Accelerated graft atherosclerosis after heart transplantation.

Grant, S. C. D.; Brooks, N

doi:10.1136/hrt.69.5.469-a

Heart

1993

DOI: 10.1136/hrt.69.5.469-a

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Accelerated graft atherosclerosis after heart transplantation.

S. C. D. Grant¹,

N Brooks²

Abstract: In general, no letter should contain more than six references (also typed with double spacing).

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Cited by 4 publications

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Coronary cardiac allograft vasculopathy versus native atherosclerosis: difficulties in classification

et al. 2014

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Cardiac allograft vasculopathy is regarded as a progressive and diffuse intimal hyperplastic lesion of arteries and veins that leads to insidious vessel narrowing and to allograft ischemic disease, such as acute myocardial infarction or sudden cardiac death. The coronary lesions in transplanted hearts are considered as a particular type of arteriosclerosis with many similarities but also significant differences compared to native coronary atherosclerosis. It is particularly difficult for pathologists to systematically classify the lesions and to elucidate their origins, since over time, the allograft immune responses cause vascular pathology characterized by not only the onset of de novo fibrocellular lesions but also remodeling of already-existing native atherosclerotic lesions in the donor heart. Intraplaque hemorrhages, which result from newly formed leaky microvessels, may cause rapid increase of stenosis and generate a substrate for plaque destabilization. Comparing cardiac allograft vasculopathy from explanted hearts at autopsy with native coronary atherosclerosis from hearts removed at transplantation has revealed that ongoing intraplaque hemorrhages are also an important feature of cardiac allograft vasculopathy and may be important factors in the rapid progression of cardiac allograft vasculopathy.

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Coronary cardiac allograft vasculopathy versus native atherosclerosis: difficulties in classification

et al. 2014

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Inhibitory effect of triptolide on platelet derived growth factor-A and coronary arteriosclerosis after heart transplantation

Hachida

Lü

Zhang

et al. 1999

Transplantation Proceedings

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Recombinant adenovirus vector mediated expression of lipoprotein (a) [Lp(a)] in rabbit plasma

Ramharack¹,

Bocan²,

Imperiale

et al. 1999

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Accelerated graft atherosclerosis after heart transplantation.

Abstract: In general, no letter should contain more than six references (also typed with double spacing).

Cited by 4 publications

References 10 publications

Coronary cardiac allograft vasculopathy versus native atherosclerosis: difficulties in classification

Coronary cardiac allograft vasculopathy versus native atherosclerosis: difficulties in classification

Inhibitory effect of triptolide on platelet derived growth factor-A and coronary arteriosclerosis after heart transplantation

Recombinant adenovirus vector mediated expression of lipoprotein (a) [Lp(a)] in rabbit plasma

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