Accuracy of cerebrospinal fluid ferritin for purulent meningitis

García, Pedro Celiny Ramos; Barcelos, Andrea Lucia Machado; Tonial, Cristian Tedesco; Fiori, Humberto Holmer; Einloft, Paulo Roberto; Costa, Caroline Abud Drumond; Portela, J.L.; Bruno, Francisco; Branco, Ricardo Garcia

doi:10.1136/archdischild-2019-317960

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…The gold standard test for detecting BM is CSF bacterial culture[ 12 ]. Nonetheless, this method has limitations, including low sensitivity and delayed microbial growth, affecting clinical decision-making.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B virus in cerebrospinal fluid of a patient with purulent bacterial meningitis detected by multiplex-PCR: A case report

Gao¹,

Hu²,

Wang³

et al. 2022

WJCC

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BACKGROUND Bacterial meningitis (BM) is a common central nervous system inflammatory disease. BM may cause serious complications, and early diagnosis is essential to improve the prognosis of affected patients. CASE SUMMARY A 37-year-old man was hospitalized with purulent meningitis because of worsening headache for 12 h, accompanied by vomiting, fever, and rhinorrhea. Head computed tomography showed a lesion in the left frontal lobe. Infectious disease screening showed positivity for hepatitis B surface antigen, hepatitis B e antigen, and hepatitis B core antigen. Cerebrospinal fluid (CSF) leak was suspected based on clinical history. Streptococcus pneumoniae ( S. pneumoniae ) was detected in CSF by metagenomic next-generation sequencing (mNGS) technology, confirming the diagnosis of purulent BM. After treatment, multiplex PCR indicated the presence of hepatitis B virus (HBV) DNA and absence of S. pneumoniae DNA in CSF samples. CONCLUSION We report a rare case of HBV in the CSF of a patient with purulent BM. Multiplex PCR is more sensitive than mNGS for detecting HBV DNA.

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Section: Introductionmentioning

confidence: 99%

Hepatitis B virus in cerebrospinal fluid of a patient with purulent bacterial meningitis detected by multiplex-PCR: A case report

Gao¹,

Hu²,

Wang³

et al. 2022

WJCC

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Immunologic biomarkers for bacterial meningitis

Yekani

Memar

2023

Clinica Chimica Acta

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External ventricular drainage following purulent meningitis with hydrocephalus in pediatric patients

Sun,

Xiao,

Luo

et al. 2024

Preprint

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Background External ventricular drain (EVD) placement is standard of care in the management of purulent meningitis with hydrocephalus (PMH). However, there are no guidelines for EVD placement and management after PMH. Optimal EVD insertion location, techniques to reduce the risk of EVD-associated infection and methods of EVD removal are critical, yet incompletely answered management variables. Methods The indwelling time of conventional external ventricular drainage is relatively short, 7–10 days. Long-term external drainage devices may lead to retrograde infection. This study has modified the C-EVD procedure. Clinical outcomes, cerebrospinal fluid (CSF) test results, complications, and outcomes were compared between the modified external ventricular drainage (M-EVD) (n = 21) group and C-EVD (n = 25) group. Results The two groups were similar regarding age, sex, weight and other general conditions (P > 0.05). There were significant differences in the values of white blood cells (WBC), glucose(GLU) and protein(PR) in cerebrospinal fluid (CSF) between the two groups when the drainage tube was removed, which was statistically significant. The median days of removing the drainage tube in the C-EVD group and the M-EVD group were 9 days and 19 days, respectively. The median days of CSF returning to normal were 19 days and 13 days (P < 0.05). A total of 13 children in the M-EVD group underwent V-P shunt surgery, while 17 children in the C-EVD group were treated with V-P shunt surgery (P = 0.665). Conclusion M-EVD has more obvious advantages compared to C-EVD. The modified significantly prolonged the catheterization time, which can more effectively treat PMH in pediatric patients.

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Accuracy of cerebrospinal fluid ferritin for purulent meningitis

Cited by 3 publications

References 9 publications

Hepatitis B virus in cerebrospinal fluid of a patient with purulent bacterial meningitis detected by multiplex-PCR: A case report

Hepatitis B virus in cerebrospinal fluid of a patient with purulent bacterial meningitis detected by multiplex-PCR: A case report

Immunologic biomarkers for bacterial meningitis

External ventricular drainage following purulent meningitis with hydrocephalus in pediatric patients

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