Accumulation and Clearance of Orally Administered Erythromycin in Adult Nile Tilapia (<i>Oreochromis niloticus</i>) and Giant Freshwater Prawn (<i>Macrobrachium rosenbergii</i>)

Minh, Nguyễn Phước; Lam, T. B.; Giao, Nguyen Trong; Quan, Ni

doi:10.1080/10454438.2012.678782

Cited by 3 publications

(3 citation statements)

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“…In Nile tilapia ( Oreochromis niloticus L.) Minh et al . () observed, 1 day after treatment with 50 and 100 mg kg −1 b.w. day −1 of ERY for 7 days, tissue concentrations of ERY equal to 22.216 ± 22.02 and 46.96 ± 9.05 μg g, −1 respectively; 9 days after the end of treatment, ERY concentrations decreased to 0.131 ± 0.032 and 0.379 ± 0.099 μg g −1 , respectively.…”

Section: Discussionmentioning

confidence: 97%

Pharmacokinetics and residue depletion of erythromycin in rainbow trout Oncorhynchus mykiss (Walbaum)

Salvo

Rocca

Cagnardi

et al. 2013

Journal of Fish Diseases

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Erythromycin (ERY) is a drug active against Gram-positive bacteria such as Lactococcus garvieae, a pathogen responsible for an important disease that may cause a substantial decrease in rainbow trout Oncorhynchus mykiss (Walbaum) production, the species of fish most commonly produced in Italy. In the literature, studies on the kinetics behaviour of ERY in fish are limited. Therefore, the aim of the present study was to evaluate the pharmacokinetics of ERY in rainbow trout after a single oral treatment with 75 mg kg⁻¹ body weight (b.w.) of ERY and the residue depletion after multiple oral administration of 75 mg kg⁻¹ b.w. day⁻¹ of ERY for 10 days. Blood concentrations of ERY increased up to 20.24 ± 13.32 μg mL⁻¹ at 6 h, then decreased to 5.97 ± 3.89 μg mL⁻¹ at 24 h. The time during which the antibiotic remains in the bloodstream at concentrations exceeding the MIC (T > MIC) and the area under the serum concentration-time curve (AUC)/MIC are both pharmacokinetic-pharmacodynamic (PK/PD) predictors of ERY efficacy, and the data obtained allowed us to hypothesize that a dosage of 75 mg kg⁻¹ b.w. day⁻¹ of ERY could treat the lactococcosis in trout. Regarding the study of ERY depletion, rapid elimination was observed in tissue (muscle plus adherent skin); in fact the concentrations were below the limit of quantification in all samples (except two) by day 10 post-treatment. ERY is not licensed in Europe for use in aquaculture, and its use is possible only by off-label prescription with a precautionary withdrawal time of 500 degree-days, as established by Directive 2004/28/EC. From the data obtained in this study, a withdrawal time of 8.90 days was calculated, corresponding, in our experimental conditions, to 117.5 degree-days, a value significantly lower than that established by the European directive.

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Section: Discussionmentioning

confidence: 97%

Pharmacokinetics and residue depletion of erythromycin in rainbow trout Oncorhynchus mykiss (Walbaum)

Salvo

Rocca

Cagnardi

et al. 2013

Journal of Fish Diseases

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“…Through the study, the withdrawal time (WDT) suggested was 33 days in crucian carp muscle, whereas the minimum withdrawal time of 9 days in chicken muscle . Compared with other macrolides, the WDT of TLM was longer than erythromycin in rainbow trout, Nile tilapia and gilthead sea bream (Esposito et al, 2007;Minh et al, 2011;Salvo et al, 2013), azithromycin in juvenile fall Chinook salmon (Fairgrieve et al, 2005). In contrast, Minh et al (2010) observed a greater decrease in erythromycin concentrations in giant freshwater prawn (Macrobrachium rosenbergii) than TLM in crucian carp (Minh et al, 2010).…”

Section: Discussionmentioning

confidence: 98%

Pharmacokinetic Profile and Muscle Residue Elimination of Tilmicosin after Oral Administration in Crucian Carp (Carassius auratus)

Yang¹,

Li²,

Ai³

et al. 2014

Israeli Journal of Aquaculture - Bamidgeh

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As from January 2010 The Israeli Journal of Aquaculture -Bamidgeh (IJA) will be published exclusively as an on-line Open Access (OA) quarterly accessible by all AquacultureHub (http://www.aquaculturehub.org) members and registered individuals and institutions. Please visit our website (http://siamb.org.il) for free registration form, further information and instructions.This transformation from a subscription printed version to an on-line OA journal, aims at supporting the concept that scientific peer-reviewed publications should be made available to all, including those with limited resources. The OA IJA does not enforce author or subscription fees and will endeavor to obtain alternative sources of income to support this policy for as long as possible.

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“…Minh et al . () observed the presence of residues of ERY in muscle of Nile tilapia up to 23 days after administration of the drug at 50 and 100 mg Kg −1 b.w. day −1 for 7 days.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and residue depletion of erythromycin in gilthead sea bream Sparus aurata L. after oral administration

Salvo

Pellegrino

Cagnardi

et al. 2013

Journal of Fish Diseases

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Erythromycin (ERY) is an antibiotic effective against Streptococcus iniae, a microorganism responsible for significant losses in aquaculture. No data are available on the pharmacokinetics and residue depletion of ERY in sea bream. The aim of this study was thus to evaluate the pharmacokinetics of ERY in this species after a single oral administration at 75 mg kg(-1) b.w. and to assess its residue depletion from tissues after prolonged treatment for 10 days. ERY was rapidly absorbed in sea bream (Cmax = 10.04 μg g(-1) and Tmax =1 h), with a half-life of 9.35 h and an AUC0-24 of 56.81 (h μg mL(-1) ). The data obtained and the evaluation of pharmacokinetic/pharmacodynamic parameters allowed us to hypothesize that dosage used in this study should be effective against S. iniae. A rapid reduction in erythromycin concentrations was observed in tissues, with the drug being detectable only during the first day post-treatment. In Europe, the use of ERY in aquaculture is allowed by off-label prescription with a withdrawal time of 500 °C day(-1) . The absence of ERY residues in tissues already at 24 h post-treatment suggests that ERY in sea bream should not pose human food safety issues.

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Accumulation and Clearance of Orally Administered Erythromycin in Adult Nile Tilapia (Oreochromis niloticus) and Giant Freshwater Prawn (Macrobrachium rosenbergii)

Cited by 3 publications

References 0 publications

Pharmacokinetics and residue depletion of erythromycin in rainbow trout Oncorhynchus mykiss (Walbaum)

Pharmacokinetics and residue depletion of erythromycin in rainbow trout Oncorhynchus mykiss (Walbaum)

Pharmacokinetic Profile and Muscle Residue Elimination of Tilmicosin after Oral Administration in Crucian Carp (Carassius auratus)

Pharmacokinetics and residue depletion of erythromycin in gilthead sea bream Sparus aurata L. after oral administration

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