Accelerated Myelinogenesis Induced by Dietary Lipids in Rats

Confaloni, Annamaria; Avellino, C.; Campeggi, Lorenzo Malvezzi; Salvati, Serafina

doi:10.1159/000111321

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…Diet in particular has been studied in the context of developmental myelination, where polyunsaturated fatty acids (PUFAs) have been linked to increased myelin gene expression and protection against white matter injury, with PUFA administration during maternal gestation leading to accelerated myelination and early development of behavioral reflexes (Confaloni et al, 1993;Gozzo et al, 1982;Salvati et al, 1996;Salvati et al, 2002;Tian et al, 2011;Tuzun et al, 2012). PUFAs are integral components of cell membranes including myelin membranes (Yurlova et al, 2011).…”

Section: Common Effectors? the Potential For Intersecting Mechanisms mentioning

confidence: 99%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

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Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.

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Section: Common Effectors? the Potential For Intersecting Mechanisms mentioning

confidence: 99%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

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“…The type of lipid fed is also associated with morphological and biochemical changes in myelin subfractions of developing rats [Salvati et al, 1984;Srinivasaro et al, 1997], and fat intake influences the developmental increase in the mRNA levels for proteolipid protein, myelin basic protein and stearoyl CoA desaturase in the brains of neonatal mice [DeWille and Farmer, 1992]. Confaloni et al [1993] suggest that dietary lipids or their metabolites play a direct role in transducing intra-or extracellular signals, triggering cellular events that regulate the differentiation, proliferation and migration of oligodendrocytes, from which myelin is derived.…”

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confidence: 99%

Effect of Docosahexaenoic Acid Content of Maternal Diet on Auditory Brainstem Conduction Times in Rat Pups

et al. 2000

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Previous studies of dietary docosahexaenoic acid (DHA; 22:6n–3) effects on neurodevelopment have focused mainly on effects on the visual system; these studies may be confounded by effects on the retina rather than on neural pathways. Auditory brainstem conduction times (ABCTs) provide an alternate measure of central neural development. We conducted a dose-response study in which ABCTs were measured in pups whose dams were fed diets containing one of three levels of DHA (2, 4 or 6% of total fatty acids) from a single cell oil. Diets were fed during pregnancy and lactation, and pups were randomly cross-fostered on postnatal day 3 to minimize litter effects. ABCTs showed a dose-response effect, with higher levels of dietary DHA being associated with longer conduction times on postnatal day 31 (p < 0.05). Higher dietary DHA was reflected in pup cerebrums collected on postnatal days 3 and 31, and levels of arachidonic acid (AA, 20:4n–6) were inversely related to levels of DHA. This study demonstrated that the auditory brainstem response is sensitive for identifying effects of diet on neurodevelopment, and that supplementing the maternal diet with high levels of DHA may negatively impact development of the central auditory system of offspring.

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“…By 21 days, the levels of myehin proteins were present in the test group at control levels. Further results (Confaloni et al, 1993) have shown that at 7 postnatal days in rats fed microbial lipid, MBP-and PLP-positive fibers are already present in a more rostral level such as the corpus callosum. In controls, the staining fibers were detected later in brain development.…”

Section: Fig 3 Distribution Of Oligodendrocytesmentioning

confidence: 87%

Accelerated Myelinogenesis by Dietary Lipids in Rat Brain

Salvati

Sanchez

Campeggi

et al. 1996

Journal of Neurochemistry

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Our previous work showed an early development of behavioral reflexes in rats whose mothers had been fed, during pregnancy and lactation, a lipid fraction extracted from yeast grown on n‐alkanes (which contain 50% odd‐chain fatty acids) in comparison with controls fed a margarine diet. To clarify whether the observed changes might be linked to an early myelination, we have investigated mRNAs involved in myelin synthesis in the brains of offspring at 5 days of age by northern blot and in situ hybridization. Northern blot analysis showed that proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) mRNAs were higher in animals on the lipid diet compared with controls. In situ hybridization with probes specific for PLP, myelin basic protein, and MOG mRNA showed significantly higher numbers of positive cells in test animals compared with controls in all brain regions. This study shows an acceleration of myelinogenesis induced by dietary lipids. These data can give a new insight in the therapeutical approaches involved to promote repair in demyelinating diseases.

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Accelerated Myelinogenesis Induced by Dietary Lipids in Rats

Cited by 7 publications

References 13 publications

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

Effect of Docosahexaenoic Acid Content of Maternal Diet on Auditory Brainstem Conduction Times in Rat Pups

Accelerated Myelinogenesis by Dietary Lipids in Rat Brain

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