Accumulation of cadmium and its effects on liver and kidney functions in rats given diet containing cadmium-polluted radish bulb

Haouem, Samir; Hmad, Najla; Najjar, Mohamed Fadhel; Hani, Abdelhamid El; Sakly, R

doi:10.1016/j.etp.2007.03.006

Cited by 35 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence meaningful effects on body weight gain may only occur after exposure to very high doses of Cd in drinking water. The lack of significant (P [ 0.05) body weight change (Table 2) in rats fed Cd supplemented diet for 1 month relative to the pair-fed controls is in harmony with the reports of Haouem et al (2007). These workers results indicate that rats given diet containing Cd-polluted radish bulb (1.1 microgram Cd/g of diet) had identical weight gain relative to controls.…”

Section: Discussionsupporting

confidence: 94%

Comparative effect of water and food-chain mediated cadmium exposure in rats

Asagba

2010

Biometals

View full text Add to dashboard Cite

This study sets out to compare the absorption and toxicity of Cadmium (Cd) administered via the food-chain and inorganic Cd administered in drinking water after 1 and 3 months exposure using rats as animal model. The food-chain was mimicked by exposing rats to diet containing Cd pre-exposed fish. The uptake of Cd by the rats after both mode of exposure was calculated by summing up the Cd burden in the liver and kidneys and was expressed in terms of % intake. The toxicity of Cd was assessed by monitoring biochemical indices of liver function in the plasma and liver. Regardless of the mode of exposure of the rats, the Cd load in the liver and kidney was significantly (P < 0.05) higher than the respective controls with the kidney having a significantly higher load than the liver after both periods of exposure. However irrespective of the mode of exposure, more Cd was accumulated in the liver and kidney of the 3 months exposed rats relative to those exposed for 1 month. The uptake of Cd by rats exposed to Cd via the food-chain for 1 and 3 months was significantly (P< 0.05) lower when compared to the corresponding water mediated Cd exposed rats, except for the liver after 3 months of exposure. The liver L-ALT activity of rats administered inorganic Cd in drinking water for 1 and 3 months was significantly (P < 0.05) lower as compared to controls. Parallel analysis of the plasma showed no significant (P > 0.05) difference in L-ALT activity between both groups after the same periods of exposure. The L-AST activity in the plasma of rats similarly exposed to Cd for 1 and 3 months was significantly (P < 0.05) higher as compared to controls with a corresponding reduction in the liver. Conversely no significant (P > 0.05) change was observed in plasma and liver L-ALT and L-AST activities after food-chain mediated exposure to Cd for 1 and 3 months in relation to their respective controls. These findings indicate that Cd incorporated in fish is more easily bioavailable, but less toxic relative to inorganic Cd salts at the end of 3 months of exposure in rats.

show abstract

Section: Discussionsupporting

confidence: 94%

Comparative effect of water and food-chain mediated cadmium exposure in rats

Asagba

2010

Biometals

View full text Add to dashboard Cite

show abstract

“…The result showed that maximum level of cadmium accumulated in the kidney and liver up to at 75 mg/kg of CdCl 2 in the medicated groups. This result is also in accord with previous result, suggesting that kidney and liver is the main organ for the accumulation of heavy metals (Haouen et al ., 2007). At high doses the level of the accumulated cadmium increased in the breast muscles and tended to decreased in the kidney and lever by increasing the secretion.…”

Section: Discussionsupporting

confidence: 94%

Determination of Optimal Toxic Concentration and Accumulation of Cadmium in Broiler Chicks

Subhan¹,

Khan²,

Wahid³

et al. 2011

Toxicological Research

View full text Add to dashboard Cite

Cadmium is considered one of the most toxic, non biodegradable heavy metal for the human and animals. The purpose of the present study was to investigate the changes in biochemical parameters of blood and accumulation of cadmium in various tissue caused by various levels of dietary cadmium chloride (CdCl2) in broiler chicks. CdCl2 was administered through drinking water to broiler chicks. In spectral analysis, CdCl2 treatment caused a significant increase in Glutamate pyruvate transaminase (GPT), creatinine and uric acid levels in all treated groups. Intriguingly, the GPT, creatinine, and uric acid levels were significantly higher at 75 mg/kg as compared to the groups treated with high doses (100, 125 and 150 mg/kg) of CdCl2. Atomic Absorption Spectrophotometer (AAS) was used for the determination of Cd accumulation in kidney, liver and Breast muscles. AAS analysis revealed that Cd accumulation is increased in breast muscles as compared to liver and kidney at higher doses of Cd than 75 mg/kg.

show abstract

“…In addition, cadmium is irreversibly accumulated into cells, as it has been demonstrated in rat organs and marine mollusks (Roesijadi et al 1996;Haouem et al 2007). The mechanisms by which cadmium interacts with cellular components and molecular targets are probably various, though still poorly understood.…”

mentioning

confidence: 91%

Environmentally relevant cadmium concentrations affect development and induce apoptosis of Paracentrotus lividus larvae cultured in vitro

et al. 2008

View full text Add to dashboard Cite

Sea urchin embryos and larvae represent suitable model systems on where to investigate the effects of heavy metals on development and cell viability. Here, we tested the toxic effects of low (10(-12 )M), medium (10(-9 )M), and high (10(-6 )M) cadmium chloride concentrations, mimicking unpolluted, moderately and highly polluted seawaters, respectively, on Paracentrotus lividus sea urchins offspring. Larvae were continuously treated from fertilization and inspected at time intervals comprised between 10 and 30 days of development. Delays and/or morphological abnormalities were firstly evident in larvae treated for 15 days with high cadmium (10(-6 )M) and for 25 days with medium cadmium (10(-9 )M). Major defects consisted in the reduction and lack of arms and skeleton elongation. No obvious differences with respect to controls were observed in embryos/larvae exposed to low cadmium (10(-12) M), even after 30 days of exposure. Using in situ terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay (TUNEL) assay on larvae whole mounts, we detected apoptosis after 10 days of treatment with 10(-6) and 10(-9) M CdCl(2,) when no morphological abnormalities were recognizable yet. Supernumerary apoptotic cells were found in arm buds, ciliary bands, and apex. In conclusion, echinoderm embryos and larvae represent candidates of choice for the study of stress and defense mechanisms activated by cadmium exposure.

show abstract

Accumulation of cadmium and its effects on liver and kidney functions in rats given diet containing cadmium-polluted radish bulb

Cited by 35 publications

References 18 publications

Comparative effect of water and food-chain mediated cadmium exposure in rats

Comparative effect of water and food-chain mediated cadmium exposure in rats

Determination of Optimal Toxic Concentration and Accumulation of Cadmium in Broiler Chicks

Environmentally relevant cadmium concentrations affect development and induce apoptosis of Paracentrotus lividus larvae cultured in vitro

Contact Info

Product

Resources

About