Accuracy of point‐of‐care‐testing (POCT) for determining hemoglobin concentrations

Gehring, Hartmut; Hornberger, Ch.; Dibbelt, L.; Rothsigkeit, A; Gerlach, Kerstin; Schumacher, Justin; Schmucker, P.

doi:10.1034/j.1399-6576.2002.460809.x

Cited by 90 publications

(49 citation statements)

References 17 publications

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“…The standard for assessing the accuracy of the Hb measurement using POCT varies based on its clinical usage; it ranges from 0.5 g/dl for a perioperative blood transfusion [14] to 1.0 g/dl in various other settings [6,15]. As such, a mean difference of 1.27 g/dl for capillary and 0.91 g/dl for venous samples using Mission® Plus Hb as compared to the standard reference is considered good.…”

Section: Discussionmentioning

confidence: 99%

Validity of Point-of-Care Testing with Mission Plus Hemoglobin in Detecting Anemia

Ahmad¹,

Awaluddin²,

Samad³

et al. 2015

Int J Biomed

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Background: Point-of-care testing, POCT, was widely used to assess hemoglobin status before proceeding with the confirmation test. Our study aimed to assess the validity of Mission® Plus Hb in detecting hemoglobin levels in a general population compared with a standard laboratory hematology analyser as the gold standard.Methods: Two types of samples, capillary and venous blood, were collected from all respondents by trained nurses. Both blood samples were tested using Mission® Plus while the remaining venous blood in EDTA test tubes was sent to the reference laboratory.Results: A total of 622 respondents participated in this study, 75% of them females. The mean Hb tested from capillary blood using Mission® Plus Hb was 11.80±2.02 g/dl. For venous blood, the mean Hb concentrations using Mission® Plus Hb and Sysmex XE-2100 hematology analyser were 12.16±1.84 g/dl and 13.07±1.87 g/dl, respectively. Sensitivity and specificity in detecting anemia from venous samples were 98.8% and 73.4% respectively. Positive Predictive Value (PPV) was 58.5%, while Negative Predictive Value (NPV) was 99.4%. Conclusion:The findings of moderate PPV should alert the programme managers to the importance of a confirmatory test following screening using Mission® Plus Hb.

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Section: Discussionmentioning

confidence: 99%

Validity of Point-of-Care Testing with Mission Plus Hemoglobin in Detecting Anemia

Ahmad¹,

Awaluddin²,

Samad³

et al. 2015

Int J Biomed

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“…The use of wet heparinized samples is well known to influence scattering of the result, 5 and might have influenced our reference values that were obtained with tubes containing liquid K 3 -EDTA. As the laboratory samples were also only measured once from one sample, this could have led to more variability than reported for the reference method and therefore an increased standard deviation and LOA of the mean bias.…”

Section: Discussionmentioning

confidence: 99%

“…It was proposed that the limits of agreement (LOA) should lie within +5 g/L to detect if anaemia is present or transfusion therapy is effective. 5,37 The limits of the HemoCue LOA are a bit wider than required but nevertheless are still classified as adequate accuracy. 5 However, the i-STAT bias and LOA are far from being accurate, not only in our study but also in most other veterinary studies.…”

Section: Discussionmentioning

confidence: 99%

“…5,37 The limits of the HemoCue LOA are a bit wider than required but nevertheless are still classified as adequate accuracy. 5 However, the i-STAT bias and LOA are far from being accurate, not only in our study but also in most other veterinary studies. 14 -16,19 -21 Another way to define if a POCT is distinguishing pathological samples from normal ones is to calculate the sensitivity and the specificity of the method to detect Table 2 Results of intra-assay precision analysis of haemoglobin (Hb) in two samples of porcine blood…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of two devices for point-of-care testing of haemoglobin in neonatal pigs

et al. 2012

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In veterinary medicine, point-of-care testing (POCT) techniques have become popular, since they provide immediate results and only small amounts of blood are needed. However, their accuracy is controversial. Pigs are often used for research purposes and accurate measurement of haemoglobin (Hb) is important during invasive procedures. The aim of this study was to evaluate two different Hb POCT devices in neonatal pigs. A prospective study with 57 pigs of 3-6 weeks of age, weighing 4.1 -6.2 kg (median 5.1 kg) was performed. Fifty-seven blood samples were analysed for Hb using a conductivitybased and a photometrical POCT device and compared with a photometrical reference method.

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“…Blood gas Arora [66] 2011 Prospective USA 516 SN, SP, PPV, NPV Bailey [67] 1998 Prospective USA 222 NR Beneteau Burnat [68] 2004 Experimental France 20 NR Beneteau Burnat [69] 2008 Experimental France NR NR Chance [70] 2000 Experimental USA NR NR Coplin [71] 1998 Prospective USA 195 SN, SP Dohgomori [72] 2004 Prospective Japan 27 NR Frasca [73] 2011 Prospective France 471 NR Gayat [74] 2001 Prospective France 200 NR Gehring [75] 2002 Experimental Germany 450 NR Grosse [76] 2010 Prospective Switzerland NR NR Halpern [77] 1998 Prospective USA NR NR Hinkelbein [78] 2008 Prospective Germany 170 NR Jacobs [79] 1993 Experimental USA 259 NR Jain [80] 2009 Cohort USA 200 NR Kilgore [81] 1998 Prospective USA NR NR Kulkani [82] 2005 Prospective Australia NR NR Leino [83] 2011 RCT Finland 60 NR Lindemans [84] 1999 Experimental Netherlands NR NR Ng [85] 2000 Experimental USA NR NR Papadea [86] 2002 Experimental USA NR NR Petersen [87] 2008 Prospective USA 114 NR Prause [88] 1997 Experimental Austria NR NR Schlebush [89] 2001 Experimental Germany NR NR Sediame [90] 1999 Experimental France 92 NR Steinfelder Visscher [91] 2006 Prospective Netherlands 127 NR Thomas [92] 2009 Cohort USA 446 NR Walton [93] 2003 Experimental USA 59 NR Wax [94] 2007 Retrospective USA NR NR Zaman [95] 2001 experimental Belgium 20 NR LR+, positive likelihood ratio; LR-, negative likelihood ratio; NPV, negative predictive value; NR, not reported; PPV, positive predictive value; PTH, parathyroid hormone SN, sensitivity; SP, specificity.…”

Section: Diagnostic Accuracy Outcomementioning

confidence: 99%

Point-of-care testing: where is the evidence? A systematic survey

Pecoraro

Germagnoli

Banfi

2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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Point-of-care testing (POCT) has had rapid techno logical development and their use is widespread in clinical laboratories to assure reduction of turn-aroundtime and rapid patient management in some clinical settings where it is important to make quick decisions. Until now the papers published about the POCT have focused on the reliability of the technology used and their analy tical accuracy. We aim to perform a systematic survey of the evidence of POCT efficacy focused on clinical outcomes, selecting POCT denoted special analytes characterized by possible high clinical impact. We searched in Medline and Embase. Two independent reviewers assessed the eligibility, extracted study details and assessed the methodological quality of studies. We analyzed 84 studies for five POCT instruments: neonatal bilirubin, procalcitonin, intra-operative parathyroid hormone, troponin and blood gas analysis. Studies were at high risk of bias. Most of the papers (50%) were studies of correlation between the results obtained by using POCT instruments and those obtained by using laboratory instruments. These data showed a satisfactory correlation between methods when similar analytical reactions were used. Only 13% of the studies evaluated the impact of POCT on clinical practice. POCT decreases the time elapsed for making decisions on patient management but the clinical outcomes have never been adequately evaluated. Our work shows that, although POCT has the potential to provide beneficial patient outcome, further studies may be required, especially for defining its real utility on clinical decision making.

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Accuracy of point‐of‐care‐testing (POCT) for determining hemoglobin concentrations

Abstract: The above-stated requirement for POCT systems, i.e. that the confidence limits should lie close to 5 g/l cHb, held true for the dry heparinized samples of the blood gas analyzer (1st measurement and mean of 2), the HemoCue system (mean of 3) and the automated hematology analyzer.

Cited by 90 publications

References 17 publications

Validity of Point-of-Care Testing with Mission Plus Hemoglobin in Detecting Anemia

Validity of Point-of-Care Testing with Mission Plus Hemoglobin in Detecting Anemia

Evaluation of two devices for point-of-care testing of haemoglobin in neonatal pigs

Point-of-care testing: where is the evidence? A systematic survey

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