ACE gene polymorphism and serum ACE activity in Iranians type II diabetic patients with macroalbuminuria

Felehgari, Vahid; Rahimi, Zohreh; Mozafari, Hadi; Vaisi‐Raygani, Asad

doi:10.1007/s11010-010-0587-2

Cited by 31 publications

(26 citation statements)

References 21 publications

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“…It has been demonstrated that T2DM patients with normoor micro-albuminuria carrying I allele had a better response to ACE inhibitor therapy compared to those patients with D allele. While, in T2DM with overt nephropathy and D allele there was a better response to angiotensin II receptor antagonists therapy compared to I allele (5,12,37,38). Similar comparable results were obtained in T1DM (39).…”

Section: Ace I/d Polymorphism and Response To Therapysupporting

confidence: 72%

“…The frequency of ACE alleles varies in different ethnic groups and might contribute to the conflicting results related to the role of ACE (I/D) polymorphism in diabetic nephropathy (5,6).…”

Section: Angiotensin Converting Enzyme (Ace) Gene Polymorphismmentioning

confidence: 99%

“…DN is manifested with microalbuminuria that subsequently can progress to macroalbuminuria (13,14). The ACE is a key component of renin angiotensin system (RAS) that plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II and by inactivating the vasodilator peptides bradykinin and angiotensin (1)(2)(3)(4)(5)(6)(7)15). ACE regulates microcirculation within the kidney through generating angiotensin II and in the presence of ACE D allele, the GFR increases in correlation with ACE plasma levels (1,16).…”

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 99%

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ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

Rahimi¹

2012

J Nephropathol

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Implication for health policy/practice/research/medical education:The presence of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with highest systemic and renal ACE levels, compared with the lowest ACE activity in carriers of II genotype. Most studies confirmed that ACE I/D polymorphism is involved in the susceptibility to overt nephropathy with protective role of ACE II genotype against the disease in both type 1 and 2 diabetes mellitus. In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Results:The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype. Conclusions: In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.Review Article

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Section: Ace I/d Polymorphism and Response To Therapysupporting

confidence: 72%

“…The frequency of ACE alleles varies in different ethnic groups and might contribute to the conflicting results related to the role of ACE (I/D) polymorphism in diabetic nephropathy (5,6).…”

Section: Angiotensin Converting Enzyme (Ace) Gene Polymorphismmentioning

confidence: 99%

Section: Ace I/d Polymorphism: Onset and Progression Of Diabetic Nephmentioning

confidence: 99%

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ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

Rahimi¹

2012

J Nephropathol

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“…Thus, the contribution of ACE gene polymorphism to the heritable part of risk for diabetic nephropathy seems important, and is supported by findings from published meta-analyses [28,62] along with other studies done among Indians [31,63], Japanese [29], French [64], Egyptian [65] and Taiwan [27] diabetic patients. However, our results do not coincide with studies done among Chinese [66], Tunisian [55], French [56], Turkish [34] and Iranian [67] diabetic cases. This discrepancy in polymorphisms association studies may be reconciled by several factors, with ethnic/racial and geographic differences being a potential reason i.e.…”

Section: Discussioncontrasting

confidence: 99%

Genetic Predisposition to Diabetic Nephropathy: Evidence for a Role of ACE (I/D) Gene Polymorphism in Type 2 Diabetic Population from Kutch Region

et al. 2013

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Genetic polymorphism as described with angiotensin-converting enzyme gene has been proposed as a putative mediator of diabetic nephropathy. We substantiate the hypothesis that genetic variants of the ACE have significant impacts on diabetic nephropathy. To assess the possible association between the three ACE polymorphic variants and DN in an ethnically homogeneous type 2 diabetic population from Kutch region. A 287-bp insertion/deletion polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction using a case-control approach conducted with 309 unrelated type 2 diabetic patients of Kutch origin (159 Ahir and 150 Rabari, with [10 years duration of T2DM). Of the patients, 143 had nephropathy {AER[30 mg/day (Ahir, n:73 and Rabari, n:70)} and were considered as cases; all others {n:166 (86 Ahir and 80 Rabari)} were normoalbuminuric (AER\30 mg/day) and were treated as controls. Suitable descriptive statistics was used for different variables. Genotype frequencies in all groups were all in accordance with the Hardy-Weinberg equilibrium. Genotypic distribution was significantly different between cases and controls (Ahir: x 2 :8.87, 2 d.f. p = 0.0118; Rabari: x 2 :11.01, 2 d.f. p = 0.0041). Multivariate logistic regression analysis revealed that DD genotype was a significant and strongest independent predictor of microalbuminuria (Ahir: p = 0.0362, OR = 2.65, 95 % CI 1.89-6.36; Rabari: p = 0.024, OR = 2.81, 95 % CI 1.9-6.65). However, it did not independently change the odds of having macroalbuminuria versus microalbuminuria. Analysis of the association under various genetic models revealed that ACE I/D polymorphic variant contribute to DN susceptibility under recessive mode only. Genetic variation at the ACE locus as D/D variant in intron 16, contribute to an increased risk of nephropathy in T2DM patients but not extent of DN severity, and thus this polymorphism might be considered as genetic risk factors for DN among patients with type 2 diabetes.

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“…Genomic DNA was extracted from EDTA-treated whole blood using the phenol-chloroform method (16). Nanodrop spectrophotometer (Thermo) was used for the analysis of concentration and purity of extracted DNA.…”

Section: Genotype Analysismentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Its Synergism with L/S Polymorphism in the Promoter Region of Serotonin Transporter in Bipolar I Disorder Patients in Western Iran

Rahimi

Gravand

Khazaie

et al. 2016

Iran J Psychiatry Behav Sci

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Background: Brain-derived neurotrophic factor (BDNF) might involve in the pathogenesis of mental disorders. There are inconsistent reports related to the role of BDNF Val66Met in susceptibility to bipolar disorder (BD). Objectives: The aim of the present study was to investigate the role of BDNF Val66Met and its synergism with 5-HTT gene-linked polymorphic region (5-HTTLPR) variants in susceptibility to bipolar I disorder (BP-I) in Western Iran. Materials and Methods:In this case-control study, 153 patients with BP-I and 146 age-and gender-matched healthy individuals were investigated for BDNF and 5-HTTLPR variants using PCR-RFLP method. Results: The frequency of BDNF A (Met) allele in patients (17.7%) was slightly lower than that in controls (19.9%, P = 0.5). The concomitant presence of BDNF G (Val) and 5-HTTLPR S alleles tended to increase the risk of BP-I by 1.41 times (P = 0.064) compared to the combined presence of BDNF G and 5-HTTLPR L alleles. Also, interaction between BDNF G (Val) and 5-HTTLPR S tended to increase the risk of BP-I by 1.28-fold (P = 0.062) compared to the concomitant presence of BDNF A and 5-HTTLPR S alleles. Conclusions: This study, conducted for the first time on Kurdish population in Western Iran, did not indicate any association between BDNF Val66Met with BP-I. However, the interaction between BDNF and 5-HTTLPR variants tended to increase the susceptibility to BP-I.

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ACE gene polymorphism and serum ACE activity in Iranians type II diabetic patients with macroalbuminuria

Cited by 31 publications

References 21 publications

ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy

Genetic Predisposition to Diabetic Nephropathy: Evidence for a Role of ACE (I/D) Gene Polymorphism in Type 2 Diabetic Population from Kutch Region

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Its Synergism with L/S Polymorphism in the Promoter Region of Serotonin Transporter in Bipolar I Disorder Patients in Western Iran

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