Accuracy of family history of cancer obtained through interviews with relatives of patients with childhood sarcoma

Bondy, Melissa L.; Strom, Sara S.; Colopy, Michael W.; Brown, Barry W.; Strong, Louise C.

doi:10.1016/0895-4356(94)90037-x

Cited by 72 publications

(46 citation statements)

References 10 publications

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“…However, it has been observed previously that the accuracy of reporting cancers in first-degree relatives generally is high. 23,24 For example, Love et al 23 reported that 83% of primary cancer sites of first-degree relatives were identified correctly by probands. For bladder cancer, the overall accuracy was 70%.…”

Section: Discussionmentioning

confidence: 99%

Bladder cancer risk as modified by family history and smoking

Lin

Spitz

Dinney

et al. 2006

Cancer

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This study investigated the ability of MnCl2 as a cellular MRI contrast agent to determine the in vitro viability of human embryonic stem cells (hESC) and human bone marrow stromal cells (hBMSC). Basic MRI parameters including T1 and T2 values of MnCl2‐labeled hESC and hBMSC were measured and viability signal of manganese (Mn2+)‐labeled cells was validated. Furthermore, the biological activity of Ca2+‐channels was modulated utilizing both Ca2+‐channel agonist and antagonist to evaluate concomitant signal changes. Metabolic effects of MnCl2‐labeling were also assessed using assays for cell viability, proliferation, and apoptosis. Finally, in vivo Mn2+‐guided MRI of the transplanted hESC was successfully achieved and validated by bioluminescence imaging. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Bladder cancer risk as modified by family history and smoking

Lin

Spitz

Dinney

et al. 2006

Cancer

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“…Adults with cancer have been shown to report their family history of cancer in first degree relatives quite accurately. [25][26][27][28][29][30][31][32][33] Bondy et al studied the accuracy of data on family history of cancer obtained by interviewing the mothers of children and adolescents with sarcoma 34 and reported positive predictive values (PPV) of 88 and 71% for first-and second-degree relatives of children, respectively. For Perillat et al, 17 the PPV of mothers' reports on first-degree relatives of children with leukemia was 100%.…”

Section: Discussionmentioning

confidence: 99%

Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non‐Hodgkin's lymphoma: The ESCALE study (SFCE)

Rudant

Ménégaux

Leverger

et al. 2007

Intl Journal of Cancer

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The role of a family history of cancer in the etiology of childhood hematopoietic malignancies was investigated using the data from the ESCALE study. ESCALE, a population‐based case–control study, was carried out in France over the period, 2003–2004. A total of 773 cases of acute leukemia (AL), 130 of Hodgkin's lymphoma (HL), 163 of non‐Hodgkin's lymphoma (NHL) and 1,681 population‐based controls were included. The controls were randomly selected from the French population and were frequency matched with the cases on age and gender. Cancer history in first‐ and second‐degree relatives was reported by the mothers in a structured telephone questionnaire that was the same for the cases and controls. Odds ratios (ORs) were estimated using an unconditional regression model taking into account the stratification variables and potential confounders. A family history of cancer was associated with an increased risk of HL (OR = 1.5 [1.0–2.2]) and NHL (OR = 1.8 [1.3–2.5]), but not AL (OR = 1.0 [0.9–1.2]). The ORs were higher when at least 2 relatives had a history of cancer or when 1 case occurred before age 46 years. Only HL was significantly associated with a family history of hematopoietic malignancies (OR = 2.0 [1.0–3.8]), mainly because of a significant association with a history of HL (OR = 5.4 [1.3–22]). In conclusion, the study findings support the hypothesis of familial susceptibility to childhood lymphoma, but do not suggest familial susceptibility to childhood AL. © 2007 Wiley‐Liss, Inc.

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“…However, nondifferential misclassification of familial cancer would usually lead to an underestimation of the true risk and would therefore not explain the risk elevation noted. Studies have validated patient report of family history by medical records 51 or through comparison with expected numbers of cancers based on population incidence. 52 Bondy et al 51 have shown that subjects correctly identified the primary site of cancer for 88% of cases in first-degree relatives and for lung cancer in 85%.…”

Section: Limitations Of the Studymentioning

confidence: 99%

“…Studies have validated patient report of family history by medical records 51 or through comparison with expected numbers of cancers based on population incidence. 52 Bondy et al 51 have shown that subjects correctly identified the primary site of cancer for 88% of cases in first-degree relatives and for lung cancer in 85%. Pinsky et al 52 observed that the ratio of reported to expected number of cancers in family members was about 0.7 (30% underreporting), with female probands tending to underreport less often than male probands.…”

Section: Limitations Of the Studymentioning

confidence: 99%

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Gorlova

Weng

Zhang

et al. 2007

Intl Journal of Cancer

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The authors evaluated the familial aggregation of lung and other cancers in first-degree relatives of lung cancer patients selfreported to be lifetime never smokers. The data, derived from a large lung cancer case-control study, included 2,465 first-degree relatives of 316 never smoker lung cancer cases and 2,441 firstdegree relatives of 318 never smoker controls, frequency matched to the cases on age, gender and ethnicity. The median age of the cases and the controls was 61 years, about 2/3 were women, and about 80% were Caucasian. Overall, there was a 25% excess risk [95% CI (1.05-1.50)] of any type of cancer among the first-degree relatives of cases, and case offspring exhibited a 2-fold excess cancer risk (1.03-4.10) compared with control offspring. There was also a 44% excess risk ( Key words: lung cancer; familial aggregation; never smokers Lifetime never smokers with lung cancer likely represent a genetically susceptible subgroup distinct from ever smokers with lung cancer. 1 Familial aggregation may provide indirect evidence for a role of genetic factors in lung cancer susceptibility. The majority of studies that have evaluated familial aggregation in never-smoking lung cancer patients reported increased but not statistically significant lung cancer risk. [2][3][4][5][6][7][8][9] Several recent studies that analyzed aggregation of lung cancer in relatives of lung cancer patients reported no increased risk in first-degree relatives of never-smoking lung cancer cases. 8,9 However, one study suggested a significant 6-fold increased lung cancer risk in relatives of younger (40-59 years old) nonsmoking lung cancer patients, yet based on a small number of individuals (47 lung cancer cases and 50 controls). 3 Only a few studies have evaluated occurrence of other specific cancers in relatives of never-smoking lung cancer patients. 7,10,11 We estimated the risk of lung cancer and other cancers in firstdegree relatives of never-smoking lung cancer cases compared with first-degree relatives of matched controls, using self-reported data on family history derived from an ongoing lung cancer casecontrol study, controlling for relatives' smoking status as reported by the proband. Material and methods Subject recruitmentFrom September 1995 through December 2003, patients with lung cancer were accrued for an ongoing and previously described molecular epidemiological study on susceptibility markers for lung cancer from The University of Texas M. D. Anderson Cancer Center. 8,12,13 There were no age, gender, ethnic or stage restrictions. There were 316 patients with histologically confirmed lung cancer, who reported themselves to be lifetime never smokers (defined as those who had smoked less than 100 cigarettes in their lifetime). The response rate for cases was about 80%. The reasons for refusal to participate included patient too ill, patient referred only for second opinion to M. D. Anderson Cancer Center or patient unwilling to donate blood for the study and complete the interview. Healthy controls who were also lifeti...

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Accuracy of family history of cancer obtained through interviews with relatives of patients with childhood sarcoma

Cited by 72 publications

References 10 publications

Bladder cancer risk as modified by family history and smoking

Bladder cancer risk as modified by family history and smoking

Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non‐Hodgkin's lymphoma: The ESCALE study (SFCE)

Aggregation of cancer among relatives of never‐smoking lung cancer patients

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