Accelerated transepithelial corneal cross-linking for progressive keratoconus: a prospective study of 12 months

Aixinjueluo, Wei; Usui, Tomohiro; Miyai, Takashi; Toyono, Tetsuya; Sakisaka, Toshihiro; Yamagami, Satoru

doi:10.1136/bjophthalmol-2016-309775

Cited by 29 publications

(20 citation statements)

References 23 publications

(19 reference statements)

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“…evaluated the clinical results of accelerated transepithelial corneal cross-linking in Japanese patients with progressive KCN and reported no intraoperative or postoperative complication with significant decrease in average keratometry, Kmax, and thinnest corneal thickness and a significant improvement in BCVA. 101 Significant reduction in corneal astigmatism, Kmax and spherical equivalent with reasonable gain in Snellen's visual acuity in TE-CXL were documented by Ameen. 102 …”

Section: Transepithelial CXL Compared To Conventional Epithelium-off mentioning

confidence: 97%

Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Mohammadpour

Masoumi

Mirghorbani

et al. 2017

Journal of Current Ophthalmology

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PurposeTo review the historical background and basic principles of collagen cross-linking, to bring together the data regarding the outcomes and complications of collagen cross-linking and finally to explore the efficacy and safety of new variations of this technique.MethodsA literature review was performed using PubMed and Scopus. The following keywords were used for literature search: cross linking, crosslinking, cross-linking, keratoconus, keratectasia.ResultsIn contrast to traditional treatment modalities for keratoconus (KCN), this new technique addresses the progression of the disease. Several clinical studies have been conducted to assess the efficacy of corneal collagen cross-linking (CXL) in the last decade. The results were promising as collagen cross-linking showed significant improvement in visual acuity and keratometric values. Moreover, initial results show that it is a safe procedure with few reported complications.ConclusionCXL is an emerging treatment method in ophthalmology that offers the possibility to effectively treat progressive KCN.

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Section: Transepithelial CXL Compared To Conventional Epithelium-off mentioning

confidence: 97%

Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Mohammadpour

Masoumi

Mirghorbani

et al. 2017

Journal of Current Ophthalmology

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“…Numerous clinical studies have now been published to demonstrate the efficacy and safety of ACXL. [41][42][43][44][45][46][47][48][49] Shajari et al 50 have compared conventional and accelerated CXL and found a significant difference in the D value (a value that involves anterior and posterior corneal elevation, corneal pachymetry, and progression of corneal thinning) with more favorable results for the conventional procedure. However, other studies have demonstrated that both procedures have a comparable effect in stabilizing keratometry.…”

mentioning

confidence: 99%

Comparison of Standard Versus Accelerated Corneal Collagen Cross-Linking for Keratoconus: A Meta-Analysis

Wen

Song

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Both studies concluded that TE-ACXL is an effective method to decrease or stop the progression of keratoconus 24,25. Four more studies with TE-ACXL have been published; however, these studies used pulsed corneal irradiation instead of continuous irradiation, as in our study 32–35…”

Section: Discussionmentioning

confidence: 79%

<p>Transepithelial accelerated versus conventional corneal collagen crosslinking in patients with keratoconus: a comparative study</p>

Madeira

Vasques

Beato

et al. 2019

OPTH

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Purpose To systematically compare the efficacy of transepithelial accelerated corneal collagen crosslinking (TE-ACXL) with conventional corneal collagen crosslinking (C-CXL) in patients with progressive keratoconus. Methods Eyes of patients with progressive keratoconus who were treated with C-CXL (3 mW/cm 2 for 30 minutes) were compared with those who underwent TE-ACXL (6 mW/cm 2 for 15 minutes). Best-corrected visual acuity (BCVA), keratometry values, corneal thickness, and topometric indexes were compared before CXL, and at 2 months, 6 months, and 12 months postoperatively. Results The study enrolled 26 eyes of which 16 had TE-ACXL and 10 had C-CXL. Both groups were comparable at baseline and 12 months in terms of BCVA ( P =0.16 and P =0.57), Kmax (maximum keratometry) ( P =0.31 and P =0.73), pachymetry ( P =0.75 and P =0.37), index of surface variance (ISV) ( P =0.45 and P =0.86), index of vertical asymmetry (IVA) ( P =0.26 and P =0.61), and index of height decentration (IHD) ( P =0.27 and P =0.86, respectively). We did not observe significant differences between preoperative and 12-month postoperative readings in within-group analysis: ΔKmax (TE-ACXL, −2.13±5.41, P =0.25 vs C-CXL, 0.78±1.65, P =0.17), Δpachymetry (TE-ACXL, 4.10±14.83, P =0.41 vs C-CXL, −8.90±22.09, P =0.24), ΔISV (TE-ACXL, −8.50±21.26, P =0.24 vs C-CXL, 3.80±12.43, P =0.36), ΔIVA (TE-ACXL, −0.12±0.31, P =0.26 vs C-CXL, 0.03±0.18, P =0.61), and ΔIHD (TE-ACXL, −0.03±0.07, P =0.18 vs C-CXL, −0.01±0.03, P =0.88). Conclusion Both TE-ACXL and C-CXL were similarly effective. Further follow-up is required to determine whether these techniques are comparable in the long-term.

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Accelerated transepithelial corneal cross-linking for progressive keratoconus: a prospective study of 12 months

Abstract: UMIN000009372.

Cited by 29 publications

References 23 publications

Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Comparison of Standard Versus Accelerated Corneal Collagen Cross-Linking for Keratoconus: A Meta-Analysis

<p>Transepithelial accelerated versus conventional corneal collagen crosslinking in patients with keratoconus: a comparative study</p>

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