“…Implementations have drawn on various algorithms, including knowledge-based, model-based and machine learning-based approaches. (Codari, Caffini, Tartaglia, Sforza, & Baselli, 2017;Gupta, Kharbanda, Sardana, Balachandran, & Sardana, 2015;Makram & Kamel, 2014;Montufar, Romero, & Scougall-Vilchis, 2018;Shahidi, Oshagh, Gozin, Salehi, & Danaei, 2013) The knowledge-or model-based approaches were initially adopted due to their ease of development. However, their high ambiguity in identifying complex craniofacial structure hindered wider application.…”