ACE insertion/deletion polymorphism is associated with periodontal disease in Korean population

Sw, Kang; Han, Sang-Jae; Lim, Sun Gyo; Cho, Kyu Bong; Ban, Ju Yeon

doi:10.1016/j.archoralbio.2014.12.003

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…Although this variant was primarily investigated in relation to cardiovascular diseases [Yang et al, 2013;Song et al, 2014;Zhao et al, 2014;Ma et al, 2015], cancer [Zhang et al, 2014] and diabetic nephropathy [Yu et al, 2012;Rahimi et al, 2014], some studies have also associated this gene polymorphism with various diseases in the oral cavity. In the Czech population, the D allele was previously found to be marginally risky for chronic periodontitis [Izakovicova Holla et al, 2001] and in the Korean population, the DD genotype has already been associated with chronic periodontitis [Kang et al, 2015]. On the other hand, in the Turkish population, the D allele was described as protective for chronic periodontitis; moreover, no association with generalized aggressive periodontitis was found [Gürkan et al, 2009a, b].…”

Section: Discussionmentioning

confidence: 93%

ACE Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children

Linhartová

Kaštovský²,

Bartošová³

et al. 2016

Caries Res

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Objective: Dental caries is a multifactorial, infectious disease where genetic predisposition plays an important role. Insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) has very recently been associated with caries in Polish children. The aim of this study was to analyze ACE I/D polymorphism in a group of caries-free children versus subjects affected by dental caries in the Czech population. Materials and Methods: In this case-control study, 182 caries-free children (with decayed/missing/filled teeth, DMFT = 0), 561 subjects with dental caries (DMFT ≥1) aged 13-15 years and 220 children aged 2-6 years with early childhood caries (ECC, dmft ≥1) were included. Genotype determination of ACE I/D polymorphism in intron 16 was based on the TaqMan method. Results: Although no significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed, statistically significant differences between the children with DMFT = 0 and the subgroup of 179 patients with high caries experience (DMFT ≥4; p < 0.01 and p < 0.05, respectively) were detected. The comparison of DD versus II+ID genotype frequencies between the patients with DMFT ≥1 or DMFT ≥4 and healthy children also showed significant differences (31.5% or 35.6% vs. 23.6%, p < 0.05 or p < 0.01, respectively). A gender-based analysis identified a significant difference in the DD versus II+ID genotype frequencies only in girls (p < 0.05). In contrast, no significant association of ACE I/D polymorphism with ECC in young children was found (p > 0.05). Conclusions:ACE I/D polymorphism may be associated with caries in permanent but not primary dentition, especially in girls in the Czech population.

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Section: Discussionmentioning

confidence: 93%

ACE Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children

Linhartová

Kaštovský²,

Bartošová³

et al. 2016

Caries Res

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“…For example, several studies Kremeyer et al 2005;Zawicki and Witas 2008) have screened skeletal samples for the presence of an allele (CCR5D32) that confers resistance to HIV in living populations and also might have been beneficial during medieval plague outbreaks. Other studies have explored the genetic basis of specific skeletal pathologies, including rheumatoid arthritis (Korczowska 2014), ankylosing spondylitis (Sparks and Costenbader 2014), periodontal disease (Genco and Borgnakke 2013;Kang et al 2014), osteochondritis dissecans (Bates et al 2014), bone cancers (Kuehl and Bergsagel 2002;Mundy 2002;Prideaux et al 2014), and hundreds of inherited skeletal disorders (Warman et al 2011).…”

Section: Examination Of Frailty and Demographymentioning

confidence: 99%

The Osteological Paradox 20 Years Later: Past Perspectives, Future Directions

2015

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More than 20 years ago, Wood et al. (Curr Anthropol 33:343-370, 1992) published ''The Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,'' in which they challenged bioarchaeologists to consider the effects of heterogeneous frailty and selective mortality on health inferences in past populations. Here, we review the paper's impact on bioarchaeology and paleopathology, focusing on recent advancements in studies of ancient health. We find the paper is often cited but infrequently engaged in a meaningful way. Despite an initial decade of limited progress, numerous researchers are now addressing components of the Paradox in more informed ways. We identify four areas of fruitful research: (1) intrasite, contextual perspectives, (2) subadults, (3) associating stress markers with demographic phenomena, and (4) skeletal lesion-formation processes. Although often seen as a problematic assumption, understanding the sources of heterogeneous frailty within human populations is a worthy research question in and of itself, and one that clearly links past and present health research within a global framework.

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“…In the present study on 418 patients from western Black Sea region of Turkey, however, ACE gene I/D polymorphism and ACE gene alleles were not found to be associated with liver fibrosis severity. The ACE gene DD genotype is thought to be associated with an increased risk of rheumatic heart disease in the Saudi population (Al-Harbi et al, 2015), with nitric oxide metabolite levels and systolic blood pressure in clinically healthy Mexican men (no effect in women) (Avila-Vanzzini et al, 2015), with high altitude pulmonary edema in an Indian population (Bhagi et al, 2015), with sepsis susceptibility in Chinese patients (Yang and Zhou, 2015), with periodontal disease susceptibility in a Korean population (Kang et al, 2015), and with cancer risk in Caucasians (Zhang et al, 2014). It has been suggested that ACE gene I/D polymorphism is a genetic risk factor for Alzheimer's disease in a Chinese population (Yuan et al, 2015), while there is reportedly no association between ACE I/D gene polymorphism and a number of conditions and associated risks including type 1 diabetic nephropathy (T1DN) susceptibility and the risk of patients with type 1 diabetes mellitus developing T1DN in a Caucasian population , chronic obstructive pulmonary disease (Ayada et al, 2014) and retinal vein occlusion (Kutlutürk et al, 2014) in a Turkish population, as well as type 2 diabetic nephropathy (T2DN) susceptibility and the risk of patients with type 2 diabetes mellitus developing T2DN in Caucasian populations .…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

Nk¹,

Su²,

Ac³

et al. 2015

Genet. Mol. Res.

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ACE insertion/deletion polymorphism is associated with periodontal disease in Korean population

Cited by 7 publications

References 34 publications

<b><i>ACE</i></b> Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children

<b><i>ACE</i></b> Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children

The Osteological Paradox 20 Years Later: Past Perspectives, Future Directions

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

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