2022
DOI: 10.1016/j.bioactmat.2022.03.014
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Acellular nerve xenografts based on supercritical extraction technology for repairing long-distance sciatic nerve defects in rats

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Cited by 12 publications
(10 citation statements)
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“…It is hypothesized that ScCO2 might induce hypoxia, which has been validated by histological and morphological analyses after successful decellurization of bovine optic nerves using ScCO2 ( Topuz et al, 2020 ). Wei et al developed a porcine acellular nerve xenograft based on supercritical extraction technology and validated it in a 15-mm rat sciatic nerve model ( Wei et al, 2022 ). A porous nerve basement membrane with a well-preserved 3D structure was observed.…”
Section: Different Approaches Of Physical Processingmentioning
confidence: 99%
“…It is hypothesized that ScCO2 might induce hypoxia, which has been validated by histological and morphological analyses after successful decellurization of bovine optic nerves using ScCO2 ( Topuz et al, 2020 ). Wei et al developed a porcine acellular nerve xenograft based on supercritical extraction technology and validated it in a 15-mm rat sciatic nerve model ( Wei et al, 2022 ). A porous nerve basement membrane with a well-preserved 3D structure was observed.…”
Section: Different Approaches Of Physical Processingmentioning
confidence: 99%
“…The CatWalk footprint machine (XT 10.6, Noldus, Netherlands) was used to assess the locomotion of the rats following surgery 54 . Prior to testing, the rats were trained to become familiar with the footprint recording platform.…”
Section: Assessment Of Functional Recoverymentioning
confidence: 99%
“…11 The success of nerve repair relies on creating an optimal regenerative microenvironment. 12 Within the nerve conduit, an ideal intracavitary microenvironment should encompass crucial factors for nerve regeneration, including immune response modulation, angiogenesis promotion, and signaling molecule regulation. 12,13 By providing these components, the artificial nerve conduit aims to facilitate nerve regeneration and functional recovery.…”
Section: Introductionmentioning
confidence: 99%
“…To overcome these limitations, researchers have developed artificial nerve conduits that hold the potential to replace autologous nerve transplantation as the preferred treatment standard in the future 11 . The success of nerve repair relies on creating an optimal regenerative microenvironment 12 . Within the nerve conduit, an ideal intracavitary microenvironment should encompass crucial factors for nerve regeneration, including immune response modulation, angiogenesis promotion, and signaling molecule regulation 12,13 .…”
Section: Introductionmentioning
confidence: 99%