Accumulation of 8‐methoxypsoralen in the Rat Retina

Wulf, Hans Christian; Hart, J. W.

doi:10.1111/j.1755-3768.1978.tb01354.x

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1979

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Cited by 9 publications

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“…We have earlier de,cribed how 8-MOP i, distri buted in thc rat eye (30). In the present article wc de,cribe the organ distribution of tritium-labelled 8-\IOP in albino and pigmented rats u�ing whole body autoradiograph>.…”

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confidence: 82%

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Distribution of tritium-labelled 8-methoxypsoralen in the rat, studied by whole body autoradiography

Hc¹,

Hart²

1979

Acta Derm Venereol

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The distribution of 3H-8-methoxypsoralen has been studied in rats by whole body autoradiography. The highest organ concentration were seen 1 hour after dosing. The most pronounced accumulation was found centriblobular in the liver, corticomedullary in the kidneys, and in the cortex of the adrenals. The concentrations in these organs were approximately six times higher than in the blood. Other organs showed concentrations similar to blood levels. Illumination with UVA (10 J/cm2) increased the concentrations in the subcutis.

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“…The lack of difference between albino and pigmented rats is surprising in view of the melanin binding found in the rat eye (30). It is possible that the compound has an affinity for the melanocytes around the hair follicles, irrespective of their pigmentation.…”

Section: Skinmentioning

confidence: 99%