Accident vasculaire cérébral ischémique, complication inhabituelle d’une morsure de vipère: à propos d’un cas

Assamadi, M.; M'Barek, Yassine Ait; Elallouchi, Y.; Benantar, L.; Aniba, K.

doi:10.11604/pamj.2022.41.50.22225

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…The cause of the abdominal pain was identified as acute mesenteric and bowel ischaemia, as evidenced on CT scan. Although the mechanism is not fully understood, the prothrombotic effects of venom proteins are thought to increase platelet activity through the formation of distal microthrombi and visceral infarctions [ 66 ]. Although the patient had antivenom administered, surgery was performed, and the patient made a full recovery [ 65 ].…”

Section: Rare Presentations and Poor Outcomesmentioning

confidence: 99%

Clinical Risk Factors Associated with Poor Outcomes in Snake Envenoming: A Narrative Review

Wood

2023

Toxins

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Snakebite-related fatalities disproportionately affect populations in impoverished socio-economic regions, marked by limited access to adequate healthcare and constrained antivenom availability. Early medical intervention is pivotal in mitigating mortality and morbidity associated with snakebite envenoming (SBE). While clinical assessment remains fundamental in treating SBE, this review aims to spotlight objective parameters that could also affect outcomes. Selected studies that identify factors associated with poor outcomes are predominantly region-specific, single-site, and observational, yet collectively reveal similar findings. They consistently report factors such as treatment delays, susceptibility in vulnerable groups such as children and pregnant women, as well as various biochemical and haematological abnormalities. Acute kidney injury (AKI), low platelets, leucocytosis, abnormal coagulation, and elevated creatine kinase (CK) all show an association with poor outcomes. Furthermore, recognising rare and unusual SBE presentations such as adrenal insufficiency, severe hypertension, intracranial haemorrhage, acute angle closure glaucoma, and bowel ischaemia also has a bearing on outcomes. Despite the integration of these parameters into clinical decision tools and guidelines, the validation of this evidence is limited. This review underscores the imperative for high-quality, multi-centre studies aligned with consensus-driven Core Outcome Sets (COS) and Patient-Reported Outcome Measures (PROMS) to validate and strengthen the current evidence.

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Section: Rare Presentations and Poor Outcomesmentioning

confidence: 99%

Clinical Risk Factors Associated with Poor Outcomes in Snake Envenoming: A Narrative Review

Wood

2023

Toxins

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“…Neurological disorders are exceptional. They may be secondary either to circulatory failure following acute hypotension due to arterial and/or haematological vasodilatation following vasospasm due to perivascular bleeding, or to the direct action of the neurotoxic venom of certain populations of vipers [4] .…”

Section: Introductionmentioning

confidence: 99%

Disseminated Intravascular Coagulation and Ischemic Stroke due to Snake Bites: About One Case

Lagdani,

Hayate,

Manel

et al. 2024

ijirms

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Snake bites are responsible for a high rate of mortality in Africa. There are multiple problems in the early treatment of victims. The overall mortality from these bites is 4%. Viper bites are known to cause coagulopathy leading to organ and/or system failure with muscle paralysis, respiratory failure, circulatory instability, acute kidney injury and local disability, compartment syndrome and necrosis. Disseminated intravascular coagulation and ischaemic stroke is an extremely rare complication of snakebite that can be fatal if treatment is delayed. Here we present A 15-year-old patient with no history of viper envenomation who consulted our emergency department after an accidental viper bite to the index finger of his left hand rapidly developed extensive oedema, necrosis, haemorrhagic shock are presenting in a state of coma and refractory shock. A CT scan of the brain showed meningeal haemorrhages, intracerebral haematomas and diffuse ischaemic lesions. The laboratory results showed abnormalities such as anaemia, thrombocytopenia, hypofibrinogenemia and elevated D-dimer levels. The patient died of disseminated intravascular coagulation (DIC), which developed within 12 hours of being bitten by a snake. Snakebites can cause DIC because the venom activates the coagulation system and causes fibrinolysis, which occurs in less than 24 hours. A nationwide protocol of management, including specific antivenom therapy and prevention strategies, has been implemented to reduce the overall morbidity and mortality of snakebites.

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Polyvalent-snake-antivenin

2022

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Accident vasculaire cérébral ischémique, complication inhabituelle d’une morsure de vipère: à propos d’un cas

Cited by 4 publications

References 5 publications

Clinical Risk Factors Associated with Poor Outcomes in Snake Envenoming: A Narrative Review

Clinical Risk Factors Associated with Poor Outcomes in Snake Envenoming: A Narrative Review

Disseminated Intravascular Coagulation and Ischemic Stroke due to Snake Bites: About One Case

Polyvalent-snake-antivenin

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