The proposed nomogram resulted in more-accurate prognostic prediction for patients with ICC after partial hepatectomy.

SUMMARYFibroblast heterogeneity has long been recognized in mouse and human lungs, homeostasis, and disease states. However, there is no common consensus on fibroblast subtypes, lineages, biological properties, signaling, and plasticity, which severely hampers our understanding of the mechanisms of fibrosis. To comprehensively classify fibro-blast populations in the lung using an unbiased approach, single-cell RNA sequencing was performed with mesenchymal preparations from either uninjured or bleomycin-treated mouse lungs. Single-cell transcriptome analyses classified and defined six mesenchymal cell types in normal lung and seven in fibrotic lung. Furthermore, delineation of their differentiation trajectory was achieved by a machine learning method. This collection of single-cell transcriptomes and the distinct classification of fibroblast subsets provide a new resource for understanding the fibroblast landscape and the roles of fibroblasts in fibrotic diseases.

Accurate prediction of others' trajectories is essential for autonomous driving. Trajectory prediction is challenging because it requires reasoning about agents' past movements, social interactions among varying numbers and kinds of agents, constraints from the scene context, and the stochasticity of human behavior. Our approach models these interactions and constraints jointly within a novel Multi-Agent Tensor Fusion (MATF) network. Specifically, the model encodes multiple agents' past trajectories and the scene context into a Multi-Agent Tensor, then applies convolutional fusion to capture multiagent interactions while retaining the spatial structure of agents and the scene context. The model decodes recurrently to multiple agents' future trajectories, using adversarial loss to learn stochastic predictions. Experiments on both highway driving and pedestrian crowd datasets show that the model achieves state-ofthe-art prediction accuracy.