Accidental paraquat induced hypersalivation: a case report

Anusha, J Bhaavya; Moudgil, Khayati

doi:10.1007/s40199-019-00298-9

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…On the other hand, paraquat (B) is highly toxic in humans. It is rapidly absorbed and it bioaccumulates in lipid compartments ( Figure 2 ) [ 61 ]. Thus, it may have an affinity for the lamina propria, thereby altering its structural integrity as well as the host immune response.…”

Section: General Effects Of Pesticides On the Oral Cavitymentioning

confidence: 99%

“…In the search for databases, we found 5 cases of subjects exposed to paraquat by accident ( Table 3 ). In all cases, it was reported that paraquat increased the release of ROS due to mitochondrial damage, which induced oxidation of lipids, proteins, and nucleic acids, in addition to increase inflammatory responses, and in some cases, apoptosis, which led to the development of ulcers of the oral mucosa and bleeding [ 61 , 62 , 63 , 64 , 65 ]. The increases in oxidative stress and inflammation are responses that were also observed in a murine model exposed to paraquat, and they are very similar to those seen in the pathology of periodontitis with loss of the alveolar bone [ 52 ].…”

Section: General Effects Of Pesticides On the Oral Cavitymentioning

confidence: 99%

“…Studies have shown that pesticides inhibited muscarinic and nicotinic receptors, resulting in xerostomia, a risk factor for the development of dental caries, oral infections, and mucosal inflammation [ 28 , 32 , 34 , 53 ]. On the other hand, increased immune response and tissue damage from pesticide exposure led to hypersalivation [ 61 ]. Any modification in the quality and quantity of saliva has an impact on the wound healing process, mineralization, and microbial protection [ 30 ].…”

Section: General Effects Of Pesticides On the Oral Cavitymentioning

confidence: 99%

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Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review

Salazar-Flores

Martínez

Ceja-Gálvez

et al. 2022

IJERPH

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Pesticides are chemical substances used to control, prevent, or destroy agricultural, domestic, and livestock pests. These compounds produce adverse changes in health, and they have been associated with the development of multiple chronic diseases. This study aimed to present a detailed review of the effect of pesticides on the oral cavity and the oral microbiome. In the oral cavity, pesticides alter and/or modify tissues and the microbiome, thereby triggering imbalance in the ecosystem, generating an inflammatory response, and activating hydrolytic enzymes. In particular, the imbalance in the oral microbiome creates a dysbiosis that modifies the number, composition, and/or functions of the constituent microorganisms and the local response of the host. Pesticide exposure alters epithelial cells, and oral microbiota, and disrupts the homeostasis of the oral environment. The presence of pesticides in the oral cavity predisposes the appearance of pathologies such as caries, periodontal diseases, oral cancer, and odontogenic infections. In this study, we analyzed the effect of organochlorines, organophosphates, pyrethroids, carbamates, bipyridyls, and triazineson oral cavity health and ecosystems.

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Section: General Effects Of Pesticides On the Oral Cavitymentioning

confidence: 99%

Section: General Effects Of Pesticides On the Oral Cavitymentioning

confidence: 99%

Section: General Effects Of Pesticides On the Oral Cavitymentioning

confidence: 99%

See 1 more Smart Citation

Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review

Salazar-Flores

Martínez

Ceja-Gálvez

et al. 2022

IJERPH

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“…However, PQ is highly toxic to humans, and it is a common poison in suicide and accidental poisoning [ 2 ]. In the early stage, PQ poisoning can cause acute lung injury or acute respiratory distress syndrome, and most patients die of multi-organ dysfunction syndrome (MODS) or respiratory failure, whose pathogenesis is still unclear [ 3 , 4 ]. At present, there is no specific detoxification drug for paraquat poisoning, and the clinical treatment is still under exploration.…”

Section: Introductionmentioning

confidence: 99%

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Guo

Gao

2023

Molecules

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Paraquat (PQ) and diquat (DQ) are quaternary ammonium herbicides which have been used worldwide for controlling the growth of weeds on land and in water. However, PQ and DQ are well known to be toxic. PQ is especially toxic to humans. Moreover, there is no specific antidote for PQ poisoning. The main treatment for PQ poisoning is hemoperfusion to reduce the PQ concentration in blood. Therefore, it is essential to be able to detect PQ and DQ concentrations in biological samples. This critical review summarizes the articles published from 2010 to 2022 and can help researchers to understand the development of the sample treatment and analytical methods for the determination of PQ and DQ in various types of biological samples. The sample preparation includes liquid–liquid extraction, solid-phase extraction based on different novel materials, microextration methods, and other methods. Analytical methods for quantifying PQ and DQ, such as different chromatography and spectroscopy methods, electrochemical methods, and immunological methods, are illustrated and compared. We focus on the latest advances in PQ and DQ treatment and the application of new technologies for these analyses. In our opinion, tandem mass spectrometry is a good choice for the determination of PQ and DQ, due to its high sensitivity, high selectivity, and high accuracy. As far as we are concerned, the best LOD of 4 pg/mL for PQ in serum can be obtained.

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Tenascin-C Participates Pulmonary Injury Induced by Paraquat Through Regulating TLR4 and TGF-β Signaling Pathways

Zhang

Liu

et al. 2021

Inflammation

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Accidental paraquat induced hypersalivation: a case report

Cited by 5 publications

References 4 publications

Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review

Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Tenascin-C Participates Pulmonary Injury Induced by Paraquat Through Regulating TLR4 and TGF-β Signaling Pathways

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