“…DCL moves through a pathway taking advantage of temporarily increased local space due to natural protein breathing motions, which may be further enhanced by a DCL molecule. This is in agreement with studies describing the accessibility of pathways that are being controlled locally by (i) hydrogen-bonding and salt link interactions, described for cytochrome P450 14,16,[43][44][45][59][60][61][62] and acetylcholinesterase, 63,64 and (ii) aromatic gating, described for cytochrome P450, 14,16,42,43 acetylcholinesterase, 4,64-67 NADH oxidase, 19 horseradish peroxidase, 68,69 and myoglobin. 70 …”