Accumulation of two alkylating agents, nitrogen mustard and busulfan, by murine leukemia cells in vitro

Mechanism of resistance of yoshida sarcoma to nitrogen mustard

“…As to the problems of drug transport, Wheeler (1963) and Wheeler and Alexander (1 964), Kessel et al (1969), Harrap et al (1970), Poynter (1970), and Connors and Double (1970) did not find any marked difference between sensitive and resistant cell lines, but recently Rutman et al (1968), Klatt et al (1969), Wolpert et al (1969), and Chun et al (1969) reported their findings on the difference in drug transport between sensitive and resistant sublines of Ehrlich carcinoma. Similar results were also reported by Goldenberg et al (1970) with sensitive and resistant sublines of L5178Y lymphoblast.…”

“…Mechanisms of resistance to alkylating agents have been investigated extensively during the past few years, and discussions centered on the decrease of drug transport into cells through the cell membrane, enhancement of inactivation of a drug inside the cells (Calcutt and Connors, 1963), and activation of metabolism related to repair of damaged DNA (Crathorn and Roberts, 1966;Roberts et al, 1968). As to the problems of drug transport, Wheeler (1963) and Wheeler and Alexander (1 964), Kessel et al (1969), Harrap et al (1970), Poynter (1970), and Connors and Double (1970) did not find any marked difference between sensitive and resistant cell lines, but recently Rutman et al (1968), Klatt et al (1969), Wolpert et al (1969), and Chun et al (1969) reported their findings on the difference in drug transport between sensitive and resistant sublines of Ehrlich carcinoma. Similar results were also reported by Goldenberg et al (1970) with sensitive and resistant sublines of L5178Y lymphoblast.…”

Antineoplastic and Immunosuppressive Drugs1 I

“…Nitrogen mustard and busulphan rapidly penetrate tumour cells of widely differing sensitivities, but there is no direct correlation between drug accumulation and inhibition of nucleic acid synthesis (Kessel et al, 1969).…”