Accuracy of frozen section examination of pelvic lymph nodes in patients with FIGO stage IB1 to IIB cervical cancer

Scholz, Heinz S.; Lax, Sigurd; Benedicic, Christoph; Tamussino, Karl; Winter, Raimund

doi:10.1016/s0090-8258(03)00398-6

Cited by 34 publications

(13 citation statements)

References 17 publications

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“…Die intraoperative Schnellschnittuntersuchung der pelvinen Lymphknoten hat eine Vorhersagekraft von 84 % für Metastasen und korreliert mit der Lymphknotengröße, ist aber zeitlich aufwendig und ressourcenintensiv [41]. Wesentliche Prädiktoren für die Lymphknotenmetastasen sind das FIGO-Stadium, das Tumorvolumen und das Vorhandensein von LSVI.…”

Section: Therapeutische Strategieunclassified

Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen

Lax¹,

Tamussino

Lang³

2016

Pathologe

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Section: Therapeutische Strategieunclassified

Metastasierung von Malignomen des Uterus und therapeutische Konsequenzen

Lax¹,

Tamussino

Lang³

2016

Pathologe

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“…Hence, combinations including SLN status appeared less relevant due to the low accuracy of imprint cytology to detect lymph node involvement. Previous studies have underlined the contribution of intra-operative histology based on frozen section but this is associated with loss of tissue sample for definitive histology (13,(25)(26)(27). The sensitivity, NPV and FN rates of frozen section reported by Panici et al were 90, 97, and 4.2%, respectively (13).…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

“…The sensitivity, NPV and FN rates of frozen section reported by Panici et al were 90, 97, and 4.2%, respectively (13). In various series, FN rates ranged from 4.2 to 32% (13,(25)(26)(27). To improve the accuracy of intra-operative histology, several biological techniques based on RT-PCR have been proposed using both cytokeratin 19 and human papillomavirus but were not able to differentiate between types of metastases (15,28).…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Clues pointing to simple hysterectomy to treat early-stage cervical cancer

Coutant

Cordier²,

Guillo³

et al. 2009

Oncol Rep

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Abstract. Radical hysterectomy and pelvic lymphadenectomy is recommended for stage Ia2-Ib1 cervical cancer while parametrial involvement (PI) is rare. Our aim was to evaluate criteria to select women with low risk of PI that could benefit from simple hysterectomy. Factors associated with low risk of PI were analyzed in a series of 37 patients with stage Ia2-Ib1 cervical cancer undergoing radical hysterectomy and sentinel lymph node procedure from 2003 to 2008. PI was associated with tumor size (p<0.001) and lymphovascular space invasion (LVSI) (p=0.007). PI was found in 4.5% of patients with tumor size ≤2 cm versus 33% with tumor size >2 cm (p=0.04). The negative predictive value was 100% for absence of LVSI (95% CI: 0.83-1) and for combinations: tumor size ≤2 cm and SN negative (95% CI: 1-1), tumor size ≤2 cm and no LVSI (95% CI: 0.86-1), tumor size ≤2 cm and tumor grade 1-2 and no LVSI (95% CI: 0.82-1), and tumor size ≤2 cm and PLN negative and no LVSI (95% CI: 0.83-1). Among various combinations, a tumor size ≤2 cm and absence of LVSI appears the most relevant to predict parametrial status.

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“…Même en cas d'utilisation de coupes congelées, les différentes études rapportent des taux de faux-négatifs variant de 4,2 à 32 % [27][28][29][30].…”

Section: Apport Du Ganglion Sentinelleunclassified