Notwithstanding the definition we choose, sepsis-associated short-term and long-term mortality and morbidity remain a major public health concern. From a high-income country perspective, the half-full glass (as shown by a sustained decline in mortality 1,2 ) is counterbalanced by the half-empty glass in which the high burden of long-term cognitive and functional decline seen in survivors of long-term sepsis 3 is increasingly recognised. However, in low-income and middle-income countries, the growing evidence base obtained from recent epidemiological studies of sepsis leaves us far from optimistic. At a quick glance, the well-designed study by Flavia R Machado and colleagues 4 shows that sepsis still has an ominous prognosis in patients admitted to a national-representative cohort of Brazilian intensive-care units (ICUs), with hospital mortality rates of 55%. Even for basic therapies such as antimicrobials, there remains a large variation in availability, with many hospitals having suboptimal provision. In Brazilian ICU settings where good standards of care are provided, recent data show that sustained efforts to implement best practices with increased sepsis awareness are associated with decreased mortality rates and costs. 5,6