Clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in penile cancer

Zhang, Sheng; Li, Wenfeng; Liang, Fei

doi:10.18632/oncotarget.9375

Cited by 27 publications

(19 citation statements)

References 15 publications

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“…The performance is better if palpably enlarged inguinal lymph nodes are present. [ 95 ] However, the evidence is insufficient and is not recommended by NCCN or ESMO as of now.…”

Section: Penile Cancermentioning

confidence: 99%

PET-CT and PET-MR in urological cancers other than prostate cancer: An update on state of the art

2018

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Hybrid positron emission tomography with computed tomography (PET/CT) and magnetic resonance imaging (PET/MRI) have enabled the combination of morphologic and functional imaging with the promise of providing better information in guiding therapy. Further advance has been made in the past decade with the development of newer radiotracers and optimization of the technical aspects. We performed a search in PubMed, Scopus, and Google Scholar for peer-reviewed literature concerning the advances and newer developments in the imaging of nonprostate urologic cancers between 2005 and 2017. This review aims at summarizing the current evidence on PET imaging in nonprostate urologic cancers and their impact on the diagnosis, staging, prognostication, response assessment, and restaging of these malignancies. However, much of the evidence is still in infancy and has not been incorporated into routine management or the practice guidelines of National Comprehensive Cancer Network or European Society for Medical Oncology (ESMO).

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“…The performance is better if palpably enlarged inguinal lymph nodes are present. [ 95 ] However, the evidence is insufficient and is not recommended by NCCN or ESMO as of now.…”

Section: Penile Cancermentioning

confidence: 99%

PET-CT and PET-MR in urological cancers other than prostate cancer: An update on state of the art

2018

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“…Graafland et al evaluated 18 patients with metastatic spread to inguinal nodes and then underwent evaluation of their pelvic nodes and found a sensitivity of 91% and specificity of 100% ( 48 ). Another study of patients with advanced disease, all of whom had inguinal disease and 21/48 (43.8%) who presented with distant metastases found 18F-FDG-PET/CT to have a sensitivity and specificity of 82% and 93%, and overall was able to detect 33% more metastatic lesions than cross-sectional imaging alone ( 49 ).…”

Section: Sln Biopsymentioning

confidence: 99%

Detection of lymph node metastases in penile cancer

Bloom

Mp²,

Patel³

et al. 2018

Transl. Androl. Urol

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Penile cancer (PC) is a relatively rare malignancy in the United States (US) but a greater concern in developing nations. Lymph node imaging remains critical to the staging and treatment of this disease as metastases develop in a predictable, anatomic fashion. Early surgical intervention remains a mainstay in treatment and imaging often aids in decision making. This review highlights the indications for imaging in both low-stage and advanced disease. Furthermore, we discuss the benefits and limitations of currently available imaging for staging of inguinal and pelvic lymph nodes in PC and novel modalities in development.

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“…In stage 3 and 4 patients, Zhang et al showed good results for lymph nodes (all locations) with a sensitivity of 93% and a specificity of 85% ( 18 ). Also in other malignancies and lymph node areas, results suggest that FDG-PET/CT has higher accuracy than CT only in staging pelvic lymph nodes ( 5 , 6 , 19 , 20 ).…”

Section: Lymph Node Stagingmentioning

confidence: 99%

“…The largest series by Zhang et al [2016] compared FDG-PET/CT to conventional CT in 42 patients with suspicious lesions on CT or MRI, leading to an implicit selection bias ( 18 ). With histopathology or follow-up imaging as a reference, sensitivity and specificity of FDG-PET/CT were 85% and 86% respectively for all metastatic sites, including lymph nodes, lung, bone, etc.…”

Section: Distant Metastasesmentioning

confidence: 99%

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The role of PET/CT imaging in penile cancer

Ottenhof¹,

Vegt²

2017

Transl. Androl. Urol.

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Positron emission tomography (PET) imaging with 18F-fluorodeoxyglucose (FDG) combined with computed tomography (CT) provides functional imaging combined with anatomic information, improving diagnostic accuracy and confidence. Although virtually all primary penile tumors are FDG-avid, PET/CT is not recommended for primary tumor staging as it has limited spatial resolution and is hampered by urinary FDG excretion. The accuracy of PET/CT for lymph node staging seems to improve with the pretest likelihood of metastatic nodes. In groins with normal physical examination, sensitivity is only 57%. In groins with palpably enlarged lymph nodes, sensitivity of PET/CT reaches 96%. For pelvic lymph nodes and distant metastases, PET/CT is more accurate if inguinal metastases are present. However, these results are based on a very limited number of studies. Overall, the role of PET/CT imaging in penile cancer remains ambiguous, especially in inguinal lymph nodes. During staging and follow-up, it may be particularly useful in detecting pelvic lymph node metastases and occult distant metastases prior to systemic chemotherapy and/or extensive surgery, improving selection of patients that are most likely to benefit from such therapies.

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Clinical value of fluorine-18 2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in penile cancer

Cited by 27 publications

References 15 publications

PET-CT and PET-MR in urological cancers other than prostate cancer: An update on state of the art

PET-CT and PET-MR in urological cancers other than prostate cancer: An update on state of the art

Detection of lymph node metastases in penile cancer

The role of PET/CT imaging in penile cancer

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