Aceclofenac vs paracetamol in the management of symptomatic osteoarthritis of the knee: a double-blind 6-week randomized controlled trial1,2

Abstract

At 6 weeks, patients with symptomatic OA of the knee showed a greater improvement in pain and functional capacity with aceclofenac than paracetamol with no difference in tolerability.

Efficacy and safety of aceclofenac in osteoarthritis: A meta-analysis of randomized controlled trials

“…As shown in Figure 2, both sequence generation and allocation concealment were adequate in four trials (41)(42)(43)48 (41)(42)(43)(46)(47)(48). No study was deemed adequate with respect to the blinding of outcome assessment.…”

“…Table 1 shows the general characteristics of all nine included trials, including study design, total number of randomized participants, gender distribution, trial duration, dose, and number of randomized patients for aceclofenac and control drugs (40)(41)(42)(43)(44)(45)(46)(47)(48). Control drugs were diclofenac in five trials (41-44, 45), piroxicam in two (46, 47), and acetaminophen (48) and naproxen (40) in one trial each. All included trials except one were double blind (44).…”

Effectiveness of diclofenac versus paracetamol in knee osteoarthritis: a randomised controlled trial in primary care

“…And those who had used medication prior to the study (diclofenac group: n = 11; paracetamol group: n = 17) did not use it in the same dosage as prescribed in the trial. Other studies often use a wash-out period, 11,14 or even need a flare of symptoms after a wash-out period 25 prior to randomisation. Use of a flare design might result in higher treatment effects, 26 and this might reduce generalisability of the results in daily practice.…”

“…12 In addition, previous studies mostly included patients recruited in a secondary care setting. 12,14,15 Therefore, the aim of this study was to assess the effectiveness of diclofenac compared with paracetamol over a period of 2, 4, and 12 weeks in patients with knee OA in general practice.…”

Aceclofenac–tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone

“…In a previous double-blind study [1], 227 patients with acute LBP received either aceclofenac (2 9 100 mg daily) or diclofenac resinate (2 9 75 mg daily) for 10 days. There was significant difference in favour of aceclofenac for all subjective ratings of pain [21].…”