Accurate prediction of fulminant hepatic failure in severe acute viral hepatitis: multicenter study

Yoshiba, Makoto; Sekiyama, Kazuhiko; Inoue, Kazuaki; Yamada, Masaya; Kako, Makoto; Nagai, Kozo; Takatori, Masao; Iwabuchi, Shogo; Sumino, Yasukiyo; Tanaka, Katsuaki; Hakozaki, Yukiya; Hasegawa, Kiyoshi; Shibuya, Akitaka

doi:10.1007/s005350200154

Cited by 24 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One possibility is that the prognosis of non-A non-B non-C FH is the poorest. 28,29 In this study, of 15 non-A non-B non-C FH patients, 11 (73%) died or underwent Fig. 4.…”

Section: Discussionmentioning

confidence: 96%

Influence of TNF gene polymorphism in patients with acute and fulminant hepatitis

et al. 2004

Self Cite

View full text Add to dashboard Cite

show abstract

“…One possibility is that the prognosis of non-A non-B non-C FH is the poorest. 28,29 In this study, of 15 non-A non-B non-C FH patients, 11 (73%) died or underwent Fig. 4.…”

Section: Discussionmentioning

confidence: 96%

Influence of TNF gene polymorphism in patients with acute and fulminant hepatitis

et al. 2004

Self Cite

View full text Add to dashboard Cite

show abstract

“…In clinical practice, serum ChE activity is widely used as an indicator for the diagnosis and evaluation of treatment effectiveness for organophosphate poisoning (Rehiman et al, 2008). It is also used for the assessment of liver function in patients with various chronic liver diseases (Yoshiba et al, 2002;Kaibori et al, 2008). Serum ChE activity decreases to variable degrees in patients who have suffered severe trauma, but there have been few reports on the dynamic changes occurring in serum ChE activity after injury and/or the clinical significance of these changes.…”

Section: Discussionmentioning

confidence: 99%

“…Serum cholinesterase (ChE), like APPs, is synthesized in the liver and secreted into the blood. ChE activity is lower than the normal in patients with organophosphate poisoning (Rehiman et al, 2008), chronic liver disease (Yoshiba et al, 2002), burns (Kamolz et al, 2002a;2002b), cancer (Chougule et al, 2008), or serious infections (Kassab and Vijayakumar, 1995). The reduction in ChE activity is closely correlated with the severity of the condition and the prognosis.…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes of serum cholinesterase activity after severe trauma

Qian

et al. 2014

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: The aim of the present study was to examine dynamic changes in serum cholinesterase (ChE) activity during early-stage severe trauma and the clinical significance of these changes. Methods: This prospective, observational study included 81 patients with severe trauma who were treated between October 2011 and April 2013 in the emergency intensive care unit (EICU) of a university-affiliated, tertiary-care, grade A general hospital in China. Serum ChE activity was measured on Days 1, 3, and 7 post-injury. The correlation of dynamic changes in serum ChE activity with trauma severity and prognosis was assessed. Correlations between changes in serum ChE activity after injury and albumin (ALB), prealbumin (PAB), transferrin (TRF), and C-reactive protein (CRP) levels were also analyzed. Results: Serum ChE activity in trauma patients was 42.3%-50.2% lower on Days 1, 3, and 7 compared with the control (P<0.001 for all time points), and it continued to decrease after Day 7 in both the survival and death subgroups. In the subgroup with an injury severity score (ISS) of ≤25, serum ChE activity initially decreased, but eventually increased. However, activity decreased continuously in the ISS>25 subgroup. ChE activity was significantly lower in both the death and the ISS>25 subgroups than in the survival and ISS≤25 subgroups on Days 1, 3, and 7 after injury. Activity was negatively correlated with ISS and acute physiology and chronic health evaluation III (APACHE III) at all time points. When comparing the receiver operating characteristic (ROC) curves for predicting prognosis, the area under the curve (AUC) in the plot of serum ChE was similar to the AUCs in plots of ISS and APACHE III, but significantly smaller than the AUC in the plot of the trauma and injury severity score (TRISS). Serum ChE activity was positively correlated with ALB, PAB, and TRF at all time points post-injury. Activity was not significantly correlated with CRP on Day 1, but was significantly and negatively correlated with CRP on Days 3 and 7. Conclusions: There is a significant decrease in serum ChE activity after severe trauma. Serum ChE may be regarded as a negative acute phase protein (APP) and the dynamic changes in serum ChE may be useful as an auxiliary indicator for evaluating trauma severity and predicting prognosis.

show abstract

“…We could not identify the etiology of her condition using blood test results and her clinical course. Her fulminant predictive rates according to the Ministry of Health, Labor and Welfare in Japan and Yoshiba et al . were 29.5% and 93.4% on admission, respectively.…”

Section: Case Reportmentioning

confidence: 99%

Pregnant woman with non‐comatose autoimmune acute liver failure in the second trimester rescued using medical therapy: A case report

Sato

Tomita

Yasue

et al. 2014

Hepatology Research

View full text Add to dashboard Cite

We present the case of a 25-year-old woman at 16 weeks of gestation who presented with non-comatose autoimmune acute liver failure and was at high risk of developing fulminant hepatitis. Predictive formulas indicated a high probability of developing fulminant hepatitis. Unenhanced computed tomography showed marked hepatic atrophy and broadly heterogeneous hypoattenuating areas. The course of her illness was subacute, and the etiology of liver injury was unclear. Considering all of the above, we predicted a poor prognosis. Plasma exchange (PE) and continuous hemodiafiltration (CHDF) therapy were initiated just after admission. A few days after admission, a high titer (×80) of antinuclear antibody was noted. Because autoimmune hepatitis (AIH) was considered a cause of liver failure, treatment with moderate prednisolone (30 mg/day) doses was administrated, with careful consideration of her pregnancy. Thereafter, her laboratory findings and clinical course gradually improved without the need for liver transplantation. A liver biopsy at 18 days after admission indicated a diagnosis of AIH. She continued the pregnancy and delivered a healthy baby without any complications. Eventually, prednisolone doses were decreased to 10 mg, after which her liver function worsened. The second liver biopsy also indicated a diagnosis of AIH. Accordingly, low-dose prednisolone and azathioprine doses (50 mg/day) were administrated to recover her liver function, after which her liver function regained normalcy. This case illustrates that a pregnant woman with non-comatose autoimmune acute liver failure in the first or second trimester of pregnancy and her fetus can be rescued by PE/CHDF therapy and safe moderate doses of prednisolone.

show abstract

Accurate prediction of fulminant hepatic failure in severe acute viral hepatitis: multicenter study

Abstract: The present study indicated that fulminant hepatic failure can be predicted, by a simple discrimination equation, at the stage of severe acute hepatitis.

Cited by 24 publications

References 21 publications

Influence of TNF gene polymorphism in patients with acute and fulminant hepatitis

Influence of TNF gene polymorphism in patients with acute and fulminant hepatitis

Dynamic changes of serum cholinesterase activity after severe trauma

Pregnant woman with non‐comatose autoimmune acute liver failure in the second trimester rescued using medical therapy: A case report

Contact Info

Product

Resources

About