Accuracy of the Menopause Rating Scale and the Menopause Quality of Life Questionnaire to discriminate menopausal women with anxiety and depression

Abstract

Objective: The aim of the study was to evaluate the accuracy of the Menopause Rating Scale (MRS) and the Menopause Quality of Life Questionnaire (MENQOL) to discriminate women suffering from anxiety (AD) and depression disorder (DD). Methods: A cohort of 416 women aged 45 to 65 years (51.7 ± 3.8) completed the MRS, MENQOL and Hospital Anxiety and Depression Scale, plotting receiver operator curves to assess the diagnostic accuracy of the MRS and MENQOL items related to anxiety and depression. Results: Both the MRS6 (area under the ROC curve [AUC] 0.773, 95% confidence interval [CI] 0.721-0.824) and MENQOL5 (AUC: 0.772, 95% CI 0.723-0.822) proved to be accurate tools to identify individuals with anxiety or with a likelihood to develop AD. Likewise, the items MRS4 (AUC: 0.771, 95% CI 0.625-0.797) and MENQOL8 (AUC: 0.744, 95% CI 0.668-0.821) appeared to be suitable to discriminate individuals with DD. Two cut-off points were established for each item in the different scales to optimize their capacity to detect and discriminate problems of anxiety and depression. Lower cut-off values (MRS ≥ 1; MENQOL ≥ 2) were established to detect AD and DD, the sensitivity of which varied between 76.0% and 84.6%% and a negative predictive value varying between 86.7% and 95.3%. A more specific cut-off was established for the discrimination of AD and DD (MRS ≥ 2; MENQOL ≥ 7), with a specificity ranging from 86.2% to 99.4% and a positive predictive value varying between 68.6% and 92.6%. Conclusions: The MRS and MENQOL display moderate accuracy in discriminating menopausal women with symptoms of anxiety and depression. The intensity of the symptoms appears to be related to the probability of detecting a probable or definitive disorder.

Association of hormone therapy and changes of objective sleep quality in women of late menopausal transition with sleep disorder: a preliminary study

“…The mean total score of different self-report questionnaires was 14.7 ± 3.0 for ISI, 7.2 ± 1.7 for ESS, 10.0 ± 2.1 for PSQI, and 29.0 ± 5.2 for MRS. These scores corresponded to the score indicating sleep disturbance on each scale 9,11,12 …”

Psychometric properties and validity of the Menopause Rating Scale in postmenopausal Portuguese women

“…Anxiety and depression are highly prevalent in the climacteric period 39 . The association between mood alterations and other menopausal symptoms has been amply demonstrated, with strong associations with vasomotor or urogenital symptoms 40,41 …”

“…39 The association between mood alterations and other menopausal symptoms has been amply demonstrated, with strong associations with vasomotor or urogenital symptoms. 40,41 The present study analyzed the convergent validity of the Portuguese version of MRS with the severity of anxiety and depression symptoms as assessed by the HADS questionnaire. The total score of the Portuguese MRS was highly correlated to the anxiety and depression scores of HADS, whereas its 3 domains displayed moderate-to-strong associations except for factor 1 (items 1 and 2) and HADS-depression scores, which were close to reaching a moderate value (r = 0.28).…”

Using Digital Health Technologies to Manage the Psychosocial Symptoms of Menopause in the Workplace: A Narrative Literature Review

“…The higher risk of developing anxiety and depression during menopause crosses cultural boundaries, with research focussed on the correlation between and the effects of menopause and depression evident in China (Tang et al, 2019); India (Majumdar & Dasgupta, 2016); Poland (Kopciuch et al, 2017), Singapore (Ganasarajah et al, 2019), South Korea (Kim & Park, 2018) and Spain (Martin et al, 2019). Similarly, a US study highlights the prevalence of anxiety and depression in peri-and post-menopausal women who have no previous history of depressive or anxiety disorders (Hart, 2019).…”