Accuracy and Precision of Intravitreally Injected Ranibizumab Doses: An Experimental Study

Gerding, H.; Timmermann, M.

doi:10.1055/s-0029-1245183

Cited by 11 publications

(10 citation statements)

References 6 publications

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“…Meyer et al postulier-ten außerdem, dass die unterschiedliche Häufigkeit der Augendruckanstiege in der regelrecht durchgeführten Präparation und dem Aufziehen der Medikamente in den dafür vorgesehenen Spritzen liegen kann [18]. Nur wenigen ist bekannt, dass allein die aufgedruckte Markierungslinie der nach ISO-Norm geeichten Tuberkulinspritzen eine Schwankungsbreite des Volumens von 2 % umfasst [19]. Dazu…”

Section: Therapieoptionen Und Risikobewertungunclassified

Sicherheit, Effektivität und protektive Wirkung einer Parazentese bei intravitrealen Injektionen: „Eine Lanze für die Parazentese brechen“

Koss

Bolz

Augustin

et al. 2019

Klin Monbl Augenheilkd

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Section: Therapieoptionen Und Risikobewertungunclassified

Sicherheit, Effektivität und protektive Wirkung einer Parazentese bei intravitrealen Injektionen: „Eine Lanze für die Parazentese brechen“

Koss

Bolz

Augustin

et al. 2019

Klin Monbl Augenheilkd

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“…15,16 Experimental injections on porcine eyes in this study were performed by clinicians using their normal clinical technique. The differential injection method used in our experiment has previously been found to be the most precise method for delivering the desired volume with a mean variation of less than 2%.…”

Section: Discussionmentioning

confidence: 99%

“…The differential injection method used in our experiment has previously been found to be the most precise method for delivering the desired volume with a mean variation of less than 2%. 15 …”

Section: Discussionmentioning

confidence: 99%

A Novel Method for the Measurement of Reflux from Intravitreal Injections: Data from 20 Porcine Eyes

Brodie¹,

Ruggiero²,

Ghodasra³

et al. 2013

Current Eye Research

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Background Reflux following intravitreal injection is a common phenomenon, but it is unknown how much, if any, medication is lost as a result. Reflux is known to be a combination of vitreous and the injected agent, but the relative composition is unknown. This paper describes a novel method for the measurement of the volume and composition of reflux and presents data from porcine eyes. Methods Twenty porcine eyes were injected with 0.05 ml of dye at intraocular pressures (IOPs) of 15, 20, 25 and 30 mmHg (5 eyes per subgroup). Reflux was captured on filter paper and the area of saturation and color intensity of the dye were digitally analyzed. Total refluxed volume and proportion of dye vs. vitreous fluid were calculated from linear regression lines created from known standards. Results Average (median) total volume of reflux from all eyes was 1.19 μL (0.93 μL), volume of injected dye refluxed was 0.47 μL (0.11 μL), and composition of reflux was 20.8% dye (15.5%). Less than 1% of the injected dye was lost to reflux. There were no differences between IOP groups in the total volume refluxed, the total amount of dye refluxed, the average composition of the reflux, or the amount of injected dye refluxed (df=3 for all comparisons; p=0.58, p=0.51, p=0.55, p=0.51, respectively). Conclusions This novel method allows for measurement of quantity and composition of reflux following intravitreal injection in vitro. While reflux occurs frequently, it is predominantly composed of vitreous, not the injected agent. In fact, less than one percent of the original injection was lost to reflux.

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“…One ranibizumab PFS contains 0.165 mL of ranibizumab, ensuring that one always has adequate volume to administer a single dose of 0.05 mL. Several studies have revealed considerable variability in the accuracy and repeatability achieved with typical syringes used for intravitreal injections 31–35. Most commonly used small-volume syringes tend to over deliver their target volume 33,35.…”

Section: Accuracy and Precision Of Intravitreal Ranibizumab Dosesmentioning

confidence: 99%

<p>Prefilled syringes for intravitreal drug delivery</p>

Sassalos¹,

Paulus²

2019

OPTH

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Intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications play an increasingly critical role in numerous retinal vascular diseases. Initially, anti-VEGF medications came in vials that had to be drawn up by the physician into a syringe for administration. In 2018, the US Food and Drug Administration (US FDA) approved the ranibizumab 0.3 mg prefilled syringe (PFS), and in October 2016, the US FDA approved the ranibizumab 0.5 mg PFS. This article discusses the advantages of the PFS, including reduced injection time, possible reduced risk of endophthalmitis, reduction in intraocular air bubbles and silicone oil droplets, and improved precision in the volume and dose of intravitreal ranibizumab administered, along with possible disadvantages. Implications of the innovation of the PFS on intravitreal injection technique and clinical practice pattern are discussed and reviewed.

show abstract

Accuracy and Precision of Intravitreally Injected Ranibizumab Doses: An Experimental Study

Cited by 11 publications

References 6 publications

Sicherheit, Effektivität und protektive Wirkung einer Parazentese bei intravitrealen Injektionen: „Eine Lanze für die Parazentese brechen“

Sicherheit, Effektivität und protektive Wirkung einer Parazentese bei intravitrealen Injektionen: „Eine Lanze für die Parazentese brechen“

A Novel Method for the Measurement of Reflux from Intravitreal Injections: Data from 20 Porcine Eyes

<p>Prefilled syringes for intravitreal drug delivery</p>

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