Prognostic Nomogram for Intrahepatic Cholangiocarcinoma After Partial Hepatectomy

Wang, Yizhou; Li, Jun; Xia, Yong; Gong, Rui; Wang, Kui; Yan, Zhenlin; Wan, Xia; Liu, Guanghua; Wu, Dong; Shi, Liangrong; Lau, W. Y.; Wu, Mengchao; Shen, Feng

doi:10.1200/jco.2012.41.5984

Cited by 962 publications

(973 citation statements)

References 33 publications

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“…Analysis by the ICC nomogram followed what we reported previously [7] (supplemental online Table 1). Statistical performance of the nomogram was assessed by discrimination and calibration.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, we reported on a prognostic nomogram (the ICC nomogram) that was specifically established for patients with ICC and that had good long-term survival prediction after partial hepatectomy [7]. Unlike other contemporary staging systems, this nomogram can provide a prognostic prediction at an individual level.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, increasing incidence of ICC has been reported worldwide [4]. Liver resection is still the primary and the most effective treatment for ICC [4][5][6][7][8]; however, ICC is known to have aggressive metastatic behavior, and the surgical prognosis is still poor [5]. The reported 5-year postsurgical survival rates ranged from 20% to 35% [6][7][8].There is still no well-established adjuvant protocol for ICC after R0 liver resection [4].…”

Section: Introductionmentioning

confidence: 99%

“…Liver resection is still the primary and the most effective treatment for ICC [4][5][6][7][8]; however, ICC is known to have aggressive metastatic behavior, and the surgical prognosis is still poor [5]. The reported 5-year postsurgical survival rates ranged from 20% to 35% [6][7][8].There is still no well-established adjuvant protocol for ICC after R0 liver resection [4]. Previous studies showed transarterial chemoembolization (TACE) to be beneficial for patients with advanced and unresectable ICCs [9,10]; however, to the best of our knowledge, only three studies reported the use of adjuvant TACE in ICC patients after curative resection.…”

Section: Introductionmentioning

confidence: 99%

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Adjuvant Transarterial Chemoembolization Following Liver Resection for Intrahepatic Cholangiocarcinoma Based on Survival Risk Stratification

Wang

Lei

et al. 2015

The Oncologist

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Background. The effectiveness of adjuvant transarterial chemoembolization (TACE) for intrahepatic cholangiocarcinoma (ICC) after hepatectomy remains unclear. This study was performed to identify ICC patients who would benefit from adjuvant TACE. Patients and Methods. The study included 553 patients who underwent hepatectomy for ICC between January 2008 and February 2011 at the Eastern Hepatobiliary Surgery Hospital and who were treated with or without TACE (122 with TACE and 431 without TACE). Survival risk stratification was performed using the established prognostic nomogram (ICC nomogram). The predictive performance was evaluated by concordance index and calibration. The tumor recurrence and overall survival (OS) rates were analyzed by the Kaplan-Meier method before and after propensity score matching (PSM).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adjuvant Transarterial Chemoembolization Following Liver Resection for Intrahepatic Cholangiocarcinoma Based on Survival Risk Stratification

Wang

Lei

et al. 2015

The Oncologist

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“…The lesion presented many poor prognostic factors such as its size, presence of macrovascular invasion and multiple tumoral satellite nodules. Given these observations, the prognosis was expected to be poor and according to the Wang et al nomogram [17], this type of lesion is associated with a dismal (i.e. <10%) 3-year survival rate.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Therapy including Yttrium-90 Radioembolization as a Bridging Therapy to Liver Transplantation for a Huge and Locally Advanced Intrahepatic Cholangiocarcinoma

Rayar

Sandri

Houssel‐Debry

et al. 2016

JGLD

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Treatment of intrahepatic cholangiocarcinoma remains a major challenge. For an unresectable lesion without extrahepatic spread, liver transplantation could be a potential solution but it is still associated with poor oncologic results owing to the absence of effective neoadjuvant treatment. We report the case of a young man with locally advanced intrahepatic cholangiocarcinoma presenting with multiple intrahepatic metastases and vascular structure involvement. The lesion was significantly downstaged by a multimodal therapy including intra-arterial Yttrium-90 radioembolization, systemic chemotherapy and external radiotherapy, allowing liver transplantation. Three years after the procedure, oncologic outcome is excellent with no sign of recurrence.Multimodal therapy including Yttrium-90 radioembolization could be relevant as neoadjuvant treatment before liver transplantation for unresectable intrahepatic cholangiocarcinoma. Abbrevations: CA 19-9: carbohydrate antigen 19-9; FDG-PET: fluorodeoxyglucose positron emission tomography; HCC: hepatocellular carcinoma; ICC: intrahepatic cholangiocarcinoma; LT: liver transplantation; MRI: magnetic resonance imaging; PHC: perihilar cholangiocarcinoma; Ytt-90: Yttrium-90.

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Assessment of Clinicopathological Characteristics and Development of an Individualized Prognostic Model for Patients With Hepatoid Adenocarcinoma of the Stomach

Wang

Hong

et al. 2021

JAMA Netw Open

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IMPORTANCEFew studies have examined the clinicopathological characteristics and prognoses of patients with hepatoid adenocarcinoma of the stomach (HAS). OBJECTIVE To explore the clinicopathological characteristics and prognoses of patients with HAS and develop a nomogram to predict overall survival (OS). DESIGN, SETTING, AND PARTICIPANTS This prognostic study involved a retrospective analysis of data from 315 patients who received a diagnosis of primary HAS between April 1, 2004, and December 31, 2019, at 14 centers in China. MAIN OUTCOMES AND MEASURES OS and prognostic factors. Patients were randomly assigned to a derivation cohort (n = 220) and a validation cohort (n = 95). A nomogram was developed based on independent prognostic factors identified through a multivariable Cox mixed-effects model. RESULTS Among 315 patients with HAS (mean [SD] age, 61.9 [10.2] years; 240 men [76.2%]), 137patients had simple HAS (defined as the presence of histologically contained hepatoid differentiation areas only), and 178 patients had mixed HAS (defined as the presence of hepatoid differentiation areas plus common adenocarcinoma areas). Patients with simple HAS had a higher median preoperative α-fetoprotein level than those with mixed HAS (195.9 ng/mL vs 48.9 ng/mL, respectively; P < .001) and a higher rate of preoperative liver metastasis (23 of 137 patients [16.8%] vs 11 of 178 patients [6.2%]; P = .003). The 3-year OS rates of patients with simple vs mixed HAS were comparable (56.0% vs 60.0%; log-rank P = .98). A multivariable Cox analysis of the derivation cohort found that the presence of perineural invasion (hazard ratio [HR], 2.13; 95% CI,

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Prognostic Nomogram for Intrahepatic Cholangiocarcinoma After Partial Hepatectomy

Abstract: The proposed nomogram resulted in more-accurate prognostic prediction for patients with ICC after partial hepatectomy.

Cited by 962 publications

References 33 publications

Adjuvant Transarterial Chemoembolization Following Liver Resection for Intrahepatic Cholangiocarcinoma Based on Survival Risk Stratification

Adjuvant Transarterial Chemoembolization Following Liver Resection for Intrahepatic Cholangiocarcinoma Based on Survival Risk Stratification

Multimodal Therapy including Yttrium-90 Radioembolization as a Bridging Therapy to Liver Transplantation for a Huge and Locally Advanced Intrahepatic Cholangiocarcinoma

Assessment of Clinicopathological Characteristics and Development of an Individualized Prognostic Model for Patients With Hepatoid Adenocarcinoma of the Stomach

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