Accuracy of 18F-FDG PET/CT for Diagnosing Inguinal Lymph Node Involvement in Penile Squamous Cell Carcinoma

Sadeghi, Ramin; Gholami, Hasan; Zakavi, Seyed Rasoul; Kakhki, Vahid Reza Dabbagh; Horenblas, Simon

doi:10.1097/rlu.0b013e318238f6ea

Cited by 99 publications

(35 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent pooled-analysis has shown that PET/CT has low sensitivity in cN0 patients for detection of regional lymph node involvement in penile cancer patients. However, patients with clinically palpable lymph node may benefit from PET/CT since the sensitivity in this subgroup of patients is high [16]. The results of our study are concordant here.…”

Section: Discussionsupporting

confidence: 87%

Clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in penile cancer

Zhang

Liang

2016

Oncotarget

View full text Add to dashboard Cite

PurposeThis study investigated the value of Fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging in the management of patients with advanced penile cancer.Patients and MethodsBetween January 2009 and August 2012, 48 patients with penile cancer at our center underwent FDG-PET/CT after CT (n=39) or magnetic resonance imaging (MRI; n=9). The accuracy of FDG-PET/CT was assessed with both organ-based and patient-based analyses. FDG-PET/CT findings were validated by either biopsy or serial CT/MRI. Clinician questionnaires performed before and after FDG-PET/CT evaluated whether the scan results affected management.ResultsOne hundred fifteen individual lesions were evaluable in 42 patients for the organ-based analysis. Overall sensitivity was 85% and specificity was 86%. In the patient-based analysis, overall sensitivity and specificity were 82% and 93%, respectively. Pre- and post-PET surveys showed that FDG-PET/CT detected more malignant diseases than CT/MRI in 33% patients. Planned treatments were changed in 57% patients after FDG-PET/CT scan.ConclusionFDG-PET/CT has good sensitivity and specificity in the detection of metastatic penile cancer. It provides more diagnostic information to enhance clinical management than CT/MRI.

show abstract

Section: Discussionsupporting

confidence: 87%

Clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in penile cancer

Zhang

Liang

2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis reported that this last technique had a pooled sensitivity of 96.4% for cN+ disease and 56.5% for cN0 disease. 13 MRI with lymphotrophic nanoparticles using intravenous ferumoxtran-10 showed promising results in detecting occult metastases in a case series of seven patients with penile carcinoma. 14 However, use of these nanoparticles is currently not authorised in Europe.…”

Section: How Is Penile Cancer Investigated?mentioning

confidence: 99%

Malignant and premalignant lesions of the penis

Arya

Kalsi

Kelly

et al. 2013

BMJ

View full text Add to dashboard Cite

“…A meta‐analysis by Sadeghi et al. in 2012 showed a pooled sensitivity of 96.4% for cN+ and 56.5% for cN0 patients. Therefore, in cN+ cases, FDG PET/CT may be of diagnostic use, but its true value is yet to be determined.…”

Section: Penile Cancermentioning

confidence: 99%