Accelerator production of the positron emitter zirconium-89

Sadeghi, Mahdi; Enferadi, Milad; Bakhtiari, Mahdi

doi:10.1016/j.anucene.2011.11.014

Cited by 39 publications

(16 citation statements)

References 49 publications

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“…The yields obtained were consistent with previous cross sections and yields for the 89 Y(p,n) 89 Zr reaction (Sadeghi et al, 2012; Taghilo et al, 2012). The yield from the Siemens Eclipse machine is lower than for other reports because the energy on yttrium is only 10.7 MeV, which is just at the energy where the cross section for this reaction is reaching its maximum.…”

Section: Discussionsupporting

confidence: 90%

“…The thick target yield in MBq/μA h from our dual foil targets agreed well with the theoretical thick target yield for the 89 Y (p, n) 89 Zr reaction using different models reported by Sadeghi et al (2012) (Fig. 3) indicating that we were not losing appreciable amounts of beam.…”

Section: Discussionsupporting

confidence: 87%

“…Nonetheless, this simple method using a target that can be built in house makes it possible to obtain 840 MBq (22 mCi) in a single 1 h irradiation. This is lower than has been reported by most other investigators that ranged from 12 to 61 MBq/μA h (Sadeghi et al, 2012). However, all of those reports started with energies greater than that reported here, although many were also thin (low MeV stopping ranges) targets.…”

Section: Discussioncontrasting

confidence: 62%

“…For a 10.7 MeV beam directly hitting natural 89 Y foils we calculated that 0.47 mm thick of yttrium foil would reduce the energy of the proton beam to 4.0 MeV, reducing the cross section from 700 to 850 mb at 10.7 MeV to < 20 mb (Zeigler and Littmark, 1980; Sadeghi et al, 2012). Stacks of 0.1 mm foils totaling 0.5 mm were tested but the foils did not transfer heat well enough to the next foil, even with compression to improve contact and the foils were vaporized through the center.…”

Section: Resultsmentioning

confidence: 99%

“…In recent years, the use of 89 Zr has increased significantly, particularly as a radiolabel for antibodies where a several-day half-life is required (Link et al, 1986; DeJesus and Nickles, 1990; Fischer et al, 2013; Holland et al, 2009; Meijs et al, 1992, 1997; Borjesson et al, 2006; Zhang et al, 2011; Bhattacharyya et al, 2013). The most common method for production of 89 Zr uses a cyclotron and the 89 Y(p,n) 89 Zr reaction (Sadeghi et al, 2012) and the cross sections for this production have been reported by many investigators including Levkovskii (1991); Wenrong et al (1992); Uddin et al (2005); Omara et al (2009); Sadeghi et al (2012); Kakavand and Taghilo (2013); and for the 89 Y(d,2 n) 89 Zr reaction by Zweit et al (1991). Despite the increasing use of this radionuclide, production has been limited to a few centers that have specialized targets for cyclotrons of ≥ 15 MeV.…”

Section: Introductionmentioning

confidence: 99%

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A simple thick target for production of 89Zr using an 11 MeV cyclotron

Link

Krohn

O’Hara

2017

Applied Radiation and Isotopes

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The growing interest but limited availability of 89Zr for PET led us to test targets for the 89Y(p,n) reaction. The goal was an easily constructed target for an 11 MeV Siemens cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90° foil tolerated 41 μA without damage and produced ~800 MBq/h, > 20 mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 62%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A simple thick target for production of 89Zr using an 11 MeV cyclotron

Link

Krohn

O’Hara

2017

Applied Radiation and Isotopes

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A Brief Review of Radiolabelling Nucleic Acid‐Based Molecules for Tracking and Monitoring

Edelmann,

Sladojevich,

Husbands

et al. 2024

Labelled Comp Radiopharmac

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The rise of nucleic acid‐based therapeutics continues apace. At the same time, the need for radiolabelled oligonucleotides for determination of spatial distribution is increasing. Complex molecular structures with mostly multiple charges and low solubility in organic solvents increase the challenge of integrating radionuclides. In preclinical research, it is important to understand the fate of new drug candidates in biodistribution studies, target binding or biotransformation studies. Depending on a specific question, the selection of a respective radiolabelling strategy is crucial. Radiometals for molecular imaging with positron emission tomography or single‐photon computed tomography generally require an attached chelating agent for stable complexation of the metal with the oligonucleotide, whereas labelling using carbon‐11/‐14 or tritium allows incorporation of the radioisotope into the native structure without altering it. Moreover, the suitability of direct radiolabelling of the oligonucleotide of interest or indirect radiolabelling, for example, by a two‐step pretargeting approach, for the study design requires consideration. This review focuses on the challenges of radiolabelling nucleic acid‐based molecules with beta‐plus, gamma and beta‐minus emitters and their use for tracking and monitoring.

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