1984
DOI: 10.1084/jem.159.6.1637
|View full text |Cite
|
Sign up to set email alerts
|

Accessory cell function of human B cells. I. Production of both interleukin 1-like activity and an interleukin 1 inhibitory factor by an EBV-transformed human B cell line.

Abstract: In the present paper we report that the ROHA -9 cell line, an Epstein-Barr virus (EBV)-transformed human B cell line with accessory cell capabilities, constitutively secretes a soluble factor with the biochemical and biological characteristics of human monocyte-derived IL-1. The IL-1 derived from ROHA -9 augmented murine thymocyte proliferation and enhanced the proliferative response of human T lymphocytes to concanavalin A (Con A). The ROHA -9-derived IL-1 activity eluted from Sephacryl S-200 in two peaks, at… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
43
0

Year Published

1985
1985
1990
1990

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 179 publications
(46 citation statements)
references
References 32 publications
3
43
0
Order By: Relevance
“…ADF could, thus, act as a competence factor, allowing a cell to become sensitive to suboptimal amounts of other growth factors. The role of IL-1 as a putative autocrine growth factor for EBV-infected B cells (17) and HTLV-I+ T cells (18) has already been suggested, although an actual autocrine loop could only be demonstrated in a few cases. On the other hand, involvement of the IL-2/IL-2R autocrine system in the development of adult T-cell leukemia by HTLV-I has been hypothesized.…”
Section: Resultsmentioning
confidence: 99%
“…ADF could, thus, act as a competence factor, allowing a cell to become sensitive to suboptimal amounts of other growth factors. The role of IL-1 as a putative autocrine growth factor for EBV-infected B cells (17) and HTLV-I+ T cells (18) has already been suggested, although an actual autocrine loop could only be demonstrated in a few cases. On the other hand, involvement of the IL-2/IL-2R autocrine system in the development of adult T-cell leukemia by HTLV-I has been hypothesized.…”
Section: Resultsmentioning
confidence: 99%
“…and purified material (13,(14)(15)(16)(17)(18)(19)(20)(21)(22). However, these inhibitors found in vivo did not seem to affect MCF/IL-1 as defined by PGE2 production-stimulating activity (23).…”
Section: Methodsmentioning
confidence: 99%
“…In addition to the absence ofinhibitory activity against MCF/IL-l by the urine-derived LAF/IL-l inhibitor described by others (23) there was already evidence that the LAF/IL-l inhibitor(s) was not active in the MCF/IL-I bioassay. It has been shown that the production of LAF/IL-l was hampered by inhibitors in supernatants of U937 monocytic cell line, but in contrast the MCF/ IL-l activity was not overcome by these LAF/IL-1 inhibitors (16)(17)(18). This indicates that the urinary inhibitor(s) found in our study is different from the one produced by U937 cells or described in urine (23) or liver extracts (26).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The best known IL-1 producer cells are monocytes/macrophages, B cells (Scala et al, 1984) and epidermal cells (Luger et al, 1985). Production of IL-1 by cells of the T cell lineage has also been reported (Tartakovsky et al, 1986).…”
Section: Introductionmentioning
confidence: 97%