Accuracy of intraoperative frozen section in the diagnosis of ovarian tumors

Yarandi, Fariba; Eftekhar, Zahra; Izadi-Mood, Narges; Shojaei, Hadi

doi:10.1111/j.1479-828x.2008.00873.x

Cited by 30 publications

(23 citation statements)

References 11 publications

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“…The pathologist of other sections may not be familiar with diagnostic clues and FS may become difficult. In spite of these disadvantages overall diagnostic accuracy of FS was reported to be reliable in large series ranging from 84.25% to 97.1%, which was 96.5% in our study (1,(3)(4)(5)(6)(7). We think that attendance of the gynecopathologist to gross examination is a very important factor to increase the diagnostic accuracy of FS.…”

Section: Discussionmentioning

confidence: 74%

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Acikalin

Torun²,

Bağır³

et al. 2014

TJPATH

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Objective: Frozen section is an accurate diagnostic tool with some unavoidable pitfalls in gynecologic tumors. We aimed to evaluate the diagnostic value of frozen section, and to detect the factors causing erroneous diagnosis in ovarian tumors. Material and Method:Frozen section and paraffin section reports of 282 patients with ovarian neoplasms diagnosed between July 2006 and January 2013 in our institute were re-analyzed. Results were grouped into benign, borderline (for epithelial tumors) and malignant categories and compared between frozen section and paraffin section diagnosis, statistically. Results:Overall diagnostic accuracy of frozen section was 96.5%. Sensitivity of frozen section for benign, borderline and malignant tumors were 97.5%, 95.8%, and 95.6% and the related specificities were 97.5%, 97.6%, and 100%, respectively. We found the lowest positive predictive value in borderline group (79.3%), all of them with mucinous type epithelium. Second frequent discordant tumor type was immature teratoma. Conclusion:Apart from the limitations of frozen section, pathologists should be aware of the pitfalls of technique and tumor types and tend to sample from the solid areas particularly in mucinous tumors and teratomas to avoid inappropriate surgery. Bulgular:Frozen incelemenin genel tanısal doğruluk oranı %96,5 idi. Benign, borderline ve malign tümörler için frozen incelemenin duyarlığı sırasıyla %97,5, %95,8 ve %95,6 idi. Özgüllük ise aynı sırayla, %97,5, %97,6 ve %100 idi. En düşük pozitif prediktif değer borderline grubunda saptandı (%79,3) ve hataya neden olan tüm olgular müsinöz tip epitelyal tümörler idi. Tanı uyumsuzluğu bulunan ikinci tümör grubu ise immatür teratom idi. Sonuç:Frozen incelemenin kısıtlılıkları yanısıra, patoloğun frozen incelemenin teknik veya tümör tipi ile ilgili tuzaklarını bilmesi, özel-likle müsinöz tümörler ve teratom olgularında solid görünen alanlardan örneklenmesi yetersiz veya gereksiz operasyon yapılmasını önlemek adına yararlı olacaktır.

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Section: Discussionmentioning

confidence: 74%

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Acikalin

Torun²,

Bağır³

et al. 2014

TJPATH

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“…According to considerable amounts of evidence, the sensitivity and specificity of frozen section examination can be as high as 92.8%-100% and 81%-98% for benign ovarian tumors and 87%-100% and 99%-100% for malignant ovarian tumors, respectively. However, the sensitivity and specificity for borderline ovarian tumors can be as low as 33.3%-78.3% and 92%-97%, respectively (14,15). Unfortunately, the diagnostic accuracy based on frozen section examination for ovarian leiomyomas remains unknown due to the rarity of these tumors.…”

Section: Discussionmentioning

confidence: 92%

Ovarian leiomyoma as a potential cause of compromised fertility

Koo

Cho

Kim

et al. 2011

Fertility and Sterility

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“…Some authors have suggested that under diagnosis was due to sampling errors and they advised using greater number of frozen sections to minimize the under diagnosis of tumors, recommending one section per 10cms of mass. some recent studies have indicated that after sampling errors, the absence of an expert pathologist is responsible for the misdiagnosis of tumors [19,20,21] . In addition pathologists should be informed about tumor status, peritoneal implants and the contra lateral ovary.…”

Section: Discussionmentioning

confidence: 99%

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

Maheshwari¹

2017

jmscr

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Accuracy of intraoperative frozen section in the diagnosis of ovarian tumors

Abstract: Frozen section appears to be an accurate technique for the histopathological diagnosis of ovarian tumours. Some limitations were observed among borderline and mucinous tumours. This emphasises the great value of frozen section in the diagnosis of ovarian tumours.

Cited by 30 publications

References 11 publications

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Intraoperative frozen section in ovarian neoplasms; a tertiary center experience

Ovarian leiomyoma as a potential cause of compromised fertility

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

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