Acceptability of CoaguChek S and CoaguChek XS generated international normalised ratios against a laboratory standard in a paediatric setting

Williams, Vaughan; Griffiths, Adrian

doi:10.1080/00313020701684797

Cited by 31 publications

(35 citation statements)

References 9 publications

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“…However, our findings are consistent with results of recent studies in adults, also showing that the newer CoaguChek XS is more precise and accurate than the older CoaguChek S monitor [21,22,23]. Our results are also consistent with the results of another recent pediatric study showing a much more satisfactory performance of the CoaguChek XS compared with the CoaguChek S [16]. However, in this study, laboratory INR measurements were performed not on venous but on capillary specimens, which may potentially influence comparisons of INR results [16].…”

Section: Discussionsupporting

confidence: 83%

“…Our results are also consistent with the results of another recent pediatric study showing a much more satisfactory performance of the CoaguChek XS compared with the CoaguChek S [16]. However, in this study, laboratory INR measurements were performed not on venous but on capillary specimens, which may potentially influence comparisons of INR results [16]. …”

Section: Discussionsupporting

confidence: 82%

“…Unfortunately, only few studies evaluating capillary INR monitoring in children have been conducted so far [10,11,12,13,14,15,16]. In particular, very few pediatric data are available on the newer PT monitor, CoaguChek XS.…”

Section: Introductionmentioning

confidence: 99%

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Self-Monitoring of Oral Anticoagulation Therapy in Children

Paioni¹,

Kroiss

Kägi³

et al. 2009

Acta Haematol

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This study aimed to investigate the accuracy of home International Normalized Ratio (INR) self-monitoring in pediatric patients on long-term oral anticoagulation therapy. Statistical and clinical agreement of INR values from capillary whole blood samples measured by 2 different portable prothrombin time monitors (CoaguChek S and XS) and venous blood samples measured by a laboratory coagulation analyzer were evaluated using the Bland-Altman analysis. Eighty-three INR comparisons (56 using the CoaguChek S and 27 using the CoaguChek XS) were obtained from 35 children aged 4 months to 18 years. Mean differences between venous and capillary INR values and their limits of agreement were –0.04 (–0.63 to 0.55) overall, 0.006 (–0.63 to 0.65) for the CoaguChek S and –0.13 (–0.57 to 0.31) for the CoaguChek XS. The Pearson correlation coefficients were 0.88 overall, 0.84 for the CoaguChek S and 0.95 for the CoaguChek XS. Expanded and narrow agreements for all patients were 97.6 and 94%, respectively. In conclusion, home INR self-monitoring is accurate for children requiring long-term oral anticoagulation therapy. Our data suggest that INR self-monitoring with the newer CoaguChek XS is more accurate than with the older CoaguChek S monitor.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 82%

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Self-Monitoring of Oral Anticoagulation Therapy in Children

Paioni¹,

Kroiss

Kägi³

et al. 2009

Acta Haematol

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“…These results are in line with previous investigations that found a good to acceptable, but somewhat inconsistent accuracy of CoaguChek XS [1,[9][10][11][12][13][14][15] in the hands of medical staff. In conclusion, the CoaguChek XS is a reliable instrument in POCT and of value in PSM of oral anticoagulation.…”

supporting

confidence: 82%

Accuracy of the point‐of‐care coagulometer CoaguChek XS in the hands of patients

Nagler

Raddatz-Müller

Schmid

et al. 2013

Journal of Thrombosis and Haemostasis

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“…The average difference between the methods remained stable up to INR 3, rising when in supratherapeutic levels. Most clinical studies for validation of the POC PT confirm this trend of increasing discrepancy between the methods [8][9][10][11][12][13]. For this reason, some authors recommend the determination of Point-of-care device in anticoagulation clinics Colella et al 173 PT by traditional methods when the result of the POC is high [8].…”

Section: Resultsmentioning

confidence: 88%

Performance of a point-of-care device in determining prothrombin time in an anticoagulation clinic

Colella

Fiusa²,

Orsi³

et al. 2012

Blood Coagulation &Amp; Fibrinolysis

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New portable devices for the measurement of the prothrombin time and the international normalized ratio (INR) from capillary blood samples have demonstrated to have good correlation with classic laboratory methods in multiple clinical settings. In this study, we evaluated the performance of the point-of-care device CoaguChek XS (CoaguChek XS; Roche Diagnostics, Basel, Switzerland), comparing the INR results with the standard laboratory method (automatic coagulometer) in an outpatient anticoagulation clinic. Results were compared by linear regression and Bland-Altman plot. Two hundred paired results were collected from 170 patients in a period of 90 days. The main indications for anticoagulation were prophylaxis of venous thromboembolic events, atrial fibrillation and prosthetic heart valves. Mean INR results obtained with the portable device and with the standard laboratory method were 2.22 ± 0.70 and 2.30 ± 0.77, respectively. The proportion of patients with supratherapeutic INRs was 13.5%. The CoaguChek XS monitor tended to underestimate the INR on average by 0.08 U. The correlation coefficient (R) between the two methods was 0.91 (P < 0.0001). The CoaguChek XS device is suitable for INR monitoring in patients in outpatient oral anticoagulation clinics.

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Acceptability of CoaguChek S and CoaguChek XS generated international normalised ratios against a laboratory standard in a paediatric setting

Cited by 31 publications

References 9 publications

Self-Monitoring of Oral Anticoagulation Therapy in Children

Self-Monitoring of Oral Anticoagulation Therapy in Children

Accuracy of the point‐of‐care coagulometer CoaguChek XS in the hands of patients

Performance of a point-of-care device in determining prothrombin time in an anticoagulation clinic

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