Accelerated Particle Separation in a DLD Device at Re &gt; 1 Investigated by Means of µPIV

Kottmeier, Jonathan; Wullenweber, Maike S.; Blahout, Sebastian; Hussong, Jeanette; Kampen, Ingo; Kwade, Arno; Dietzel, Andreas

doi:10.3390/mi10110768

Cited by 14 publications

(14 citation statements)

References 23 publications

(41 reference statements)

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“…The fluid flow is driven by a force that controls a predetermined constant velocity averaged over the inlet patch. In this way, Reynolds numbers 1, 10, 30 and 50 were set (calculated as in [10]). With a constant post gap of approximately G = 10 µm (with slight deviations due to edge rounding induced by the meshing), simulations were performed with post heights of H = 10 µm and H = 5 µm.…”

Section: Model Descriptionmentioning

confidence: 99%

“…Increasing the flow rate is another possibility for increasing the throughput. However, it must be noted that increasing the Reynolds number changes the flow pattern, which affects the separation [10]. There has already been some research on the use of higher flow rates in recent years [8,[11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…There has already been some research on the use of higher flow rates in recent years [8,[11][12][13][14][15]. The main findings are that increasing the Reynolds number reduces the d c , and that static vortices form behind the posts starting at a Reynolds number of 15 to 20 [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simulative Investigation of Different DLD Microsystem Designs with Increased Reynolds Numbers Using a Two-Way Coupled IBM-CFD/6-DOF Approach

et al. 2022

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Deterministic lateral displacement (DLD) microsystems are suitable for the size fractionation of particle suspensions in the size range of 0.1 to 10 µm. To be able to fractionate real particles beyond a laboratory scale, these systems have to be designed for higher throughputs. High flow resistances and increasing the clogging of the systems impose substantial challenges for industrial operation. Simulative parameter studies are suitable for improving the design of the systems; for example, the position and shape of the posts. A high-resolution, two-way coupled 6-DOF CFD-DEM approach was used to study the flow and particle behavior of different post shapes (circular and triangular) and post sizes at different Reynolds numbers. The results were compared with the classical first streamline width theory. It was shown that the streamline theory does not account for all effects responsible for the separation. Furthermore, a shift in the critical particle diameter to smaller values could be obtained when increasing the Reynolds number and also when using triangular posts with reduced post sizes compared to the post spacing. These findings can help to improve the efficiency of the systems as the post spacing could be extended, thus reducing the flow resistance and the probability of clogging.

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Section: Model Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simulative Investigation of Different DLD Microsystem Designs with Increased Reynolds Numbers Using a Two-Way Coupled IBM-CFD/6-DOF Approach

et al. 2022

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“…DLD technology was developed under specific conditions where micropillar arrays interact with laminar flow [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. This utilizes a phenomenon in which particles are transported differently for each size depending on the diffusivity of particles, fluid flow resistance, and especially laminar flow parameters [ 69 , 76 ].…”

Section: Passive Separation Group 1: Hydrodynamics-based Separationmentioning

confidence: 99%

Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles

Choe

Kim

2021

Biosensors

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Separation of micro- and nano-sized biological particles, such as cells, proteins, and nucleotides, is at the heart of most biochemical sensing/analysis, including in vitro biosensing, diagnostics, drug development, proteomics, and genomics. However, most of the conventional particle separation techniques are based on membrane filtration techniques, whose efficiency is limited by membrane characteristics, such as pore size, porosity, surface charge density, or biocompatibility, which results in a reduction in the separation efficiency of bioparticles of various sizes and types. In addition, since other conventional separation methods, such as centrifugation, chromatography, and precipitation, are difficult to perform in a continuous manner, requiring multiple preparation steps with a relatively large minimum sample volume is necessary for stable bioprocessing. Recently, microfluidic engineering enables more efficient separation in a continuous flow with rapid processing of small volumes of rare biological samples, such as DNA, proteins, viruses, exosomes, and even cells. In this paper, we present a comprehensive review of the recent advances in microfluidic separation of micro-/nano-sized bioparticles by summarizing the physical principles behind the separation system and practical examples of biomedical applications.

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“…The critical diameter (D c ) of a DLD device can be estimated for lower Reynolds number (Re) with the help of Eq. (2) which is valid for operation involving lower throughput (Re ≤ 1) [23].…”

Section: Introductionmentioning

confidence: 96%

Design and analysis of an optimized microfluidic channel for isolation of circulating tumor cells using deterministic lateral displacement technique

Bhattacharjee

Kumar

Panwala

et al. 2020

Complex Intell. Syst.

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Circulating tumor cells (CTCs) are extremely scarce cells which cut off from a primary tumor and percolate into the circulation of blood flow and are, thus, critical for precise cancer detection and treatment. Deterministic lateral displacement (DLD) which exploits asymmetric splitting of laminar flow around the implanted microposts has displayed trustworthy capabilities in separating cells of varying sizes. In this research work, a microfluidic channel consisting of three symmetrically aligned inlets and outlets and embedded circular posts has been proposed which effectively separates the CTCs from lymphocytes utilizing the concept of DLD. Using a commercial software COMSOL Multiphysics 5.4, the design of the proposed microchannel has been simulated and analyzed considering an injected blood sample containing massive CTCs and slim WBCs of radii 13.5 µm and 6 µm, respectively. The proposed model of microchannel isolates the CTCs from WBCs at a comparatively higher sample mass flow rate of 4 × 10–6 kg/s and Reynolds number of 8.9 thereby operating efficiently at higher throughput, and offers excellent linearity in terms of velocity magnitude, pressure, shear rate and Reynolds number. The computational analysis of the proposed microchannel reveals that it can isolate CTCs from WBCs with better separation ratio, offers higher throughput, reduces possibilities of clogging and maintains better uniformity of pressure distribution and other flow parameters when compared with existing microchannel designs. The maximum separation ratio for CTCs and WBCs has been obtained as 84% and 96%, respectively.

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Accelerated Particle Separation in a DLD Device at Re > 1 Investigated by Means of µPIV

Cited by 14 publications

References 23 publications

Simulative Investigation of Different DLD Microsystem Designs with Increased Reynolds Numbers Using a Two-Way Coupled IBM-CFD/6-DOF Approach

Simulative Investigation of Different DLD Microsystem Designs with Increased Reynolds Numbers Using a Two-Way Coupled IBM-CFD/6-DOF Approach

Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles

Design and analysis of an optimized microfluidic channel for isolation of circulating tumor cells using deterministic lateral displacement technique

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