Accelerating innovation and commercialization through standardization of microfluidic-based medical devices

Reyes, Darwin R.; Heeren, Henne van; Guha, Sudipto; Herbertson, Luke H.; Tzannis, Alexios P; Ducrée, Jens; Bissig, Hugo; Becker, Holger

doi:10.1039/d0lc00963f

“…Regarding the bigger picture, the ability to create larger-scale integrated, fluidically functional designs with predictable reliability may enable foundry models that are commonplace in mature industries such as microelectronics and micro-electro-mechanical systems (MEMS). These efforts might be supported by existing initiatives aiming at standardisation of interfaces, manufacture and testing [85][86][87]. As valving assumes a similar role on centrifugal LoaD platforms as transistors for the emergence of integrated circuits (ICs) in (digital) electronics, the community is well equipped with the presented digital twin approach to develop large-scale integrated "bioCPUs" -Centrifugal Processing Units for implementing comprehensive bioassay panels.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Ducrée¹

2021

Preprint

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Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control mainly based on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates the provision of efficient simulation tools for virtual prototyping and characterization to greatly expedite design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, fluidic testing, bioanalytical validation and scale-up to commercial mass manufacture.

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“…Regarding the bigger picture, the ability to create larger-scale integrated, fluidically functional designs with predictable reliability may enable foundry models that are commonplace in mature industries such as microelectronics and micro-electro-mechanical systems (MEMS). These efforts might be supported by existing initiatives aiming at standardization of interfaces, manufacture and testing [120][121][122]. As valving assumes a similar role on centrifugal LoaD platforms as transistors for the emergence of integrated circuits (ICs) in (digital) electronics, the community is well equipped with the presented digital twin approach to develop large(r)-scale integrated "bioCPUs" -Centrifugal Processing Units for implementing multi-step, multi-reagent and multi-analyte bioassay panels.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Ducrée¹

2021

Preprint

Self Cite

View full text Add to dashboard Cite

Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control mainly based on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates the provision of efficient simulation tools for virtual prototyping and characterization to greatly expedite design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, fluidic testing, bioanalytical validation and scale-up to commercial mass manufacture.

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“…There are yet important issues to be resolved for biomedical applications, in particular the lack of standardization as it concerns material selection, process development, and tool design to reach the desired goal [ 180 ]. The material properties should be well correlated either with fabrication methods or biological purposes.…”

Section: Discussionmentioning

confidence: 99%

Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations

Staicu

¹

,

Jipa

²

,

Axente

³

et al. 2021

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Lab-on-a-chip (LOC) and organ-on-a-chip (OOC) devices are highly versatile platforms that enable miniaturization and advanced controlled laboratory functions (i.e., microfluidics, advanced optical or electrical recordings, high-throughput screening). The manufacturing advancements of LOCs/OOCs for biomedical applications and their current limitations are briefly discussed. Multiple studies have exploited the advantages of mimicking organs or tissues on a chip. Among these, we focused our attention on the brain-on-a-chip, blood–brain barrier (BBB)-on-a-chip, and neurovascular unit (NVU)-on-a-chip applications. Mainly, we review the latest developments of brain-on-a-chip, BBB-on-a-chip, and NVU-on-a-chip devices and their use as testing platforms for high-throughput pharmacological screening. In particular, we analyze the most important contributions of these studies in the field of neurodegenerative diseases and their relevance in translational personalized medicine.

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Accelerating innovation and commercialization through standardization of microfluidic-based medical devices

Abstract: Worldwide, the microfluidics industry has grown steadily over the last 5 years, with the market for microfluidic medical devices experiencing a compound growth rate of 22 %. The number of...

Cited by 100 publications

References 33 publications

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations

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