2020
DOI: 10.1021/acsomega.0c02282
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Accessing the Ene–Imine Motif in 1H-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks

Abstract: A pathway to a range of diverse heterocycles was developed using a nucleophilic cyclization strategy. Lactams and ene-imines are accessed in a few steps from a common precursor, and these moieties are further elaborated to directly provide pyrroles or pyridines with extended conjugation. Reaction conditions are mild, and a broad range of structural types are available within a few steps.

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