Accurate Targeting and Controllable Release of Hybrid Liposome Containing a Stretchable Copolymer

Abstract

Developing an intelligent drug delivery/release system, which can transport drugs to the target tissues precisely and release drugs timely, is an important challenge in chemotherapy. A multistage sensitive drug delivery system is designed by inserting a folate (FA) modified lipid and a pH/temperature dual‐sensitive amphiphilic copolymer into a liposome bilayer. The stretchable copolymer plays a role in protection on FA ligand for more accurate targeting. Then, the stretch ability of the copolymer in the liposome bilayer is verified by using the Langmuir–Blodgett film technique. The interaction between the 1,2‐dipalmitoyl‐sn‐glycerol‐3‐phosphocholine (DPPC) monolayer and hybrid liposomes is found to increase, indicating the FA ligand is exposed due to the copolymer shrinking with increasing temperature. Fluorescence polarization measurements demonstrate that the insertion of the copolymer improves the stability of the liposome and offers pH‐controllability for drug release. As a result, the drug leakage of the hybrid liposome is restrained significantly at pH 7.4, while at an acidic pH, the drug release is accelerated. The designed pH/temperature dual‐sensitive copolymer is expected to provide more precise targeting and environmentally controlled drug release to drug delivery systems based on liposomes.

Multifunctional zinc phthalocyanine‐phenolic resin (ZnPc‐PFR)@MSN nanocomposite based fluorescent imaging, photothermal therapy, and pH‐sensitive drug release

“…Recently, a series of nanoparticles has caused great attention to drug delivery, including liposomes, 1–3 micelles, 4–7 viruses, 8 microcapsules, 9–11 carbon nanotube, 12–15 mesoporous MSNs, 16–19 and gold nanoparticles (Au NPs) 20–23 . MSNs often show adjustable pore size distribution, regular pore structure, high surface‐area‐to‐volume ratio, low cytotoxicity, and good thermal stability characteristics 24–27 .…”

Development of Highly Sensitive Molecular Blocks at Cancer Microenvironment for Rapid Cancer Cell Death

“…Nanotechnology has been actively investigated to target malignant tissues due to their easy functionalization and their nanosize allowing a facile access to biological compartments . Various drug delivery systems (DDS) have been experimented for improving delivery efficiency into the tumor site, such as micelles, , liposomes, , or dendrimers. , These constructions allow the modulation of the physicochemical parameters of a drug and enhance their bioavailability in tissue. Among them, polymeric nanoparticles have attracted increasing attention because of their bioavailability, biodegradability, and long-time retention as compared to other formulations .…”

Facile synthesis of novel fluorescent phenol formaldehyde resin nanospheres for drug release

“…[8][9][10] Almost all anti-tumor drugs can damage normal cells while killing cancer cells, especially for added value, among which vigorous bone marrow hematopoietic cells are more seriously damaged. [11][12][13] To solve these drawbacks while exploring successful deliveries of anti-cancer drugs for drug deliveries as well as controlled drug release specifically for tumorous regions, various types of nanocarrier systems have been attracting wide attention over the last decade, which include organic materials, such as, liposomes, 14,15 micelles, 16,17 viruses, 18,19 and microcapsules, 20,21 as well as inorganic nanoparticles, such as, carbon nanotubes, 22 mesoporous silica nanospheres (MSNs) 23,24 and gold nanoparticles (Au NPs). 25,26 Recently, porous nanomaterials (microporous zeolites and mesoporous silica) in biomedical applications attract people's great attention.…”