-This paper reports a study undertaken to determine whether differences exist in practice between respiratory physicians, general physicians and intensivists or between individual clinicians in initiating mechanical ventilation in respiratory failure due to chronic obstructive pulmonary disease (COPD), the factors influencing decisionmaking and their relation to the evidence base. Of 725 questionnaires sent to clinicians, 350 (48%) were completed and analysed. Twenty-five variables were included which clinicians scored 0-3 according to their perceived relevance in the decision. The sum of all the responses was calculated for each clinician: respiratory 15-68, general 12-65, intensivists 16-64. The most important variables in withholding ventilation were lung cancer inoperable due to COPD, and nursing home resident. The least important variables were treated depression and osteoporosis. No significant differences existed in practice between specialties but there were great differences between individuals' practices. Clinicians were influenced by similar factors, but these did not reflect documented poor outcome predictors. Guidelines are needed.
KEY WORDS: chronic obstructive pulmonary disease (COPD), decision-making, intensive care, ventilationChronic obstructive pulmonary disease (COPD) is progressive and has substantial morbidity and mortality. Declining lung function, acute exacerbations with respiratory compromise, and deteriorating quality of life characterise its course. Patients with exacerbations requiring mechanical ventilation have a hospital mortality of 11-82%. 1-6 Survivors often do not regain their previous function. 2,5 So the wisdom of instituting invasive ventilation in such circumstances can be finely balanced.Some perceive that physicians and intensivists make such decisions differently, and certain specialties do consider life-sustaining treatment more readily than others. 7 Physicians behave variably in withholding treatment for different conditions with similarly poor prognosis -ventilatory support is offered more often for end-stage COPD than for cancer. 7 Outcome predictors in patients requiring invasive ventilation should influence rational practice. Studies show variable prognostic factors 2-6 making it difficult to identify outcome predictors. The recurring independent variables found in more than one study to predict poor prognosis are low serum albumin, 2,4,6 significant comorbidities and high APACHE 11 scores. 3,5,6 (The Acute Physiology and Chronic Health Evaluation (APACHE) score is an index based on physiological variables in critically ill patients that correlates with survival.)This study investigates the perceived and real differences in opinion between intensivists, respiratory and general physicians, the magnitude of variance between individual clinicians, and the comorbidities that most influence decision-making.
MethodA questionnaire was circulated by post to 600 consultants (200 respiratory physicians, 200 general physicians and 200 intensivists) selected randoml...