Mixed-effects models, also called multilevel models and hierarchical models, provide a framework for the study of clustered data when randomly selected units of study are nested within higher-order units that are also randomly selected. Hierarchical data structures occur in many domains, including psychology, sociology, business, nursing, and medicine. A classic example is education, where students are "nested" within classrooms. This general methodology addresses the dependencies of scores within random clusters by allowing coefficients defining a data model to vary across clusters. Many books are devoted to the study of these models, including Davidian and Giltinan (1995), Hox (2002), Kreft and de Leeuw (1998), Longford (1993), Raudenbush and Bryk (2002), Singer and Willett (2003), and Snijders and Bosker (1999). A mixed-effects model allows for both the study of variables at multiple levels and for interactions between variables at different levels. Estimation of effects at the different levels is simultaneous. The methodology is flexible, allowing for unbalanced data, such as unequal group sizes.Given the adaptable nature of this approach, mixedeffects models are increasingly used in areas where stratified sampling is common. This is also due in part to the widespread availability of statistical software packages for estimating these models. These include HLM Hedeker's programs for a variety of mixed-effects models (available for downloading at tigger.uic.edu/~hedeker/ mix.html).These models are also applied to repeated measures and longitudinal data in which repeated measures of the same variable are taken, for example, within a single experimental session or across some specified time period. Such data are hierarchically structured because the repeated measures are nested within individuals. Because of the flexibility of the methodology, individuals need not be assessed the same number of times or measured (in the context of time-structured data) according to the same measurement occasions (Jennrich & Schluchter, 1986). Thus, unbalanced data and unequal spacing between assessments (for time-structured data) are easily handled. This means the methodology has greater utility than classic methods, such as a repeated measures ANOVA, which requires complete, time-balanced data. In cases of timestructured data in particular, taking into account accurate measures of time may be important in many studies in which change is a primary focus (e.g., Collins & Graham, 2002).In the context of longitudinal data in particular, the models are often called latent curve models (Meredith & Tisak, 1984, 1990. In a latent curve model, an individual's response is typically studied as a function of time with the addition of time-specific error. Coefficients characterizing the response over time, such as an intercept and linear time effect when change is linear, may be individual-specific; for instance, each individual may have a unique intercept and time effect. These individual-specific effects, called random coefficients or r...