Accuracy of Liver Fat Quantification at MR Imaging: Comparison of Out-of-Phase Gradient-Echo and Fat-saturated Fast Spin-Echo Techniques—Initial Experience

Qayyum, Aliya; Goh, Jeffrey Seow Kuang; Kakar, Sanjay; Yeh, Benjamin M.; Merriman, Raphael B.; Coakley, Fergus V.

doi:10.1148/radiol.2372040539

Cited by 168 publications

(155 citation statements)

References 20 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…In subjects with cirrhosis, only the ϮFS imaging was correlated with the histopathology. Variable hepatic iron levels (particularly in cirrhotic patients), which affect the relaxation constants, were discussed as a potential reason for the lower correlation of phase-edited MRI with liver biopsy results (29). This is consistent with the single subject in our study with elevated hepatic iron levels that gave large negative values for phase-edited IHCL.…”

Section: Discussionsupporting

confidence: 89%

“…A strong correlation between IP/OP imaging with histology (27) and MRS (28) has also been reported. Qayyum et al (29) investigated a group of subjects with and without cirrhosis by phase-edited and FS-edited imaging using the spleen as an internal standard on a GE system. They reported that ϮFS imaging was better correlated with histopathology than in-opposite phase imaging in noncirrhotic subjects (29).…”

Section: Discussionmentioning

confidence: 99%

“…Qayyum et al (29) investigated a group of subjects with and without cirrhosis by phase-edited and FS-edited imaging using the spleen as an internal standard on a GE system. They reported that ϮFS imaging was better correlated with histopathology than in-opposite phase imaging in noncirrhotic subjects (29). In subjects with cirrhosis, only the ϮFS imaging was correlated with the histopathology.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

Cowin

Jonsson

Bauer

et al. 2008

Magnetic Resonance Imaging

177

142

View full text Add to dashboard Cite

Purpose:To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content. Materials and Methods:Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using inphase/out-of-phase (IP/OP) and plus/minus fat saturation (ϮFS) techniques. The reproducibility of each MR measure was also determined. An additional group of overweight patients with steatosis underwent hepatic MRI and MRS before and after a six-month weight-loss program. Results:A close correlation was demonstrated between histological assessment of steatosis and measurement of intrahepatocellular lipid (IHCL) by MRS (r s ϭ 0.928, P Ͻ 0.0001) and MRI (IP/OP r s ϭ 0.942, P Ͻ 0.0001; FS r s ϭ 0.935, P Ͻ 0.0001). Following weight reduction, four of five patients with Ͼ5% weight loss had a decrease in IHCL of Ն50%. Conclusion:These findings suggest that standard MRI protocols provide a rapid, safe, and quantitative assessment of hepatic steatosis. This is important because MRS is not available on all clinical MRI systems. This will enable noninvasive monitoring of the effects of interventions such as weight loss or pharmacotherapy in patients with fatty liver diseases.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

Cowin

Jonsson

Bauer

et al. 2008

Magnetic Resonance Imaging

177

142

View full text Add to dashboard Cite

show abstract

“…Also, the authors could not determine the results for patients with hepatic steatosis, since these patients were not included in the present sample. This variable should still be evaluated, considering that hepatic steatosis may affect the hepatic parenchyma signal intensity on T2-weighted images with fat-suppression (SPIR), like those utilized in the present study (16) . The evaluation of an objective parameter, for example, the nodule/liver signal ratio could add subsidiary results for the differentiation between cysts and hemangiomas on the different sequences utilized and this is a reason for continuing the present study whose results should be reported in a near future.…”

Section: Discussionmentioning

confidence: 99%

Diferenciação entre cisto simples e hemangioma hepático utilizando seqüência de ressonância magnética ponderada em T2 com técnica gradiente-eco (B-FFE)

et al. 2008

View full text Add to dashboard Cite

OBJECTIVE: To establish the role of MRI T2-weighted sequences in the differentiation between simple cysts and hepatic hemangiomas. MATERIALS AND METHODS: A double-blinded, prospective, observational, crosssectional study evaluated 52 patients with 91 hepatic lesions (34 simple cysts and 57 hemangiomas) submitted to abdominal magnetic resonance imaging. The combined analysis of all sequences was considered as the golden-standard. TSE sequences with long echo trains and b-FFE sequences were subjectively analyzed by two independent observers for differentiating cysts from hemangiomas. The kappa test (κ κ κ κ κ) was utilized in the analysis of the methods accuracy and inter-and intra-observer agreement ( p < 0.05*). RESULTS: Cysts and hemangiomas dimensions ranged respectively between 0.5 and 6.5 cm (mean = 1.89 cm), and 0. OBJETIVO: Estabelecer o valor das seqüências ponderadas em T2 para diferenciar cistos simples de hemangiomas hepáticos. MATERIAIS E MÉTODOS: Estudo prospectivo, observacional, transversal e duplo-cego em 52 pacientes com 91 lesões hepáticas (34 cistos simples e 57 hemangiomas) submetidos a ressonância magnética de abdome. A análise conjunta de todas as seqüências realizadas foi considerada o padrão-ouro. Dois observadores independentes avaliaram, subjetivamente, as seqüências TSE com TE longo e B-FFE, procurando diferenciar cistos de hemangiomas. Foram calculadas a eficácia das seqüências e a concordân-cia interobservador e intra-observador por meio do teste kappa (κ κ κ κ κ) (p < 0,05*). RESULTADOS: As dimensões dos cistos variaram entre 0,5 e 6,5 cm (média de 1,89 cm) e as dos hemangiomas, entre 0,8 e 11 cm (média de 2,62 cm). A concordância entre a avaliação da seqüência com TE longo e o padrão-ouro foi insignificante (κ κ κ κ κ: 0,00-0,10). A concordância entre a avaliação da seqüência B-FFE e o padrão-ouro variou de substancial (κ κ κ κ κ: 0,62-0,71) a quase perfeita (κ κ κ κ κ: 0,86) para ambos os examinadores. A concordância interobservador e intra-observador para a seqüência B-FFE variou entre substancial (κ κ κ κ κ: 0,62-0,70) e quase perfeita (κ κ κ κ κ: 0,85-0,91). CONCLUSÃO: A técnica B-FFE apresenta eficácia e reprodutibilidade elevadas na diferenciação de cistos e hemangiomas. Unitermos: Fígado; Cisto; Hemangioma; Imagem por ressonância magnética. AbstractResumo

show abstract

“…A limitation of liver biopsy is its sampling variability (Ratziu et al 2009;Qayyum et al 2005). Sampling variability is a relevant limitation of liver biopsy due to the fact that the liver biopsy specimen represent only a very limited part of the whole liver and that histologic lesions of NAFLD/NASH are likely to have a very unevenly distribution in the liver ), even at a macroscopic level.…”

Section: Sampling Variabilitymentioning

confidence: 99%

Metabolic Steatosis & Fibrosis: Review of the Non-Invasive Tools for Diagnosis and Screening

Miette¹,

Abdennour²,

Sandrin³

et al. 2011

Liver Biopsy in Modern Medicine

View full text Add to dashboard Cite

Accuracy of Liver Fat Quantification at MR Imaging: Comparison of Out-of-Phase Gradient-Echo and Fat-saturated Fast Spin-Echo Techniques—Initial Experience

Abstract: Preliminary results suggest liver fat may be more accurately quantified with fat-saturated fast spin-echo MR imaging than with out-of-phase gradient-echo MR imaging, especially in patients with cirrhosis.

Cited by 168 publications

References 20 publications

Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

Diferenciação entre cisto simples e hemangioma hepático utilizando seqüência de ressonância magnética ponderada em T2 com técnica gradiente-eco (B-FFE)

Metabolic Steatosis & Fibrosis: Review of the Non-Invasive Tools for Diagnosis and Screening

Contact Info

Product

Resources

About