Accuracy of C-reactive protein, procalcitonin, and mid-regional pro-atrial natriuretic peptide to guide site of care of community-acquired pneumonia

Claessens, Yann-Érick; Mathevon, Thierry; Kierzek, G.; Grabar, Sophie; Jegou, David; Batard, Éric; Loyer, Clarisse; Davido, A.; Hausfater, Pierre; Robert, Hélène; Lavagna-Perez, Leila; Bernot, B.; Plaisance, Patrick; Leroy, C.; Renaud, Bertrand

doi:10.1007/s00134-010-1818-4

Cited by 46 publications

(21 citation statements)

References 49 publications

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“…On the contrary, in a study by Hohenthal et al, CRP correlated significantly with the PSI and was valuable for assessing disease severity [36]. Our results confirm previous findings that have shown that MR-proANP correlates with PSI, CURB-65, the later development of complications, and the length of hospitalization [16,37,38,44,45]. MR-proANP is involved in physiopathological changes that occur during infections, and this is one of the reasons why its levels are increased in patients with CAP.…”

Section: Discussionsupporting

confidence: 89%

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Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Lacoma

Rodríguez

Prat

et al. 2011

Eur J Clin Microbiol Infect Dis

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The aim of this study was to investigate whether procalcitonin (PCT), neopterin, C-reactive protein (CRP), and mid regional pro-atrial natriuretic peptide (MR-proANP) levels at admission and during the clinical course can be useful for the management of patients with pneumonia. The study population consisted of 75 patients with clinical and radiological diagnosis of pneumonia. Serum samples were collected at admission and during hospitalization. Complications were defined as intensive care unit (ICU) admission or death. The levels of PCT were significantly higher in pneumonia of definite bacterial origin in comparison to probable bacterial or unknown origin. The PCT levels were higher in pneumococcal pneumonia. The PCT and MR-proANP levels increased significantly according to the Pneumonia Severity Index (PSI). All biomarkers levels are higher in patients developing complications and who were dying. The serial levels of MR-proANP remain significantly elevated in patients developing complications and in patients classified in PSI and CURB-65 risk groups. In patients not developing complications, there is a significant decrease in the PCT levels. PCT can be useful for identifying pneumonia etiology. PCT and MR-proANP levels correlate with pneumonia severity rules. PCT and MR-proANP serial measurements can be useful for predicting short-term prognosis. Systemic biomarkers can provide additional information regarding clinical evolution, because these are dynamic and can be measured daily.

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Section: Discussionsupporting

confidence: 89%

“…MR-proANP is involved in physiopathological changes that occur during infections, and this is one of the reasons why its levels are increased in patients with CAP. The proposed cut-off for the prediction of complications and mortality is similar to those reported in previous studies [16,44].…”

Section: Discussionmentioning

confidence: 83%

Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Lacoma

Rodríguez

Prat

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…There is a strong correlation between MR-proANP and pneumonia clinical scores (PSI, CURB65 and CRB65) [44,45,60,61] and it predicts hospital admission better than CRB65, CRP or PCT [62]. Moreover, it is also a superior prognostic indicator for short-and long-term mortality [44,61] than clinical scores (PSI or CRB65) or other biomarkers like PCT or CRP [63,64].…”

Section: Biomarkersmentioning

confidence: 95%

Severe sepsis in community-acquired pneumonia — Early recognition and treatment

Pereira

Paiva

Rello

2012

European Journal of Internal Medicine

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“…A systematic review of 12 studies confirms that an increased MR proADM is associated with increased risk of short term mortality and that a combination of proADM and CURB-65 is associated with an improved predictive efficacy (90). A sizable Swiss study discovered that ProADM was strong predictor of TF including death with an AUC that was significantly higher than that of CRP but similar to PCT (91)(92)(93). Similarly Copeptin has been shown to be a useful marker of early mortality or ICU admission, more so than other biomarkers (89).…”

Section: Novel Biomarkersmentioning

confidence: 89%

Predictors of treatment failure and clinical stability in patients with community acquired pneumonia

Morley¹,

Torres²,

Cillóniz³

et al. 2017

Ann. Transl. Med.

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Community acquired pneumonia (CAP) is the leading infectious cause of mortality worldwide with approximately 10% of patients hospitalized requiring intensive care unit (ICU) admission. The ability to predict clinical stability (CS) and treatment failure (TF) enables the clinician to alter antibiotics appropriately, facilitate a timely ICU admission, or arrange a suitable discharge. The detection of CS and TF can be difficult and changes in clinical signs may be subtle or delayed. Thus clinical scores and biomarkers are routinely used to identify severity and monitor clinical progression. The evidence, however, is vast and the definitive role of these systems is at times difficult to elucidate. The aim of this review is to analyse the current literature and to provide a rational and clinically focused view of the predictive utility of various systems used to identify CS and TF in CAP.

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Accuracy of C-reactive protein, procalcitonin, and mid-regional pro-atrial natriuretic peptide to guide site of care of community-acquired pneumonia

Abstract: In a selected population of CAP with low risk of complication, a single ANP measurement was more accurate than CRP and PCT to predict appropriate admission. These results should be confirmed by additional studies.

Cited by 46 publications

References 49 publications

Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Usefulness of consecutive biomarkers measurement in the management of community-acquired pneumonia

Severe sepsis in community-acquired pneumonia — Early recognition and treatment

Predictors of treatment failure and clinical stability in patients with community acquired pneumonia

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