Aiming at the problem that the existing differential confocal measurement (DCM) method lacks the ability to decouple the differential signals from over-range the depth data, which in turn leads to measurement errors, this study proposes a differential confocal effective measurement region extraction method based on dual measurement (D-DCM). The first measurement is a double blur depth measurement, which is a coarse measurement, and the initial acquisition of the depth map is realized by applying a known Gaussian kernel blurring to the focal plane image and calculating the edge gradient ratios between the original image and the blurred image. This depth map is used to determine whether the depth of the measured sample in the field of view is within the differential confocal range and to segment it. The second measurement is a DCM, which is a fine measurement. The effective measurement area of the segmented image is second measured with high precision depth measurement. It is shown by single and multiple step heights experiments that the proposed D-DCM method can effectively solve the problem of decoupling the differential signal from the axial depth in differential confocal.