Acceptable Strategies for Dealing With Hereditary Breast/Ovarian Cancer Risk

Eisinger, François; Sobol, Hagay; Reynier, Claire Julian; Chabal, Françoise; Moatti, Jean‐Paul; Luquet, Christophe

doi:10.1093/jnci/89.10.731

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…Closed questions were then tested in a pilot survey carried out in Marseilles in 1995 [Eisinger et al, 1997]. The preconsultation questionnaire was designed to collect health status and sociodemographic characteristics with a view to comparing the respondents and nonrespondents to the post-consultation questionnaire and to obtain data on the attitudes towards available preventive options whether a cancer risk would be detected [Eisinger et al, 1997].…”

Section: Consultees' Questionnairesmentioning

confidence: 99%

Disclosure to the family of breast/ovarian cancer genetic test results: Patient's willingness and associated factors

et al. 2000

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Informed probands are key actors for disclosing genetic information to their relatives when a mutation has been identified in the family. The objectives were to study women's attitudes towards the family disclosure of positive breast cancer genetic testing results and to determine the predictive factors of the diffusion patterns observed. A national multi-center cross-sectional survey was carried out at five French cancer genetic clinics during a 1-year period. Self-administered questionnaires were completed after the consultation by 84.5% (398/471) of women attending breast cancer genetic clinics for the first time. Among the 383 respondents who had at least one living first-degree relative to inform, 8.6% would inform none, 33.2% would inform at least one of them, and 58.2% would inform all of them. The sibship would be the most frequently informed blood relatives, sisters in 86.9% and brothers in 79% compared with mother in 71.4%, children in 70.4%, and father in 64.9%. Women of the family would be more frequently informed than men (P < 0.05). After multivariate adjustment, age, the fact to be affected by cancer, the number of daughters, and the emotional disturbance due to cancer in a close relationship were the main determinants (P < 0.05) of the diffusion patterns observed. The first step of the relatives' attendance to genetic counseling and the proband's willingness to disclose breast cancer genetic tests results was high in this study and was clearly dependent on the women's personal and emotional characteristics.

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Section: Consultees' Questionnairesmentioning

confidence: 99%

Disclosure to the family of breast/ovarian cancer genetic test results: Patient's willingness and associated factors

et al. 2000

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“…Strategies to mitigate risk include intensive cancer screening, chemoprevention, and risk-reducing surgery (prophylactic mastectomy and/or salpingooophorectomy) (ACS, 2007;Babb et al, 2002;Eisinger et al, 1997;Foster et al, 2002). These vary in the extent to which they are effective, physically and emotionally ac ceptable to women at high genetic risk cancer, and practical at various life-course stages.…”

Section: Introductionmentioning

confidence: 99%

Disclosure of positive BRCA1/2-mutation status in young couples: The journey from uncertainty to bonding through partner support.

Hoskins

Roy

Peters

et al. 2008

Families, Systems, & Health

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BRCA1/2-positive women who learn their mutation status early in the life-course face unique challenges related to navigating the tasks of young adulthood. Using qualitative methods and grounded theory, the authors analyzed in-depth interviews with 11 women aged 26 to 35 who learned their mutation status before marriage. Their narratives illustrate the complexity of relationship formation, and highlight the potential for relationship-bonding and intimacy-building in the course of sharing mutation information. Disclosing BRCA mutation status to dating partners is often preceded by feelings of fear and anxiety, yet many participants reported that doing so has positive effects on relationships. Partners' abilities to respond with interest, empathy, and affection are associated with in creased future intimacy, consistent with generally accepted principles within the family/couple systems field. Individual cancer risk perception and familial cancer experiences may affect the disclosure experience, which can be understood via Attachment Theory. Our findings provide clinical insight, identify new areas for research, and suggest ways to assist this unique population in their adjustment to being BRCA mutation-positive.

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“…Research programs were developed mainly on hereditary breast cancers: on molecular aspects by linkage analysis or mutation search [12,[20][21][22]; genetic heterogeneity, analysis of penetrance, and genotype-phenotype correlations [23][24][25]; natural history prognosis and morphoclinical aspects [26,27]; and BRCA1 mutation screening strategies [28,29]. In addition, programs were also developed on public health and sociological aspects of cancer genetics: expectations of patients [30,31], impact of consultations [32][33][34], acceptability of genetic tests [35,36] and acceptability of strategies to deal with hereditary breast and ovarian cancer to patients [37][38][39] and to physicians [40,41].…”

Section: Discussionmentioning

confidence: 99%

Four Years Analysis of Cancer Genetic Clinics Activity in France from 1994 to 1997: A Survey on 801 Patients

et al. 1999

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AIM: In order to evaluate the characteristics and the evolution of cancer genetics activity in France, a survey was conducted at the national level during a period of 4 years from 1994 to 1997 through the French Cooperative Network, a multidisciplinary group formed to investigate inherited tumors.METHOD: A questionnaire was sent to all the 29 French non-specialized cancer genetic clinics to evaluate activity during a period of 4 consecutive weeks each year from 1994 to 1997. Items concerning the cancer genetic clinics, the consultees and the types of consultation were explored.RESULTS: A total number of 801 consultees were seen during the period of analysis. Some prominent characteristics of patients attending cancer genetic clinics were found. The majority of these are women (88%), and the mean age of consultees is 48 years. Fifty five percent of consultees are affected with cancer, and breast (personal and/or family history) is the most frequent site involved (63%). A genetic predisposition is certain or likely in about 53% of cases and unlikely in only 13% of consultations. The majority of consultations are devoted to new families (71%). The mean duration of consultations is 50 minutes, but 40% have a duration of at least 1 hour. Variations of several parameters during the 4 years period were observed and analyzed. Finally, since duration of consultations (more or equal to 1 hour) and personal or family history of breast/ovarian cancer appeared as pivotal elements in our study and consequently may affect the organization of clinics and the structuring as well as the evolution of cancer genetic activity in France, we analyzed more precisely the factors significantly associated with these 2 elements.CONCLUSION: Study compliance was fair (60% of centers) and these results give a good measure of cancer genetic activity in France. The variation of parameters from one year to another may reflect modifications in medical practice (medical orientation rather than research focus and content of cancer genetic clinics) and/or scientific breakthroughs in cancer genetics such as identification of genes predisposing to cancer.

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Acceptable Strategies for Dealing With Hereditary Breast/Ovarian Cancer Risk

Cited by 15 publications

References 6 publications

Disclosure to the family of breast/ovarian cancer genetic test results: Patient's willingness and associated factors

Disclosure to the family of breast/ovarian cancer genetic test results: Patient's willingness and associated factors

Disclosure of positive BRCA1/2-mutation status in young couples: The journey from uncertainty to bonding through partner support.

Four Years Analysis of Cancer Genetic Clinics Activity in France from 1994 to 1997: A Survey on 801 Patients

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