis nigricans, tripe palms, and sign of Leser‐Trélat in a patient with gastric adenocarcinoma: case report and literature review in China

Zhang, Na; Qian, Yue; Feng, Ai Ping

doi:10.1111/ijd.12034

Cited by 16 publications

(14 citation statements)

References 21 publications

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“…Epithelial hyperplasia with blunt mucosal projections characteristic of AN also shares significant similarities with the current case, though AN mucosal lesions tend to exhibit flat and velvety architectures rather than a nodular one [14]. In addition, though the patient's history of adenomatous cancers may lend superficial support for a diagnosis of paraneoplastic AN, it is uncommon for thyroid and breast masses to demonstrate associations with this condition, with intra-abdominal malignancies such as gastric adenocarcinoma instigating a bulk of the signature symptoms [15]. The lack of any over-pigmented surfaces within the flexor surfaces also significantly reduces the possibility of a diabetes-induced case of AN.…”

Section: Discussionsupporting

confidence: 69%

Multiple Oral Mucosal Hamartomas in a 34-Year Old Female

Elo

Sun

Laudenbach

et al. 2017

Head and Neck Pathol

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reported first noticing these lesions approximately 10 years prior. She also denied any history of oral surgery, facial trauma, and alcohol, tobacco, or recreational drug use. The patient's past medical history was significant for left and right mastectomy for bilateral ductal carcinoma and partial thyroidectomy for microcarcinoma. She received blood transfusions at multiple points during her surgical journey but her current medical regimen included only levothyroxine. Clinical FindingsIntraoral examination (Fig. 1) revealed generalized multiple white-pink round/oval papules on the patient's lips. She was noted to have a distinct 6 mm × 5 mm × 3 mm papillary lesion on the facial gingiva between teeth #25 and 26 with smaller lesions extending slightly inferiorly to the distal of teeth #27 and 28. Similar small patches of lesions were noted on her contralateral mandibular quadrant. Also noted was a 7 mm × 3 mm white lesion on her right buccal mucosa just superior to the occlusal plane on the distobuccal cusp of tooth #31. In addition, pink papillary growths were found on the palatal gingiva of teeth #1, 2, 3, 6, 7, 9, 10, and 11 (Fig. 2) along with a similar but white papillary lesion on the attached buccal gingiva of tooth #15 measuring 5 mm × 5 mm × 5 mm. Another 3 mm × 7 mm papillary cluster was noted on the lingual mandibular gingiva near teeth #21 and 22. White gingival tissue was noted on the crest of her #14 edentulous ridge site (Fig. 3). None of these lesions were removable with gauze. The tongue was otherwise normal, as was the floor of her mouth. Radiographic imaging of the maxillomandibular region was otherwise unremarkable.Abstract A case of Cowden syndrome (CS) is described in a 34-year-old African American female who reported a history of breast and thyroid malignancies. Clinical examination demonstrated multiple soft, white-pink papules across multiple mucosal surfaces of the oral cavity. Microscopy of the lesions revealed hyperkeratotic surface squamous epithelium with papillomatosis and acanthosis along with elongated rete processes. A genomic polymerase chain reaction direct sequencing using the patient's blood was positive for mutations of the PTEN gene typical of CS.

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Section: Discussionsupporting

confidence: 69%

Multiple Oral Mucosal Hamartomas in a 34-Year Old Female

Elo

Sun

Laudenbach

et al. 2017

Head and Neck Pathol

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“…5 MAN is most commonly associated with gastric adeno-carcinoma, 6 but can also be associated with many other internal malignancies like pancreatic, ovarian, endometrial, cervical, breast, testicular, lung, kidney, liver, esophageal, prostatic, pharyngeal, and adenocarcinoma of the gallbladder and lymphoma. 7 MAN has features like pruritis, hyperpigmented and hyperkeratotic plaques with velvety papillomas and more extensive distribution than benign acanthosis nigricans. 8 Tripe palms are characterised by velvety, verrucous thickening of the palms with exaggeration of skin markings.…”

Section: Discussionmentioning

confidence: 99%

Malignant Acanthosis Nigricans: An Indicator of Internal Malignancy

Rizwan

Iftikhar

Sarfraz

et al. 2019

J Coll Physicians Surg Pak

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Acanthosis nigricans is a skin disease characterised by symmetric velvety hyperpigmented, verrucous plaques of the intertriginous surfaces of the axilla, neck, inframammary, and mucocutaneous regions. Malignant acanthosis nigricans is a paraneoplastic phenomenon most commonly associated with gastric adenocarcinoma. Tripe palms, florid cutaneous papillomatosis and oral involvement along with generalised acanthosis nigricans are the features which are highly suggestive of internal malignancy. This case report describes a rare case of a patient who presented with combination of malignant acanthosis nigricans, tripe palms, florid cutaneous papillomatosis and oral involvement associated with undifferentiated malignant neoplasm of hepatic bile ducts.

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“…Tomado de: http://www.sanar.org/ cuidado-de-la-piel/acantosis-nigricans El 90% de los casos de AN maligna se asocian con neoplasias abdominales, que son gastrointestinales en el 70% al 90 % de los pacientes (13,22). El adenocarcinoma gástrico es el más frecuente, con una participación del 55%-61% (1, 13,22), y del 73% en China (23). Las otras neoplasias que también se asocian con esa alteración son las del esófago, el páncreas, el hígado y la vía biliar (13).…”

Section: Acantosis Nigricans (An)unclassified

“…Se asocia con malignidad en el 90% de los casos, y el tumor más frecuente es el adenocarcinoma gástrico (16). Puede tener inicio simultaneo (80%), preceder (12%) o aparecer después del desarrollo del tumor (8%) (23).…”

Section: Acantosis Nigricans (An)unclassified

Síndromes paraneoplásicos en tumores gastrointestinales. Revisión de tema

Paez

Regino

et al. 2017

Rev. Colomb. Gastroenterol.

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ResumenLos síndromes paraneoplásicos representan manifestaciones clínicas que producen los tumores en sitios distantes a ellos y que no están relacionadas físicamente con ellos ni con sus metástasis. Diferentes tumores gastrointestinales pueden presentar síndromes o manifestaciones sistémicas, dermatológicas, hematológi-cas, renales y neurológicas, entre otras. Aquí se ofrece una revisión de esas distintas manifestaciones. Palabras claveSíndrome paraneoplásico, gastrointestinal, tumores. AbstractParaneoplastic syndromes produce tumors at sites distant from themselves and are not physically related to those tumors or to their metastases. Various gastrointestinal tumors may present syndromes or systemic, dermatological, hematological, renal, neurological and other manifestations. This study reviews these manifestations. KeywordsParaneoplastic syndrome, gastrointestinal, tumors.Revisión de tema DOI: https://doi.org/10.22516/25007440.155 INTRODUCCIÓNLos síndromes paraneoplásicos (SPN) son un grupo heterogéneo de manifestaciones clínicas que se producen cuando un tumor provoca un daño en un órgano o sistema distante y que no están relacionadas físicamente con el tumor o sus metástasis (1). Esas alteraciones son independientes del efecto local del tumor, la invasión a otros órga-nos, los déficits nutricionales y las consecuencias derivadas del tratamiento antineoplásico (1, 2). La gran variedad de manifestaciones clínicas es secundaria a la liberación de sustancias por parte de las células neoplásicas malignas (2) que liberan hormonas, péptidos similares a hormonas, factores de crecimiento y citoquinas (1, 2, 3). Adicionalmente, también participan respuestas inmunitarias que, inicialmente, estaban dirigidas contra las nuevas sustancias o antígenos tumorales (oncoantígenos) y que, por reacción cruzada, terminan lesionando tejidos normales (3, 4) y, finalmente, acumulando complejos inmunes (5). Los diferentes SPN se dividen según el órgano o sistema al que afecten y, clásicamente, se clasifican en endocrinometabólicos, dermatológicos, hematológicos, reumatológicos y neurológicos (3). En la presente revisión, se describen los SPN producidos por tumores gastrointestinales (GI).

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Acanthosis nigricans, tripe palms, and sign of Leser‐Trélat in a patient with gastric adenocarcinoma: case report and literature review in China

Cited by 16 publications

References 21 publications

Multiple Oral Mucosal Hamartomas in a 34-Year Old Female

Multiple Oral Mucosal Hamartomas in a 34-Year Old Female

Malignant Acanthosis Nigricans: An Indicator of Internal Malignancy

Síndromes paraneoplásicos en tumores gastrointestinales. Revisión de tema

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