Acceptance of COVID-19 vaccine among healthcare workers in Africa, systematic review and meta-analysis

Figa, Zerihun; Temesgen, Tesfaye; Getnet, Addisu; Ganta, Moges; Alemu, Asrat; Abebe, Mesfin; Ashuro, Zemachu

doi:10.1016/j.puhip.2022.100343

Cited by 10 publications

(8 citation statements)

References 36 publications

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“…About 97% of the HCWs in our study believed the vaccine to be safe and effective. A systematic review and meta-analysis18 that assessed the vaccine acceptance in Africa showed that the acceptance rate for the vaccine’s safety and effectiveness was high in HCWs, which could explain the high vaccine uptake results in our study. Most (80%) HCWs had COVID-19 testing done before participating in our study.…”

Section: Discussionmentioning

confidence: 68%

Acceptance of COVID-19 vaccine and associated factors among healthcare workers in Katsina state: a cross-sectional study in Northwest Nigeria

Abubakar,

Suleiman,

Ahmad

et al. 2023

BMJ Open

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ObjectivesHealthcare workers were prioritised to receive the COVID-19 vaccine in Nigeria. Administration of COVID-19 vaccination in Nigeria was challenging because of a lack of trust in vaccine safety and vaccine effectiveness among healthcare workers, who are expected to provide reliable information about vaccines and vaccine-preventable diseases in the communities. Hence, their acceptance and attitudes towards COVID-19 preventive practices could influence the acceptance of the vaccine by the local population. This cross-sectional study assessed the acceptance of the COVID-19 vaccine among healthcare workers in Katsina State. We predicted the variables that increased the vaccine acceptance using logistic regression analysis.SettingThis hospital-based study was conducted at primary, secondary and tertiary healthcare facilities in Nigeria.ParticipantsA total of 793 healthcare workers were included in this study. Of these, 65.4% (n=519) were male.Outcome measuresTo assess acceptance of COVID-19 vaccine measures, and factors increasing acceptance among healthcare workers.ResultsOf the healthcare workers, 80% (638) were tested for the SARS-CoV-2, of whom 10.8% (n=65) tested positive. Approximately 97% (n=765) of them believed that the COVID-19 vaccine was safe, and 90% (n=714) received the first dose of the vaccine. Healthcare workers between 30 and 39 years were more likely to accept the vaccine (aOR: 7.06; 95% CI 2.36 to 21.07; p<0.001). Those who had been tested for COVID-19 were more likely (aOR:7.64; 95% CI 3.62 to 16.16; p<0.001) to accept the vaccine.ConclusionsOur findings showed that the age and prior COVID-19 testing were the main factors influencing the acceptance of the COVID-19 vaccine. There was high acceptance of the COVID-19 vaccine among healthcare workers in Katsina State, Nigeria. Future studies should focus on the completion of doses and serological testing for immunity.

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Section: Discussionmentioning

confidence: 68%

Acceptance of COVID-19 vaccine and associated factors among healthcare workers in Katsina state: a cross-sectional study in Northwest Nigeria

Abubakar,

Suleiman,

Ahmad

et al. 2023

BMJ Open

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“…Engaging pediatricians and child health care providers in vaccine advocacy can potentially alleviate parental apprehensions and foster trust. The high heterogeneity observed across studies denotes the existence of multiple influencing factors, including cultural, socioeconomic, educational, and individual beliefs, which vary extensively within and across populations [ 101 , 102 ]. The variations may also reflect the differences in study designs, populations, and time frames, emphasizing the need for standardization in future research to facilitate comparability and generalizability [ 103 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine Hesitancy: Umbrella Review of Systematic Reviews and Meta-Analysis

Rahbeni,

Satapathy,

Itumalla

et al. 2024

JMIR Public Health Surveill

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Background The unprecedented emergence of the COVID-19 pandemic necessitated the development and global distribution of vaccines, making the understanding of global vaccine acceptance and hesitancy crucial to overcoming barriers to vaccination and achieving widespread immunization. Objective This umbrella review synthesizes findings from systematic reviews and meta-analyses to provide insights into global perceptions on COVID-19 vaccine acceptance and hesitancy across diverse populations and regions. Methods We conducted a literature search across major databases to identify systematic reviews and meta-analysis that reported COVID-19 vaccine acceptance and hesitancy. The AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews) criteria were used to assess the methodological quality of included systematic reviews. Meta-analysis was performed using STATA 17 with a random effect model. The data synthesis is presented in a table format and via a narrative. Results Our inclusion criteria were met by 78 meta-analyses published between 2021 and 2023. Our analysis revealed a moderate vaccine acceptance rate of 63% (95% CI 0.60%-0.67%) in the general population, with significant heterogeneity (I2 = 97.59%). Higher acceptance rates were observed among health care workers and individuals with chronic diseases, at 64% (95% CI 0.57%-0.71%) and 69% (95% CI 0.61%-0.76%), respectively. However, lower acceptance was noted among pregnant women, at 48% (95% CI 0.42%-0.53%), and parents consenting for their children, at 61.29% (95% CI 0.56%-0.67%). The pooled vaccine hesitancy rate was 32% (95% CI 0.25%-0.39%) in the general population. The quality assessment revealed 19 high-quality, 38 moderate-quality, 15 low-quality, and 6 critically low-quality meta-analyses. Conclusions This review revealed the presence of vaccine hesitancy globally, emphasizing the necessity for population-specific, culturally sensitive interventions and clear, credible information dissemination to foster vaccine acceptance. The observed disparities accentuate the need for continuous research to understand evolving vaccine perceptions and to address the unique concerns and needs of diverse populations, thereby aiding in the formulation of effective and inclusive vaccination strategies. Trial Registration PROSPERO CRD42023468363; https://tinyurl.com/2p9kv9cr

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“…It is worrisome that COVID-19 vaccine acceptance is not only low among the general population but also among healthcare workers (HCWs). A systematic review and meta-analysis involving 23,739 African HCWs found that COVID-19 vaccine acceptance among African HCWs was only 56.59 (95%CI; 46.26-66.92; I2 = 99.6%, p = 0.000) ( 118 ).…”

Section: The Effect Of Bcg On Coronavirus Infectionsmentioning

confidence: 99%

Research progress on specific and non-specific immune effects of BCG and the possibility of BCG protection against COVID-19

Su²,

Wang³

et al. 2023

Front. Immunol.

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Bacille Calmette-Guérin (BCG) is the only approved vaccine for tuberculosis (TB) prevention worldwide. BCG has an excellent protective effect on miliary tuberculosis and tuberculous meningitis in children or infants. Interestingly, a growing number of studies have shown that BCG vaccination can induce nonspecific and specific immunity to fight against other respiratory disease pathogens, including SARS-CoV-2. The continuous emergence of variants of SARS-CoV-2 makes the protective efficiency of COVID-19-specific vaccines an unprecedented challenge. Therefore, it has been hypothesized that BCG-induced trained immunity might protect against COVID-19 infection. This study comprehensively described BCG-induced nonspecific and specific immunity and the mechanism of trained immunity. In addition, this study also reviewed the research on BCG revaccination to prevent TB, the impact of BCG on other non-tuberculous diseases, and the clinical trials of BCG to prevent COVID-19 infection. These data will provide new evidence to confirm the hypotheses mentioned above.

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Acceptance of COVID-19 vaccine among healthcare workers in Africa, systematic review and meta-analysis

Cited by 10 publications

References 36 publications

Acceptance of COVID-19 vaccine and associated factors among healthcare workers in Katsina state: a cross-sectional study in Northwest Nigeria

Acceptance of COVID-19 vaccine and associated factors among healthcare workers in Katsina state: a cross-sectional study in Northwest Nigeria

COVID-19 Vaccine Hesitancy: Umbrella Review of Systematic Reviews and Meta-Analysis

Research progress on specific and non-specific immune effects of BCG and the possibility of BCG protection against COVID-19

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