Food poisoning is one of the common health problems in most "frican countries. This review was conducted to describe the situation in "frica with regard to specific risk factors and outcomes of food poisoning in the "frican setting based on published literature.It is noted that food poisoning in "frica involves the staple foods used throughout the continent, but due to lack of surveillance systems, the actual burden of food poisoning is unknown. While the general mechanisms of food poisoning apply to the "frican settings, inherent issues specific to the "frican context include macro-environmental issues such as infrastructural problems, inadequate policy environment and lack of regulatory food control systems, leading to unsafe foods being sold in the streets. In addition, individual sociodemographic factors, including the age, gender, health status and lack of food safety knowledge among the population and food handlers and preparers, as well as the country s contextual factors such as unsafe harvesting practices, are all associated with the occurrence of food poisoning in "frica."lso due to a lack of surveillance systems and population-based studies, the outcomes of food poisoning are not adequately documented. It is clear that food poisoning is responsible for a significant number of health facility visits and hospitalisations as well as deaths. Moreover, several long-term effects such as cancers and other conditions affecting children, pregnant women and the elderly have been also reported.To conclude, food poisoning is one of the major causes of morbidity in "frica. Several risk factors influence its occurrence. It is recommended that the control systems that are lacking should be instituted and that public education should be conducted so that hygienic and safe food handling practices can be implemented. Moreover, the preservation of the sources of food, namely the fauna and flora ecosystems, as well as environmental media, namely air, soil and water, should be considered not only as a necessity but as a shared responsibility that each human being should accept every day in the way he or she lives, make decisions and eat.