Accuracy of verbal fluency tests in the discrimination of mild cognitive impairment and probable Alzheimer’s disease in older Spanish monolingual individuals

García-Herranz, Sara; Díaz-Mardomingo, Carmen; Venero, César; Peraita, Herminia

doi:10.1080/13825585.2019.1698710

Cited by 24 publications

(22 citation statements)

References 67 publications

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“…Moreover, we showed that switching and categories verbal fluency are the executive function components that better predict MCI to dementia conversion in the ACS a year later ( Table 10). These findings are consistent with those from other authors [50][51][52][53][54][55][56][57] who supported that category generation should be included in cognitive composites to predict cognitive decline. However, a failure in category verbal fluency may be indicative of language impairment [55].…”

Section: Discussionsupporting

confidence: 93%

Role of Executive Functions in the Conversion from Mild Cognitive Impairment to Dementia

Junquera

García-Zamora

Olazarán

et al. 2020

JAD

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Background: Recent research pointed to executive dysfunction as a potential early predictor of the progression of mild cognitive impairment (MCI) to dementia in Alzheimer’s clinical syndrome (ACS). Such cognitive impairments account for functional impairments in instrumental activities of daily living (IADL). Objective: The present study analyzes the contributions of executive functions to predict MCI–dementia progression in ACS. Methods: We assessed 145 participants, 51 cognitively unimpaired and 94 MCI. The latter were divided using the traditional, memory-based MCI classification (single domain amnestic, multidomain amnestic, and non-amnestic). Eight tests assessing executive functions were administered at baseline and at 1-year follow-up, together with cognitive screening tools and IADL measures. MCI patients were reclassified based on the outcomes from a K-mean cluster analysis which identified three groups. A simple lineal regression model was used to examine whether the classification based on executive functioning could more accurately predict progression to dementia a year later. Results: Clusters based on executive function deficits explained a significant proportion of the variance linked to MCI–dementia conversion, even after controlling for the severity of MCI at baseline (F(1, 68) = 116.25, p = 0.000, R2 = 0.63). Classical memory-based MCI classification failed to predict such a conversion (F(1, 68) = 5.09, p = 0.955, R2 = 0.07). Switching, categories generation, and planning were the executive functions that best distinguished between MCI converters and stable. Conclusion: MCI with a dysexecutive phenotype significantly predicts conversion to dementia in ACS a year later. Switching abilities and verbal fluency (categories) must be evaluated in MCI patients to assess risk of future dementia.

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Section: Discussionsupporting

confidence: 93%

Role of Executive Functions in the Conversion from Mild Cognitive Impairment to Dementia

Junquera

García-Zamora

Olazarán

et al. 2020

JAD

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“…We selected 457 healthy, Caucasian, Spanish, monolingual (Spanish-speaking) older adults who were already enrolled on a larger, ongoing longitudinal research study to determine the prevalence and progression of MCI in the Autonomous Community of Madrid (Spain; García-Herranz et al, 2016, 2020). The participants were selected according to the following criteria: (a) they were between 60 and 90 years old; (b) they were living independently; (c) they were monolingual Spanish speaking; and (d) scored ≥25 on the Mini-Mental State Examination (MMSE—Spanish version Mini-Examen Cognoscitivo; MEC-35; Lobo et al, 1979).…”

Section: Methodsmentioning

confidence: 99%

Normative data for the Spanish version of the California Verbal Learning Test (TAVEC) from older adults.

García-Herranz

Díaz‐Mardomingo

Suárez-Falcón

et al. 2022

Psychological Assessment

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The aim of this study was to establish normative data for the Spanish version of the California Verbal Learning Test, the Test de Aprendizaje Verbal Espa ña-Complutense (TAVEC). Through different subtests, the TAVEC allows verbal learning and episodic memory to be evaluated, an assessment that was carried out on a sample of 382 cognitive healthy Spanish individuals aged 60-90 years old. Unlike the participant's educational level, their age and sex significantly influenced performance in the TAVEC. We provide tables that allow the scaled scores obtained with this test to be adjusted for age and other tables with the relevant adjustments for sex. The normative data obtained in this study will help more precisely interpret the performance of older Spanish adults in the TAVEC, enhancing the utility of this neuropsychological test to evaluate verbal learning and episodic memory in clinical settings and in relation to healthy aging. Public Significance StatementThe present study provides updated normative data for the Spanish version of the California Verbal Learning Test, the Test de Aprendizaje Verbal España-Complutense (TAVEC) in Spanish older adults. The norms produced here are age and sex adjusted, enhancing the utility of this neuropsychological test to evaluate verbal learning and episodic memory in both clinical and research contexts.

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“…MMSE scores were recoded into a dichotomous variable (cognitive impairment) according to education-based cutoffs widely accepted and used in China [ 25 ] (< 18 for participants with no formal education, < 21 for participants with 1–6 years of education, and < 25 for participants with more than 6 years of education). Verbal fluency scores were coded as dichotomous using a cutoff score of < 16 [ 26 ]. Covariates were the same as variables included in the linear regression.…”

Section: Methodsmentioning

confidence: 99%

Urine D-ribose levels correlate with cognitive function in community-dwelling older adults

Zhu

Wei

et al. 2022

BMC Geriatr

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Background D-ribose is involved in the pathogenesis of Alzheimer’s Disease. The study aimed to determine the association between D-ribose and cognitive function in a sample of community-dwelling older adults. Methods A cross-sectional study was conducted in Chaoyang District, Beijing in 2019–2020. Eligible participants were community-based older adults aged 60 years and above. D-ribose was analyzed from the morning urine. Cognitive function, subjective cognitive decline, and depressive symptoms were measured by a battery of neuropsychological tests. Linear regressions were performed to determine the relationship between the urine D-ribose levels and cognitive performance. Results A sample of 1725 participants (67.1% female) aged 60 to 85 years (69.40 ± 5.87 years, mean ± SD) was enrolled in the analysis. The urine D-ribose concentrations ranged from 1.53 to 208.89 μmol/L (median 38.10 μmol/L; interquartile range 22.52—64.96 μmol/L). Higher levels of D-ribose were associated with worse performance on Mini-Mental State Examination and verbal fluency when age, gender, education, depressive symptoms, and cardiovascular risk factors were included as covariates. Conclusions The urine D-ribose was negatively correlated with cognitive function in community-dwelling older adults. The findings suggest that the dysmetabolism of D-ribose may play a role at the early stage of cognitive impairment.

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Accuracy of verbal fluency tests in the discrimination of mild cognitive impairment and probable Alzheimer’s disease in older Spanish monolingual individuals

Cited by 24 publications

References 67 publications

Role of Executive Functions in the Conversion from Mild Cognitive Impairment to Dementia

Role of Executive Functions in the Conversion from Mild Cognitive Impairment to Dementia

Normative data for the Spanish version of the California Verbal Learning Test (TAVEC) from older adults.

Urine D-ribose levels correlate with cognitive function in community-dwelling older adults

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