Accidental kidney biopsies in psoriasis

Abstract

Eight accidental kidney biopsies in psoriatics were obtained together with 429 liver biopsies. None of the biopsies showed signs of renal damage. All patients had severe psoriasis, six had been treated with methotrexate for 1-2-6 years, receiving total dosages from 660 to 1757 g.

Renal Abnormalities in Psoriatic Patients: A Review

“…Zachariae et al [25, 26]were unable to detect either functional or morphologic renal alterations in 19 methotrexate-treated psoriatics.…”

“…Zachariae et al [25, 26]report a normal kidney histology in psoriatic patients in two different studies. Semiquantitative evaluation of interstitial fibrosis and arteriolar hyalinosis as well as interstitial volume, estimated by morphometry showed no significant changes.…”

“…In both studies little information is given on previous, potentially nephrotoxic medications. Microvascular disturbances, similar to those in the skin have never been demonstrated by kidney biopsies [25, 26, 37]. Further investigations on the excretion of urinary enzymes could therefore reveal important information, both in untreated and in psoriatic patients treated with potentially nephrotoxic drugs.…”

“…In the few studies where kidney biopsies were performed in psoriatic patients who never received nephrotoxic medication, no structural lesions were found [25, 26, 37]. On the other hand CsA-related nephrotoxicity has been proven histologically in psoriatic patients even treated at low dose [36].…”

Reversal of Nephrotic Syndrome due to AA Amyloidosis in Psoriatic Patients on Long-Term Colchicine Treatment

“…Studies of kidney biopsies from patients with severe psoriasis showed that almost all biopsies were considered normal [37, 38]. Only psoriatics on cyclosporine A treatment for more than 2 years showed the development of cyclosporine nephrotoxicity [39].…”